134-46-3
Chemical Structure
FdUMP triethylammonium
Synonym(s): 2’-Deoxy-5-Fluorouridine 5’-phosphate triethylammonium
- CAS No.: 134-46-3
- Formula:C21H42FN4O8P
- Molecular Weight:528.55
IUPAC Name: triethylamine hemi(((2R,3S,5R)-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxytetrahydrofuran-2-yl)methyl phosphate)
InChIKey: GMLOOKPICKIMMC-OJSHLMAWSA-N
SMILES: O[C@H]1C[C@H](N(C(N2)=O)C=C(F)C2=O)O[C@@H]1COP(O)(O)=O.CCN(CC)CC.CCN(CC)CC
Biological Activity: FdUMP triethylammonium is the intracellular active form of 5-fluorouracil (5-FU). 5-FU is converted to FdUMP after being transported into the cell by various enzymes. FdUMP forms a ternary complex with thymidylate synthase and its cofactor 5,10-methylene tetrahydrofolate, inhibiting the activity of thymidylate synthase, which in turn leads to the suppression of DNA synthesis.
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FdUMP triethylammonium | 99.96% | FdUMP triethylammonium is the intracellular active form of 5-fluorouracil (5-FU). 5-FU is converted to FdUMP after being transported into the cell by various enzymes. FdUMP forms a ternary complex with thymidylate synthase and its cofactor 5,10-methylene tetrahydrofolate, inhibiting the activity of thymidylate synthase, which in turn leads to the suppression of DNA synthesis. | ||||||||||||||||||||
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Keywords
