1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. 7α-Hydroxy-4-cholesten-3-one

7α-Hydroxy-4-cholesten-3-one 

Cat. No.: HY-113259
Handling Instructions

7α-Hydroxy-4-cholesten-3-one is an intermediate in synthesis of bile acids from cholesterol. 7α-Hydroxy-4-cholesten-3-one is a pregnane X receptor (PXR) agonist. 7α-Hydroxy-cholest-4-en-3-one is a biomarker for bile acid loss, irritable bowel syndrome, and other diseases associated with defective bile acid biosynthesis. 7α-Hydroxy-cholest-4-en-3-one is the physiological substrate for CYP8B1.

For research use only. We do not sell to patients.

7α-Hydroxy-4-cholesten-3-one Chemical Structure

7α-Hydroxy-4-cholesten-3-one Chemical Structure

CAS No. : 3862-25-7

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Description

7α-Hydroxy-4-cholesten-3-one is an intermediate in synthesis of bile acids from cholesterol. 7α-Hydroxy-4-cholesten-3-one is a pregnane X receptor (PXR) agonist. 7α-Hydroxy-cholest-4-en-3-one is a biomarker for bile acid loss, irritable bowel syndrome, and other diseases associated with defective bile acid biosynthesis. 7α-Hydroxy-cholest-4-en-3-one is the physiological substrate for CYP8B1[1][2].

IC50 & Target

Endogenous Metabolite[1]
Pregnane X receptor (PXR)[1]

In Vitro

7α-Hydroxy-4-cholesten-3-one is found relatively upstream in the biosynthetic pathway to bile acids (e.g. chenodeoxycholic acid). The first step is the incorporation of the 7α-hydroxy group onto cholesterol by cytochrome P450 7A1, and the second step is the oxidation and isomerization of the 3-hydroxy group and the Δ5,6-double bond by 3β-hydroxy steroid dehydrogenase to yield 7α-Hydroxy-4-cholesten-3-one. The deletion of the gene that expresses P450 27A1, which is found downstream in the bile acid pathway, results in the accumulation of the precursor, 7α-Hydroxy-4-cholesten-3-one[1].

In Vivo

7α-Hydroxy-4-cholesten-3-one strongly relates to the hepatic enzymatic activity of CYP7A1 at steady-state conditions as well as during the rapid diurnal changes that occur in the rat. That serum 7α-Hydroxy-4-cholesten-3-one has a pronounced diurnal rhythm[2].

Molecular Weight

400.64

Formula

C₂₇H₄₄O₂

CAS No.

3862-25-7

SMILES
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Keywords:

7α-Hydroxy-4-cholesten-3-oneEndogenous MetaboliteCYP7A17α-hydroxylaseintermediatebileacidscholesterolPXRCYP8B1oxysterolInhibitorinhibitorinhibit

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7α-Hydroxy-4-cholesten-3-one
Cat. No.:
HY-113259
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