FdUMP triethylammonium
Based on 1 Customer Validation
FdUMP triethylammonium is the intracellular active form of 5-fluorouracil (5-FU). 5-FU is converted to FdUMP after being transported into the cell by various enzymes. FdUMP forms a ternary complex with thymidylate synthase and its cofactor 5,10-methylene tetrahydrofolate, inhibiting the activity of thymidylate synthase, which in turn leads to the suppression of DNA synthesis.
For research use only. We do not sell to patients.
- Purity: 99.96%
- CAS No.: 134-46-3
- Formula: C21H42FN4O8P
- Molecular Weight:528.55
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CCRF-CEM | IC50 |
0.05 μM
Compound: 4, FdUMP, 5-FdUMP
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Cytostatic activity against human CEM cells expressing human ENT1 transporter after 72 hrs by cell counting
Cytostatic activity against human CEM cells expressing human ENT1 transporter after 72 hrs by cell counting
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[PMID: 21892829] |
| CCRF-CEM | IC50 |
1.06 μM
Compound: 4, FdUMP, 5-FdUMP
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Cytostatic activity against human CEM cells expressing human ENT1 transporter after 72 hrs by cell counting in presence of NBMPR
Cytostatic activity against human CEM cells expressing human ENT1 transporter after 72 hrs by cell counting in presence of NBMPR
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[PMID: 21892829] |
| CCRF-CEM | IC50 |
1.74 μM
Compound: 4, FdUMP, 5-FdUMP
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Cytostatic activity against human CEM cells expressing human ENT1 transporter after 72 hrs by cell counting in presence of dipyridamole
Cytostatic activity against human CEM cells expressing human ENT1 transporter after 72 hrs by cell counting in presence of dipyridamole
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[PMID: 21892829] |
| CCRF-CEM | IC50 |
3.6 μM
Compound: 4, FdUMP, 5-FdUMP
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Cytostatic activity against ENT1 transporter-deficient human CEM cells after 72 hrs by cell counting
Cytostatic activity against ENT1 transporter-deficient human CEM cells after 72 hrs by cell counting
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[PMID: 21892829] |
Chemical Information
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CAS No. 134-46-3
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Appearance Solid
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Molecular Weight 528.55
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Formula C21H42FN4O8P
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Color White to off-white
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SMILES
O[C@H]1C[C@H](N(C(N2)=O)C=C(F)C2=O)O[C@@H]1COP(O)(O)=O.CCN(CC)CC.CCN(CC)CC
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Synonyms
2’-Deoxy-5-Fluorouridine 5’-phosphate triethylammonium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 125 mg/mL (236.50 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.8920 mL | 9.4598 mL | 18.9197 mL | 47.2992 mL |
| 5 mM | 0.3784 mL | 1.8920 mL | 3.7839 mL | 9.4598 mL | |
| 10 mM | 0.1892 mL | 0.9460 mL | 1.8920 mL | 4.7299 mL | |
| 15 mM | 0.1261 mL | 0.6307 mL | 1.2613 mL | 3.1533 mL | |
| 20 mM | 0.0946 mL | 0.4730 mL | 0.9460 mL | 2.3650 mL | |
| 25 mM | 0.0757 mL | 0.3784 mL | 0.7568 mL | 1.8920 mL | |
| 30 mM | 0.0631 mL | 0.3153 mL | 0.6307 mL | 1.5766 mL | |
| 40 mM | 0.0473 mL | 0.2365 mL | 0.4730 mL | 1.1825 mL | |
| 50 mM | 0.0378 mL | 0.1892 mL | 0.3784 mL | 0.9460 mL | |
| 60 mM | 0.0315 mL | 0.1577 mL | 0.3153 mL | 0.7883 mL | |
| 80 mM | 0.0236 mL | 0.1182 mL | 0.2365 mL | 0.5912 mL | |
| 100 mM | 0.0189 mL | 0.0946 mL | 0.1892 mL | 0.4730 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
FdUMP triethylammonium Related Classifications
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