2. GPCR/G Protein Neuronal Signaling
  3. Melanocortin Receptor
  4. Bremelanotide Acetate

Bremelanotide Acetate  (Synonyms: PT-141 Acetate)

製品番号: HY-18678A 純度: 99.94%
COA 取扱説明書 Technical Support

Bremelanotide (PT-141) Acetate is a melanocortin receptor agonist. Bremelanotide Acetate can activate MC4R and increases dopamine release. Bremelanotide Acetate induces appetitive sexual behaviors, female mounting behavior, and repetitive self-grooming. Bremelanotide Acetate can be used for the research of hypoactive sexual desire disorders.

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Bremelanotide Acetate

Bremelanotide Acetate 構造式

CAS 番号 : 1607799-13-2

容量 価格（税別） 在庫状況 数量
5 mg $42 在庫あり
10 mg $66 在庫あり
25 mg $132 在庫あり
50 mg $198 在庫あり
100 mg $250 在庫あり
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500 mg   お問い合わせ  

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Based on 1 publication(s) in Google Scholar

Other Forms of Bremelanotide Acetate:

Bremelanotide Acetate 関連抗体

Top Publications Citing Use of Products

Melanocortin Receptor アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
MC1R MC3R MC2R MC4R MC5R

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

Bremelanotide (PT-141) Acetate is a melanocortin receptor agonist. Bremelanotide Acetate can activate MC4R and increases dopamine release. Bremelanotide Acetate induces appetitive sexual behaviors, female mounting behavior, and repetitive self-grooming. Bremelanotide Acetate can be used for the research of hypoactive sexual desire disorders[1][2][3].

IC50 & Target

MC3R

 

MC4R

 

体外実験

Bremelanotide (10−3-105 nM) Acetate binds to MC3R and MC4R in a concentration-dependent manner[3].
Bremelanotide Acetate induces cAMP accumulation in cell-free assays with EC50 values of 0.4 nM for MC3R and 0.2 nM for MC4R[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bremelanotide Acetate 関連抗体
体内実験

Bremelanotide (50-200 μg/kg; s.c.) Acetate selectively increases appetitive sexual behaviors (solicitations, hops and darts) in hormone-primed ovariectomized female rats via activation of MC4R and dopamine release in the medial preoptic area[1].
Bremelanotide (0.01-10 mg/kg; i.p.; single dose) Acetate induces dose-dependent repetitive grooming behavior in male and female mice, with 1 mg/kg being the lowest effective grooming dose that does not cause anxiety-like behavior[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female rats (ovariectomized, hormone-primed with estradiol and progesterone, or estradiol alone)[1]
Dosage: 50, 100, 200 μg/kg
Administration: Subcutaneously injection
Result: Increased solicitations in estradiol + progesterone-primed rats at 100 and 200 μg/kg.
Increased solicitations in estradiol-alone primed rats at 200 μg/kg.
Increased hops and darts in estradiol + progesterone-primed rats at 100 and 200 μg/kg.
Induced female mounting behavior at 200 μg/kg.
臨床実験
分子量

1085.22

分子式

C52H72N14O12
CAS 番号
Appearance

Solid

Color

White to off-white

Sequence

Ac-[Nle}-Asp-His-{d-Phe}-Arg-Trp-Lys (Lactam bridge: Asp4-Lys7)
Sequence Shortening

Ac-[Nle}-DHFRWK (Lactam bridge: Asp4-Lys7)
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

polypeptide, sealed storage, away from moisture and light, under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (polypeptide, sealed storage, away from moisture and light, under nitrogen)
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (92.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : ≥ 50 mg/mL (46.07 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9215 mL 4.6074 mL 9.2147 mL
5 mM 0.1843 mL 0.9215 mL 1.8429 mL
10 mM 0.0921 mL 0.4607 mL 0.9215 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (1.92 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (1.92 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.97%

COA (255 KB) HNMR (197 KB) LCMS (108 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 0.9215 mL 4.6074 mL 9.2147 mL 23.0368 mL
5 mM 0.1843 mL 0.9215 mL 1.8429 mL 4.6074 mL
10 mM 0.0921 mL 0.4607 mL 0.9215 mL 2.3037 mL
15 mM 0.0614 mL 0.3072 mL 0.6143 mL 1.5358 mL
20 mM 0.0461 mL 0.2304 mL 0.4607 mL 1.1518 mL
25 mM 0.0369 mL 0.1843 mL 0.3686 mL 0.9215 mL
30 mM 0.0307 mL 0.1536 mL 0.3072 mL 0.7679 mL
40 mM 0.0230 mL 0.1152 mL 0.2304 mL 0.5759 mL
DMSO 50 mM 0.0184 mL 0.0921 mL 0.1843 mL 0.4607 mL
60 mM 0.0154 mL 0.0768 mL 0.1536 mL 0.3839 mL
80 mM 0.0115 mL 0.0576 mL 0.1152 mL 0.2880 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Bremelanotide Acetate Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bremelanotide1607799-13-2PT-141PT141PT 141Melanocortin ReceptorMC ReceptorInhibitorinhibitorinhibit

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