Bremelanotide Acetate (Synonyms: PT-141 Acetate)

Name: Bremelanotide Acetate
Brand: MedChemExpress
SKU: HY-18678A
Rating: 4.5 (1 reviews)

Cat. No.: HY-18678A Purity: 99.94%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Bremelanotide (PT-141) Acetate is a melanocortin receptor agonist. Bremelanotide Acetate can activate MC4R and increases dopamine release. Bremelanotide Acetate induces appetitive sexual behaviors, female mounting behavior, and repetitive self-grooming. Bremelanotide Acetate can be used for the research of hypoactive sexual desire disorders.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Custom Peptide Synthesis

Bremelanotide Acetate 화학구조

CAS No. : 1607799-13-2

사이즈	재고	수량
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 publication(s) in Google Scholar

Other Forms of Bremelanotide Acetate:

Bremelanotide In-stock

1 Publications Citing Use of MCE Bremelanotide Acetate

•Mol Pharm. 2022 Nov 7;19(11):4320-4332. [Abstract]

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Melanocortin Receptor Isoform Specific Products:

View All Isoforms

MC1R MC3R MC2R MC4R MC5R

Biological Activity
순도&문서
References
고객리뷰

제품 설명

IC₅₀ & Target

MC3R

MC4R

In Vitro

Bremelanotide (10⁻³-10⁵ nM) Acetate binds to MC3R and MC4R in a concentration-dependent manner^[3].
Bremelanotide Acetate induces cAMP accumulation in cell-free assays with EC₅₀ values of 0.4 nM for MC3R and 0.2 nM for MC4R^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Bremelanotide (50-200 μg/kg; s.c.) Acetate selectively increases appetitive sexual behaviors (solicitations, hops and darts) in hormone-primed ovariectomized female rats via activation of MC4R and dopamine release in the medial preoptic area^[1].
Bremelanotide (0.01-10 mg/kg; i.p.; single dose) Acetate induces dose-dependent repetitive grooming behavior in male and female mice, with 1 mg/kg being the lowest effective grooming dose that does not cause anxiety-like behavior^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female rats (ovariectomized, hormone-primed with estradiol and progesterone, or estradiol alone)^[1]
Dosage:	50, 100, 200 μg/kg
Administration:	Subcutaneously injection
Result:	Increased solicitations in estradiol + progesterone-primed rats at 100 and 200 μg/kg. Increased solicitations in estradiol-alone primed rats at 200 μg/kg. Increased hops and darts in estradiol + progesterone-primed rats at 100 and 200 μg/kg. Induced female mounting behavior at 200 μg/kg.

Clinical Trial

분자량

1085.22

화학식

C₅₂H₇₂N₁₄O₁₂

CAS No.

1607799-13-2

Appearance

Solid

Color

White to off-white

Sequence

Ac-[Nle}-Asp-His-{d-Phe}-Arg-Trp-Lys (Lactam bridge: Asp4-Lys7)

Sequence Shortening

Ac-[Nle}-DHFRWK (Lactam bridge: Asp4-Lys7)

선적

Room temperature in continental US; may vary elsewhere.

보관

Sealed storage, away from moisture and light, under nitrogen

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

용액&용해도

In Vitro:

DMSO : 100 mg/mL (92.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : ≥ 50 mg/mL (46.07 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.9215 mL	4.6074 mL	9.2147 mL
5 mM	0.1843 mL	0.9215 mL	1.8429 mL
10 mM	0.0921 mL	0.4607 mL	0.9215 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (1.92 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (1.92 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (1.92 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

순도&문서

Purity: 99.97%

Select Batch:

Data Sheet (281 KB) SDS (252 KB)

COA (255 KB) HNMR (197 KB) LCMS (108 KB)

Handling Instructions (2659 KB)

References

[1]. Pfaus J, et al. Bremelanotide: an overview of preclinical CNS effects on female sexual function. J Sex Med. 2007;4 Suppl 4:269-279. [Content Brief]

[2]. Harberson M T, et al. Bremelanotide, a Medication for Hypoactive Sexual Desire Disorder, Promotes Repetitive Self-grooming and Avoidance Behavior in Mice[D]. The University of Toledo, 2024.

[3]. Molinoff PB, et al. PT-141: a melanocortin agonist for the treatment of sexual dysfunction. Ann N Y Acad Sci. 2003 Jun;994:96-102. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	0.9215 mL	4.6074 mL	9.2147 mL	23.0368 mL
	5 mM	0.1843 mL	0.9215 mL	1.8429 mL	4.6074 mL
	10 mM	0.0921 mL	0.4607 mL	0.9215 mL	2.3037 mL
	15 mM	0.0614 mL	0.3072 mL	0.6143 mL	1.5358 mL
	20 mM	0.0461 mL	0.2304 mL	0.4607 mL	1.1518 mL
	25 mM	0.0369 mL	0.1843 mL	0.3686 mL	0.9215 mL
	30 mM	0.0307 mL	0.1536 mL	0.3072 mL	0.7679 mL
	40 mM	0.0230 mL	0.1152 mL	0.2304 mL	0.5759 mL
DMSO	50 mM	0.0184 mL	0.0921 mL	0.1843 mL	0.4607 mL
	60 mM	0.0154 mL	0.0768 mL	0.1536 mL	0.3839 mL
	80 mM	0.0115 mL	0.0576 mL	0.1152 mL	0.2880 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Bremelanotide Acetate Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bremelanotide1607799-13-2PT-141PT141PT 141Melanocortin ReceptorMC ReceptorInhibitorinhibitorinhibit

최근 본 상품:

상품명

Requested Quantity *

고객명 *

호칭

메일주소 *

전화번호 *

Department

회사명 *

City

도

Country or Region *

비고

상품명

Lot #

고객명 *

메일주소 *

전화번호

Department *

회사명 *

Country or Region *

비고

Name
이메일 *

	Sorry, but the email address you supplied was invalid.

Bremelanotide Acetate (Synonyms: PT-141 Acetate)

고객리뷰

Other Forms of Bremelanotide Acetate:

Bremelanotide Acetate Related Antibodies

1 Publications Citing Use of MCE Bremelanotide Acetate

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Melanocortin Receptor Isoform Specific Products:

Biological Activity

순도&문서

References

고객리뷰

Bremelanotide Acetate Related Antibodies

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

Bremelanotide Acetate Related Classifications

Keywords:

최근 본 상품:

고객리뷰

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report