5614-64-2
5614-64-2
Chemical Structure
8-Hydroxyguanine
Synonym(s): 8-Oxoguanine; 8-oxo-Gua
- CAS No.: 5614-64-2
- Formula:C5H5N5O2
- Molecular Weight:167.13
IUPAC Name: 2-amino-7,9-dihydro-1H-purine-6,8-dione
InChIKey: CLGFIVUFZRGQRP-UHFFFAOYSA-N
SMILES: O=C1NC(N)=NC2=C1NC(N2)=O
Biological Activity: 8-Hydroxyguanine is a DNA damage product under oxidative stress, which is formed when hydroxyl radicals attack guanine in DNA. 8-Hydroxyguanine induces mutagenesis and leads to a transversion from G to T. 8-Hydroxyguanine is a marker of DNA oxidative damage[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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8-Hydroxyguanine | 90.05% | 8-Hydroxyguanine is a DNA damage product under oxidative stress, which is formed when hydroxyl radicals attack guanine in DNA. 8-Hydroxyguanine induces mutagenesis and leads to a transversion from G to T. 8-Hydroxyguanine is a marker of DNA oxidative damage. | ||||||||||||||||||||
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References
- [1]. Spencer JP, et al., DNA strand breakage and base modification induced by hydrogen peroxide treatment of human respiratory tract epithelial cells. FEBS Lett. 1995 Oct 30;374(2):233-6. [Content Brief]
- [2]. Zhang W, et al. Effect of 8-Hydroxyguanine DNA Glycosylase 1 on the Function of Immune Cells. Antioxidants (Basel). 2023 Jun 19;12(6):1300. [Content Brief]
