2. Immunology/Inflammation Apoptosis Autophagy
  3. PD-1/PD-L1 Apoptosis Autophagy
  4. Atezolizumab

Atezolizumab  (Synonyms: MPDL3280A; RG-7446; RO-5541267)

Cat. No.: HY-P9904 Pureza: 99.9%
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SDS
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Atezolizumab (MPDL3280A) is a selective humanized monoclonal IgG1 antibody against programmed death ligand 1 (PD-L1), used for cancer research.

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No. CAS : 1380723-44-3

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Revisión del cliente

Based on 36 publication(s) in Google Scholar

Atezolizumab Recomendaciones destacadas:

Atezolizumab Related Antibodies

Top Publications Citing Use of Products

36 Publications Citing Use of MCE Atezolizumab

Histological Imaging/Staining
In Vivo Imaging
In Vivo Efficacy Study
Flow Cytometry
WB

    Atezolizumab purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Nov 18;16(1):10096.  [Abstract]

    Atezolizumab (4 mg/kg; i.v.) + Bevacizumab (1 mg/kg; i.v.), every other day for 14 days (G4 group) in PDX subcutaneous mouse model. Collected tumor tissues of mice at the end of treatment in different groups.

    Atezolizumab purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Nov 18;16(1):10096.  [Abstract]

    Atezolizumab (4mg/kg; i.v.) + Bevacizumab (1mg/kg; i.v.), every other day for 14 days (G4 group) in PDX subcutaneous mouse model. Flow cytometric analysis of anti-CD68/CD206-stained macrophages (gated on CD45+ cells), anti-CD68/CD80-stained macrophages (gated on CD45+ cells),anti-HLA-DR/CD11c-stained DCs (gated on CD45+ Lin-1- T cells), and anti-CD3/CD8-stained T cells (gated on CD45+ cells) in tumor tissues after different treatments (n = 5 independent mice).

    Atezolizumab purchased from MedChemExpress. Usage Cited in: Nat Nanotechnol. 2025 Feb;20(2):296-302.  [Abstract]

    PD-L1 expression levels in 293T cells overexpressing PD-L1 after treatment with 500 nM ATZ and ATZ-NPs for 24 h. Vinculin (VINC) was utilized as a loading control.

    Atezolizumab purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 May 22:e2309992.  [Abstract]

    Atezolizumab (100 μg/mouse; i.p.; at days 2, 4, and 6). H&E staining, cleaved-caspase 3, Ki 67, CXCR4 and PD-L1 IHC staining images of tumor slices after various treatments. Group A received PBS. Group B received PBS + ICT (Atezolizumab). Group C received RENPs + ICT. Group D received PBS + RT + ICT. Group E received RENPs + RT + ICT.

    Atezolizumab purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 May 22:e2309992.  [Abstract]

    Atezolizumab (100 μg/mouse; i.p.; at days 2, 4, and 6). Images of mice and excised tumor after different treatments. Group A received PBS. Group B received PBS + ICT (Atezolizumab). Group C received RENPs + ICT. Group D received PBS + RT + ICT. Group E received RENPs + RT + ICT.

    Atezolizumab purchased from MedChemExpress. Usage Cited in: EJNMMI Res. 2020 Jun 15;10(1):64.  [Abstract]

    Western blot analysis of total cell lysates using anti-PD-L1 (Atezolizumab, 6.91 nM) and anti-β-actin antibody between LoVo, LS174T, SW620, and RKO in vitro.

    • Actividad biológica

    • Pureza y Documentación

    • Referencias

    • Revisión del cliente

    Descripciòn

    Atezolizumab (MPDL3280A) is a selective humanized monoclonal IgG1 antibody against programmed death ligand 1 (PD-L1), used for cancer research.

    Isotype

    Human IgG1 kappa
    Recommend Isotype Controls
    Species Reactivity

    Human
    IC50 & Target

    B7-H1/PD-L1/CD274
    In Vitro

    Atezolizumab (0, 2.5, 5, 10, 20, and 40 μg/ml; 24 hours; HOS and 143B cells) inhibits proliferation and induces immune-independent apoptosis of osteosarcoma cells[1].
    Atezolizumab impairs the function of mitochondria to cause the imbalance between oxidants and antioxidants. Atezolizumab induces mitochondria-related apoptosis of osteosarcoma cells by activating JNK pathway[1].
    Atezolizumab (10 μg/ml; 24 hours; HOS and 143B cells) induces autophagy in osteosarcoma cells[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Atezolizumab Related Antibodies
    Ensayo clínico
    Gene ID

    29126  [NCBI]

    Accession
    Application

    ELISA, FACS, Functional assay
    Conjugated

    Unconjugated
    Reconsititution

    The product can be reconstituted/diluted with sterile PBS or saline.
    Peso molecular

    144.6 kDa

    No. CAS
    Appearance

    Liquid

    Color

    Colorless to light yellow

    SMILES

    [Atezolizumab]
    Envío

    Shipping with dry ice.
    Formulation

    Please refer to the lot-specific COA for specific buffer information.
    Almacenamiento

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Format
    • Human IgG1 kappa
    Biological Activity
    • Immobilized PD-L1 Protein, Human (HEK293) can bind Atezolizumab. The EC 50 for this effect is 10.9 ng/mL.
    • Flow cytometry analysis of PD-L1 overexpression HEK293 cells labelling PD-L1 with Atezolizumab at 67nM (Red). Goat anti human IgG Fc (Alexa Fluor488) was used as the secondary antibody at 1/400 dilution. Isotype control - human IgG (Blue). Unlabeled control - Unlabelled cells (Gray).
    Pureza y Documentación

    Purity: 99.9%

    SDS (252 KB)

    COA (232 KB) SDS-PAGE (64 KB) SEC-HPLC (124 KB)

    Inhibitory Antibodies User Guide (603 KB)
    Referencias
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    • If you have published this work, please enter the PubMed ID.
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    Atezolizumab Related Classifications

    • Calculadora de molaridad

    • Calculadora de dilución

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Atezolizumab1380723-44-3MPDL3280A RG-7446 RO-5541267RG7446RG 7446RG-7446RO5541267RO 5541267RO-5541267PD-1/PD-L1ApoptosisAutophagyPD-1/Programmed death-ligand 1Inhibitorinhibitorinhibit

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    Inquiry Information

    Nombre del producto:
    Atezolizumab
    Cat. No.:
    HY-P9904
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