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    Autophagy
  2. Bacterial
    Autophagy
    Antibiotic
  3. Colistin sulfate

Colistin sulfate (Synonyms: Polymyxin E Sulfate)

Cat. No.: HY-A0089 Purity: >98.0%
Handling Instructions

Colistin sulfate is a polypeptide antibiotic which inhibits gram-negative bacteria by binding to lipopolysaccharides and phospholipids in the outer cell membrane of gram-negative bacteria.

For research use only. We do not sell to patients.

Colistin sulfate Chemical Structure

Colistin sulfate Chemical Structure

CAS No. : 1264-72-8

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10 mM * 1 mL in Water USD 66 In-stock
Estimated Time of Arrival: December 31
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
500 mg USD 96 In-stock
Estimated Time of Arrival: December 31
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Based on 3 publication(s) in Google Scholar

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Description

Colistin sulfate is a polypeptide antibiotic which inhibits gram-negative bacteria by binding to lipopolysaccharides and phospholipids in the outer cell membrane of gram-negative bacteria.

In Vitro

Colistins are bactericidal to gram-negative bacteria by a detergent-like mechanism. This mechanism involves interaction with lipopolysaccharides and phospholipids of the outer membrane and electrostatic interference with the outer membrane by competitively displacing divalent cations (calcium and magnesium) from the negatively charged phosphate groups of membrane lipids[1]. Colistin (polymyxin E) owns favorable properties of rapid bacterial killing, a narrow spectrum of activity, and an associated slow development of resistance for the treatment of infections caused by multidrug-resistant gram-negative bacteria. There are two forms of colistin available commercially: colistin (sulfate) mainly for topical use and colistin methanesulfonate (sodium) for parenteral use[2].

In Vivo

High concentrations of colistin in rat ELF are achieved as a result of slow and sustained CMS conversion following i.t. instillation[3]. Colistin is often used in piglets but underdosing and overdosing are frequent. Under- or overdoses of colistin do not result in any major disturbance of piglet fecal microbiota and rarely select for chromosomal resistance in the dominant E. coli population[4].

Clinical Trial
Molecular Weight

1253.51

Formula

C₅₂H₁₀₀N₁₆O₁₇S

CAS No.

1264-72-8

SMILES

CCC(C)CCCC(N[[email protected]@H](CCN)C(N[[email protected]](C(N[[email protected]](C(N[[email protected]@H](CCNC([[email protected]]([[email protected]](O)C)N1)=O)C(N[[email protected]@H](CCN)C(N[[email protected]](CC(C)C)C(N[[email protected]@H](CC(C)C)C(N[[email protected]@H](CCN)C(N[[email protected]@H](CCN)C1=O)=O)=O)=O)=O)=O)=O)CCN)=O)[[email protected]](O)C)=O)=O.O=S(O)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 32 mg/mL (25.53 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7978 mL 3.9888 mL 7.9776 mL
5 mM 0.1596 mL 0.7978 mL 1.5955 mL
10 mM 0.0798 mL 0.3989 mL 0.7978 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[3]

Rats: Colistin methanesulfonate (sodium) and colistin (sulfate) dosing solutions are freshly prepared in sterile 0.9% sodium chloride. For the i.v. studies, colistin methanesulfonate (CMS) or sulfate solutions are administered by a bolus injection via the jugular vein cannula. Intratracheal (i.t.) instillation is utilized as the technique for pulmonary administration. Animals are administered i.v. CMS at doses of 14 mg/kg of body weight, 28 mg/kg or 56 mg/kg. In an independent study, rats are administered i.v. colistin at doses of 0.21 mg/kg, 0.41 mg/kg, or 0.62 mg/kg[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

Purity: >98.0%

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Keywords:

ColistinPolymyxin EBacterialAutophagyAntibioticInhibitorinhibitorinhibit

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Colistin sulfate
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