3340 Results for "

lipid

" in MedChemExpress (MCE) Product Catalog:
Products (3340)

3340 Results for "lipid" in MCE Product Catalog:

1568
Ferrostatin-1
Ferrostatin-1
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1568 Publications Verification
Cat. No.: HY-100579
CAS No.: 347174-05-4
Purity:  99.71%
Synonyms: Fer-1
Target:  

Ferroptosis Fungal

Research Areas:  

Cancer

Ferrostatin-1 (Fer-1), a potent and selective ferroptosis inhibitor, suppresses Erastin-induced ferroptosis in HT-1080 cells (EC50=60 nM). Ferrostatin-1, a synthetic antioxidant, acts via a reductive mechanism to prevent damage to membrane lipids and thereby inhibits cell death. Ferrostatin-1 exhibits antifungal activity .
668
Acetylcysteine
Acetylcysteine
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668 Cited Publications
Cat. No.: HY-B0215
CAS No.: 616-91-1
Synonyms: N-Acetylcysteine; N-Acetyl-L-cysteine; NAC
Category:  

Ketones, Aldehydes, Acids Endogenous metabolite

Target:  

Reactive Oxygen Species (ROS) Endogenous Metabolite Apoptosis Ferroptosis Influenza Virus Disulfidptosis

Acetylcysteine (N-Acetylcysteine) is a mucolytic agent that can cross the blood-brain barrier, which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor. Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases. Acetylcysteine induces cell apoptosis. Acetylcysteine also has anti-influenza virus activities. In addition, Acetylcysteine ​​is the most stable form of cysteine ​​during drug delivery and can be used in disulfidptosis studies .
510
Lipopolysaccharides, from E. coli O55:B5
Lipopolysaccharides, from E. coli O55:B5
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510 Cited Publications
Cat. No.: HY-D1056
Synonyms: LPS, from Escherichia coli (O55:B5)
Category:  

Natural Products Microorganisms Disease Research Fields Inflammation/Immunology

Target:  

Toll-like Receptor (TLR)

Lipopolysaccharides, from E. coli O55:B5 (LPS, from Escherichia coli (O55:B5)) are endotoxins and TLR4 activators extracted from Escherichia coli (E. coli O55:B5) and are classified as S (smooth) type LPS. Lipopolysaccharides, from E. coli O55:B5 possess the typical three-part structure: O-antigen, core oligosaccharide, and lipid A. Lipopolysaccharides, from E. coli O55:B5 activate TLR-4 in immune cells, exhibit high pyrogenicity, and demonstrate dose and serotype specificity. Lipopolysaccharides, from E. coli O55:B5 can be widely used to induce cellular inflammation and establish animal models related to inflammation .
It is recommended to prepare a solution with concentration ≥2 mg/mL. Vortex thoroughly for more than 10 minutes. Due to the adsorption characteristics of LPS, silanized container or low adsorption centrifuge tubes should be used for aliquoting and storage, and mix thoroughly before use.
216
AICAR phosphate
AICAR phosphate
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216 Cited Publications
Cat. No.: HY-13417A
CAS No.: 681006-28-0
Purity:  99.98%
Synonyms: Acadesine phosphate; AICA Riboside phosphate
Category:  

Alkaloids Animals Other Alkaloids Disease Research Fields Cancer

Target:  

AMPK Autophagy YAP Mitophagy Endogenous Metabolite

AICAR phosphate (Acadesine phosphate) is an adenosine analog and a AMPK activator. AICAR phosphate regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR phosphate is also an autophagy, YAP and mitophagy inhibitor .
216
AICAR
AICAR
0 Images
216 Cited Publications
Cat. No.: HY-13417
CAS No.: 2627-69-2
Purity:  99.98%
Synonyms: Acadesine; AICA Riboside
Category:  

Human Gut Microbiota Metabolites Natural Products Endogenous metabolite Disease Research Fields Cancer

Target:  

AMPK Autophagy YAP Mitophagy Endogenous Metabolite

AICAR (Acadesine) is an adenosine analog and a AMPK activator. AICAR is also an autophagy, YAP and mitophagy inhibitor. AICAR regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR inhibits autophagy through a mechanism independent of AMPK activity .
164
D-Lin-MC3-DMA
D-Lin-MC3-DMA
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164 Cited Publications
Cat. No.: HY-112251
CAS No.: 1224606-06-7
Purity:  99.68%
D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.
136
BODIPY 581/591 C11
BODIPY 581/591 C11
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136 Cited Publications
Cat. No.: HY-D1301
CAS No.: 217075-36-0
BODIPY 581/591 C11 is a BODIPY borofluoroprene derivative with good light stability and low fluorescence artifacts. BODIPY 581/591 C11 can be used for study lipid peroxidation and antioxidant properties in living cells, or detect ferroptosis by reaction with hydroxyl radicals. BODIPY 581/591 C11 is emitted at 591 nm (reduced prototype), or redshifted to 510 nm (oxidized type). The excitation wavelengths were 581 nm (reduced prototype) and 500 nm (oxidized type) .
116
Nile Red
Nile Red
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116 Cited Publications
Cat. No.: HY-D0718
CAS No.: 7385-67-3
Synonyms: Nile Blue A oxazone; Phenoxazone 9
Nile red (Nile blue oxazone) is a lipophilic stain. Nile red has environment-sensitive fluorescence. Nile red is intensely fluorescent in a lipid-rich environment while it has minimal fluorescence in aqueous media. Nile red is an excellent vital stain for the detection of intracellular lipid droplets by fluorescence microscopy and flow cytof uorometry. Nile red stains intracellular lipid droplets red. The fluorescence wavelength is 559/635 nm .
107
BODIPY 493/503
BODIPY 493/503
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107 Cited Publications
Cat. No.: HY-W090090
CAS No.: 121207-31-6
Synonyms: Pyrromethene 546
BODIPY493/503 is a BODIPY dye. BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the neutral lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells . Maximum excitation/emission wavelength: 493/503 nm .
102
PX-478
PX-478
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102 Cited Publications
Cat. No.: HY-10231
CAS No.: 685898-44-6
Purity:  ≥98.0%
Target:  

HIF/HIF Prolyl-Hydroxylase VEGFR Autophagy

Research Areas:  

Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer

PX-478 is a multifunctional HIF-1α inhibitor with properties including radiosensitization, autophagy activation, and lipid accumulation inhibition. PX-478 also blocks hypoxia-induced VEGF production and regulates β-cell phenotypes under hypoxic conditions. PX-478 induces cell cycle arrest and DNA damage, restores autophagic function, reduces foam cell formation, and maintains glucose homeostasis. PX-478 is widely used in research on related diseases such as human tumors (e.g., prostate cancer), type 2 diabetes, and atherosclerosis .
66
Atorvastatin
Atorvastatin
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66 Cited Publications
Cat. No.: HY-B0589
CAS No.: 134523-00-5
Target:  

HMG-CoA Reductase (HMGCR) Autophagy

Research Areas:  

Metabolic Disease Inflammation/Immunology Cancer

Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively .
66
Atorvastatin hemicalcium salt
Atorvastatin hemicalcium salt
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66 Cited Publications
Cat. No.: HY-17379
CAS No.: 134523-03-8
Synonyms: CI-981; Atorvastatin hemicalcium
Target:  

HMG-CoA Reductase (HMGCR) Autophagy Ferroptosis

Research Areas:  

Metabolic Disease Inflammation/Immunology Cancer

Atorvastatin hemicalcium salt (CI-981) is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, with blood-brain barrier permeability. Atorvastatin hemicalcium salt has the ability to effectively decrease blood lipids. Atorvastatin hemicalcium salt inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively .
64
Atorvastatin sodium
Atorvastatin sodium
0 Images
64 Cited Publications
Cat. No.: HY-108257
CAS No.: 134523-01-6
Purity:  99.76%
Target:  

HMG-CoA Reductase (HMGCR) Autophagy

Research Areas:  

Metabolic Disease Inflammation/Immunology

Atorvastatin sodium is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin sodium inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively .
64
Atorvastatin hemicalcium trihydrate
Atorvastatin hemicalcium trihydrate
0 Images
64 Cited Publications
Cat. No.: HY-B0589E
CAS No.: 344920-08-7
Target:  

HMG-CoA Reductase (HMGCR) Autophagy

Research Areas:  

Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer

Atorvastatin hemicalcium trihydrate is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin hemicalcium trihydrate inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively .
60
Glycerol Monoleate
Glycerol Monoleate
0 Images
60 Cited Publications
Cat. No.: HY-N1446A
CAS No.: 25496-72-4
Category:  

Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite

Glycerol Monoleate is a non-toxic, biodegradable, biocompatible, lipophilic glycerol fatty acid ester. Glycerol Monoleate exhibits hemolytic properties. Glycerol Monoleate is combined with bile salts for use as an emulsifier and absorption enhancer. Glycerol Monoleate can be applied in drug delivery systems and in vitro siRNA delivery .
55
Arachidonic acid
Arachidonic acid
0 Images
55 Cited Publications
Cat. No.: HY-109590
CAS No.: 506-32-1
Purity:  99.73%
Synonyms: Immunocytophyt
Category:  

Human Gut Microbiota Metabolites Animals Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:  

Endogenous Metabolite

Arachidonic acid (Immunocytophyt) is a polyunsaturated omega-6 fatty acid and a major constituent of biomembranes. Arachidonic acid also acts as the substrate for various lipid mediators, such as prostaglandins (PGs). Arachidonic acid improves cognitive response and cardiovascular function .
55
Arachidonic acid sodium salt
Arachidonic acid sodium salt
0 Images
55 Cited Publications
Cat. No.: HY-109590A
CAS No.: 6610-25-9
Purity:  99.3%
Synonyms: Immunocytophyt sodium salt
Target:  

Endogenous Metabolite

Research Areas:  

Cardiovascular Disease Neurological Disease Inflammation/Immunology

Arachidonic acid (Immunocytophyt) sodium salt is a polyunsaturated omega-6 fatty acid and a major constituent of biomembranes. Arachidonic acid sodium salt also acts as the substrate for various lipid mediators, such as prostaglandins (PGs). Arachidonic acid sodium salt improves cognitive response and cardiovascular function .
52
Nystatin
Nystatin
0 Images
52 Cited Publications
Cat. No.: HY-17409
CAS No.: 1400-61-9
Category:  

Infection Microorganisms Macrolide Antibiotics Antifungal Antibiotics Mammalian Cell Culture Disease Research Disease Research Fields

Target:  

Fungal Antibiotic Apoptosis Bacterial

Nystatin is an orally active polyene antifungal antibiotic effective against yeast and mycoplasma. Nystatin increases the permeability of plasma membranes to small monovalent ions, including chloridion . Nystatin is a cholesterol-sequestering agent , partially prevents Oxaliplatin-induced lipid raft aggregation, DR4 and DR5 clustering, and thereby reduces apoptosis .
50
SM-102
SM-102
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50 Cited Publications
Cat. No.: HY-134541
CAS No.: 2089251-47-6
Purity:  99.97%
SM-102 is an amino cationic lipid useful in the formation of lipid nanoparticles (LNPs). SM-102 has higher transfection efficiency. SM-102 plays an important role in the effectiveness of lipid nanoparticles (LNPs) in delivering mRNA therapeutics and vaccines .
43
ALC-0315
ALC-0315
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43 Cited Publications
Cat. No.: HY-138170
CAS No.: 2036272-55-4
Purity:  99.81%
ALC-0315 is an ionisable aminolipid that is responsible for mRNA compaction and aids mRNA cellular delivery and its cytoplasmic release through suspected endosomal destabilization. ALC-0315 can be used to form lipid nanoparticle (LNP) delivery vehicles. Lipid-Nanoparticles have been used in the research of mRNA COVID-19 vaccine .
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