2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. 8-Hydroxyguanine

8-Hydroxyguanine  (Synonyms: 8-Oxoguanine; 8-oxo-Gua)

Cat. No.: HY-113338 Pureté: 90.05%
COA
SDS
Instruction de manipulation Technical Support

8-Hydroxyguanine is a DNA damage product under oxidative stress, which is formed when hydroxyl radicals attack guanine in DNA. 8-Hydroxyguanine induces mutagenesis and leads to a transversion from G to T. 8-Hydroxyguanine is a marker of DNA oxidative damage.

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8-Hydroxyguanine

8-Hydroxyguanine Chemical Structure

CAS No. : 5614-64-2

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10 mg En stock
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Other Forms of 8-Hydroxyguanine:

8-Hydroxyguanine Related Antibodies

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Description

8-Hydroxyguanine is a DNA damage product under oxidative stress, which is formed when hydroxyl radicals attack guanine in DNA. 8-Hydroxyguanine induces mutagenesis and leads to a transversion from G to T. 8-Hydroxyguanine is a marker of DNA oxidative damage[1][2].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

The most common product of ROS-induced base damage is 8-Hydroxyguanine. Failure to promptly remove 8-Hydroxyguanine often causes mutations during DNA replication. 8-Hydroxyguanine is cleared from cells by the 8-oxoG DNA glycosylase 1 (OGG1)-mediated oxidative damage base excision repair pathway so as to prevent cells from suffering dysfunction due to oxidative stress[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

8-Hydroxyguanine Related Antibodies
Masse moléculaire

167.13

Formule

C5H5N5O2
CAS No.
Appearance

Solid

Color

Light brown to khaki

SMILES

O=C1NC(N)=NC2=C1NC(N2)=O
Structure Classification
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvant et solubilité
In Vitro: 

1M NaOH : 25 mg/mL (149.58 mM; ultrasonic and adjust pH to 12 with 1M NaOH)

H2O : 4.72 mg/mL (28.24 mM; ultrasonic and warming and adjust pH to 11 with NaOH and heat to 60°C)

Ethanol : < 1 mg/mL (insoluble)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

*8-Hydroxyguanine is usually formulated as a suspension.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.9834 mL 29.9168 mL 59.8337 mL
5 mM 1.1967 mL 5.9834 mL 11.9667 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Calculateur de molarité

  • Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Pureté et documentation

Purity: ≥98.0%

SDS (393 KB)

COA (247 KB)

Instruction de manipulation (2659 KB)
Références

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / 1M NaOH 1 mM 5.9834 mL 29.9168 mL 59.8337 mL 149.5842 mL
5 mM 1.1967 mL 5.9834 mL 11.9667 mL 29.9168 mL
10 mM 0.5983 mL 2.9917 mL 5.9834 mL 14.9584 mL
15 mM 0.3989 mL 1.9945 mL 3.9889 mL 9.9723 mL
20 mM 0.2992 mL 1.4958 mL 2.9917 mL 7.4792 mL
25 mM 0.2393 mL 1.1967 mL 2.3933 mL 5.9834 mL
1M NaOH 30 mM 0.1994 mL 0.9972 mL 1.9945 mL 4.9861 mL
40 mM 0.1496 mL 0.7479 mL 1.4958 mL 3.7396 mL
50 mM 0.1197 mL 0.5983 mL 1.1967 mL 2.9917 mL
60 mM 0.0997 mL 0.4986 mL 0.9972 mL 2.4931 mL
80 mM 0.0748 mL 0.3740 mL 0.7479 mL 1.8698 mL
100 mM 0.0598 mL 0.2992 mL 0.5983 mL 1.4958 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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8-Hydroxyguanine Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

8-Hydroxyguanine5614-64-28-Oxoguanine 8-oxo-GuaEndogenous MetaboliteInhibitorinhibitorinhibit

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