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  3. AT6

AT6 

Cat. No.: HY-112375
Handling Instructions

AT6 is a PROTAC AT1 analogue, which is a highly selective bromodomain (Brd4) degrader.

For research use only. We do not sell to patients.

AT6 Chemical Structure

AT6 Chemical Structure

CAS No. : 2098836-50-9

Size Price Stock Quantity
1 mg USD 300 In-stock
Estimated Time of Arrival: December 31
5 mg USD 650 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1050 In-stock
Estimated Time of Arrival: December 31
25 mg USD 2150 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

AT6 is a PROTAC AT1 analogue, which is a highly selective bromodomain (Brd4) degrader.

In Vitro

PROTACs (proteolysis-targeting chimaeras) are bifunctional molecules that recruit a target protein in proximity to an E3 ubiquitin ligase to trigger protein degradation. Structural elucidation of the key ternary ligase: PROTAC: target species and how this impacts target degradation selectivity remains elusive. The ligand folds into itself to allow formation of specific intermolecular interactions in the ternary complex. Isothermal titration calorimetry studies, supported by surface mutagenesis and proximity assays, are consistent with pronounced cooperative formation of ternary complexes with Brd4BD2. Structure-based-designed compound AT1 exhibits highly selective depletion of Brd4 in cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1004.68

Formula

C₄₈H₅₈ClN₉O₇S₃

CAS No.
SMILES

CC1=C(C)C(C(C2=CC=C(Cl)C=C2)=N[[email protected]@H](CC(NCCOCCOCCSC(C)(C)[[email protected]](NC(C)=O)C(N3C[[email protected]](O)C[[email protected]]3C(NCC4=CC=C(C5=C(C)N=CS5)C=C4)=O)=O)=O)C6=NN=C(C)N67)=C7S1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (99.53 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9953 mL 4.9767 mL 9.9534 mL
5 mM 0.1991 mL 0.9953 mL 1.9907 mL
10 mM 0.0995 mL 0.4977 mL 0.9953 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 5 mg/mL (4.98 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 5 mg/mL (4.98 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 5 mg/mL (4.98 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

AT6AT 6AT-6PROTACProteolysis-targeting chimeraInhibitorinhibitorinhibit

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Product Name:
AT6
Cat. No.:
HY-112375
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