2-Oleoylglycerol  (Synonyms: 2-OG)

2-Oleoylglycerol (2-OG) is a lipid found in the diet. It is a GPR119 agonist, with an EC₅₀ value of 2.5 μM in activating hGPR119 in transiently transfected COS-7 cells. 2-Oleoylglycerol enhances the inflammatory response of macrophages and promotes fibrosis by activating the GPR119/TAK1/NF-κB/TGF-β1 signaling pathway. It also stimulates glucagon-like peptide 1 (GLP-1) secretion in vivo. 2-Oleoylglycerol is expected to be used in the research of non-alcoholic steatohepatitis (NASH) ^[1][2][3].

IC50: 2.5 μM (hGPR119) (in COS-7 cells)^[1]

2-Oleoylglycerol (50 μg/mL, 24 hours) activates RAW264.7 cells via the GPR119/TAK1/NF-κB/TGF-β1 signaling pathway^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2-Oleoylglycerol (20 μg/mouse in 0.2 mL PBS, i.v., three times a week for 6 weeks) induces liver fibrosis in a non-alcoholic steatohepatitis (NASH) model through promoting TGF-β1 production in liver MΦs^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

356.55

C₂₁H₄₀O₄

3443-84-3

Liquid

Colorless to light yellow

OCC(CO)OC(CCCCCCC/C=C\CCCCCCCC)=O

Room temperature in continental US; may vary elsewhere.

Solution, -20°C, 2 years

• [1]. Hansen KB, et, al. 2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans. J Clin Endocrinol Metab. 2011 Sep;96(9):E1409-17.  [Content Brief]

  [2]. Ghafouri N, et, al. Inhibition of monoacylglycerol lipase and fatty acid amide hydrolase by analogues of 2-arachidonoylglycerol. Br J Pharmacol. 2004 Nov;143(6):774-84.  [Content Brief]

  [3]. Yang M, et al. Western diet contributes to the pathogenesis of non-alcoholic steatohepatitis in male mice via remodeling gut microbiota and increasing production of 2-oleoylglycerol. Nat Commun. 2023 Jan 16;14(1):228.  [Content Brief]