1. PROTAC
  2. PROTAC
  3. AT6

AT6 

Cat. No.: HY-112375
Handling Instructions

AT6 is a PROTAC AT1 analogue, which is a highly selective bromodomain (Brd4) degrader.

For research use only. We do not sell to patients.

AT6 Chemical Structure

AT6 Chemical Structure

CAS No. : 2098836-50-9

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Description

AT6 is a PROTAC AT1 analogue, which is a highly selective bromodomain (Brd4) degrader.

In Vitro

PROTACs (proteolysis-targeting chimaeras) are bifunctional molecules that recruit a target protein in proximity to an E3 ubiquitin ligase to trigger protein degradation. Structural elucidation of the key ternary ligase: PROTAC: target species and how this impacts target degradation selectivity remains elusive. The ligand folds into itself to allow formation of specific intermolecular interactions in the ternary complex. Isothermal titration calorimetry studies, supported by surface mutagenesis and proximity assays, are consistent with pronounced cooperative formation of ternary complexes with Brd4BD2. Structure-based-designed compound AT1 exhibits highly selective depletion of Brd4 in cells[1].

Molecular Weight

1004.68

Formula

C₄₈H₅₈ClN₉O₇S₃

CAS No.

2098836-50-9

SMILES

CC1=C(C)C(C(C2=CC=C(Cl)C=C2)=N[[email protected]@H](CC(NCCOCCOCCSC(C)(C)[[email protected]](NC(C)=O)C(N3C[[email protected]](O)C[[email protected]]3C(NCC4=CC=C(C5=C(C)N=CS5)C=C4)=O)=O)=O)C6=NN=C(C)N67)=C7S1

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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