1. PROTAC
  2. PROTAC

AT6 

Cat. No.: HY-112375
Handling Instructions

AT6 is a PROTAC AT1 analogue, which is a highly selective bromodomain (Brd4) degrader.

For research use only. We do not sell to patients.

AT6 Chemical Structure

AT6 Chemical Structure

CAS No. : 2098836-50-9

Size Price Stock
5 mg USD 550 Get quote
10 mg USD 850 Get quote
25 mg USD 1600 Get quote

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

AT6 is a PROTAC AT1 analogue, which is a highly selective bromodomain (Brd4) degrader.

In Vitro

PROTACs (proteolysis-targeting chimaeras) are bifunctional molecules that recruit a target protein in proximity to an E3 ubiquitin ligase to trigger protein degradation. Structural elucidation of the key ternary ligase: PROTAC: target species and how this impacts target degradation selectivity remains elusive. The ligand folds into itself to allow formation of specific intermolecular interactions in the ternary complex. Isothermal titration calorimetry studies, supported by surface mutagenesis and proximity assays, are consistent with pronounced cooperative formation of ternary complexes with Brd4BD2. Structure-based-designed compound AT1 exhibits highly selective depletion of Brd4 in cells[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9953 mL 4.9767 mL 9.9534 mL
5 mM 0.1991 mL 0.9953 mL 1.9907 mL
10 mM 0.0995 mL 0.4977 mL 0.9953 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

1004.68

Formula

C₄₈H₅₈ClN₉O₇S₃

CAS No.

2098836-50-9

SMILES

CC1=C(C)C(C(C2=CC=C(Cl)C=C2)=N[[email protected]@H](CC(NCCOCCOCCSC(C)(C)[[email protected]](NC(C)=O)C(N3C[[email protected]](O)C[[email protected]]3C(NCC4=CC=C(C5=C(C)N=CS5)C=C4)=O)=O)=O)C6=NN=C(C)N67)=C7S1

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
AT6
Cat. No.:
HY-112375
Quantity:

AT6

Cat. No.: HY-112375