2. Anti-infection Autophagy
  3. Bacterial Autophagy Antibiotic
  4. Colistin sulfate

Colistin sulfate  (Synonyms: Polymyxin E sulfate)

Cat. No.: HY-A0089 Purity: 98.0%
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Colistin sulfate is a polypeptide antibiotic which inhibits gram-negative bacteria by binding to lipopolysaccharides and phospholipids in the outer cell membrane of gram-negative bacteria.

For research use only. We do not sell to patients.

CAS No. : 1264-72-8

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Based on 27 publication(s) in Google Scholar

Other Forms of Colistin sulfate:

Colistin sulfate Related Antibodies

Top Publications Citing Use of Products
In Vivo Efficacy Study
Histological Imaging/Staining
RT-PCR
Microbiological Assay

    Colistin sulfate purchased from MedChemExpress. Usage Cited in: Arthritis Res Ther. 2025 Jul 7;27(1):137.  [Abstract]

    Colistin sulfate (150 mg/L; 12 weeks). The colonic tissue IF results showed significantly decreased expression of Occludin and, in particular, ZO-1 in the colistin and E. coli groups.

    Colistin sulfate purchased from MedChemExpress. Usage Cited in: Arthritis Res Ther. 2025 Jul 7;27(1):137.  [Abstract]

    Colistin sulfate (150 mg/L; 12 weeks). Significantly decreased mRNA expression of Occludin and ZO-1 was observed in the colistin and E. coli groups compared with the control group.

    Colistin sulfate purchased from MedChemExpress. Usage Cited in: Arthritis Res Ther. 2025 Jul 7;27(1):137.  [Abstract]

    Colistin sulfate (150 mg/L; 12 weeks) was administered. Representative images of H&E, Safranin O, AB, and TB staining of the mice tibial plateau from the three groups at 12 weeks were obtained.

    Colistin sulfate purchased from MedChemExpress. Usage Cited in: Arthritis Res Ther. 2025 Jul 7;27(1):137.  [Abstract]

    Colistin sulfate (150 mg/L; 12 weeks). IFP-SM IF revealed that the expression of CD86 increased in the colistin and E. coli groups.

    Colistin sulfate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Sep 10;15(1):7914.  [Abstract]

    The relative levels of serum anti-OVA IgA, cecal content anti-OVA IgA, serum total IgA, and cecal content total IgA of control (Ctrl) and T. mu-colonized mice with or without NA+ Colistin sulfate (600μg/mouse) treatments were determined 14 days after intraperitoneal immunization.

    Colistin sulfate purchased from MedChemExpress. Usage Cited in: Microorganisms. 2024 Mar 13;12(3):575.

    Percentages of E. coli strains showing antimicrobial resistance to different antimicrobial agents. AMP, Ampicillin; CAZ, Ceftazidime; IPM, Imipenem; MRP, Meropenem; GEN, Gentamicin; OFX, Ofloxacin; SXT, Trimethoprim–sulfamethoxazole; TET, Tetracycline; TGC, Tigecycline; CL, Colistin; FFC, Florfenicol.

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    • Biological Activity

    • Protocol

    • Purity & Documentation

    • References

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    Description

    Colistin sulfate is a polypeptide antibiotic which inhibits gram-negative bacteria by binding to lipopolysaccharides and phospholipids in the outer cell membrane of gram-negative bacteria.

    In Vitro

    Colistins are bactericidal to gram-negative bacteria by a detergent-like mechanism. This mechanism involves interaction with lipopolysaccharides and phospholipids of the outer membrane and electrostatic interference with the outer membrane by competitively displacing divalent cations (calcium and magnesium) from the negatively charged phosphate groups of membrane lipids[1]. Colistin (polymyxin E) owns favorable properties of rapid bacterial killing, a narrow spectrum of activity, and an associated slow development of resistance for the treatment of infections caused by multidrug-resistant gram-negative bacteria. There are two forms of colistin available commercially: colistin (sulfate) mainly for topical use and colistin methanesulfonate (sodium) for parenteral use[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Colistin sulfate Related Antibodies
    In Vivo

    High concentrations of colistin in rat ELF are achieved as a result of slow and sustained CMS conversion following i.t. instillation[3]. Colistin is often used in piglets but underdosing and overdosing are frequent. Under- or overdoses of colistin do not result in any major disturbance of piglet fecal microbiota and rarely select for chromosomal resistance in the dominant E. coli population[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    [H][C@@]([C@@H](C)O)(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](NC([C@@H](N1)CCN)=O)CC(C)C)=O)CC(C)C)=O)CCN)=O)CCN)=O)C(NCC[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CCC[R])=O)CCN)=O)[C@@H](C)O)=O)CCN)=O)C1=O)=O.[C]C(C)C.[C][C@H](CC)C.O=S(O)(O)=O.[R:].[R:].[Colistin B].[Colistin A].[2.5]
    Structure Classification
    Initial Source

    Bacillus polymyxa var. colistinus
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : 50 mg/mL (Need ultrasonic)

    DMSO : < 1 mg/mL (insoluble or slightly soluble)

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    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 50 mg/mL; Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
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    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 98.0%

    SDS (480 KB)

    COA (252 KB) HNMR (397 KB) MS (70 KB)

    Handling Instructions (2659 KB)
    References
    Animal Administration
    [3]

    Rats: Colistin methanesulfonate (sodium) and colistin (sulfate) dosing solutions are freshly prepared in sterile 0.9% sodium chloride. For the i.v. studies, colistin methanesulfonate (CMS) or sulfate solutions are administered by a bolus injection via the jugular vein cannula. Intratracheal (i.t.) instillation is utilized as the technique for pulmonary administration. Animals are administered i.v. CMS at doses of 14 mg/kg of body weight, 28 mg/kg or 56 mg/kg. In an independent study, rats are administered i.v. colistin at doses of 0.21 mg/kg, 0.41 mg/kg, or 0.62 mg/kg[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    References
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    Colistin sulfate Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Colistin1264-72-8Polymyxin EBacterialAutophagyAntibioticInhibitorinhibitorinhibit

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