2. Anti-infection
  3. Antibiotic Bacterial
  4. Colistin

Colistin is an orally active polypeptide antibiotic. Colistin has excellent activity against various Gram-negative rod-shaped bacteria, including multidrug-resistant Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae. Colistin is associated with nephrotoxicity. Colistin can be used for the research of infections caused by Gram-negative bacilli.

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (Colistin sulfate) that retains the same biological activity.

For research use only. We do not sell to patients.

CAS No. : 1066-17-7

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Colistin Related Antibodies

Top Publications Citing Use of Products
In Vivo Efficacy Study
Histological Imaging/Staining
RT-PCR
Microbiological Assay

    Colistin purchased from MedChemExpress. Usage Cited in: Arthritis Res Ther. 2025 Jul 7;27(1):137.  [Abstract]

    Colistin sulfate (150 mg/L; 12 weeks). The colonic tissue IF results showed significantly decreased expression of Occludin and, in particular, ZO-1 in the colistin and E. coli groups.

    Colistin purchased from MedChemExpress. Usage Cited in: Arthritis Res Ther. 2025 Jul 7;27(1):137.  [Abstract]

    Colistin sulfate (150 mg/L; 12 weeks). Significantly decreased mRNA expression of Occludin and ZO-1 was observed in the colistin and E. coli groups compared with the control group.

    Colistin purchased from MedChemExpress. Usage Cited in: Arthritis Res Ther. 2025 Jul 7;27(1):137.  [Abstract]

    Colistin sulfate (150 mg/L; 12 weeks) was administered. Representative images of H&E, Safranin O, AB, and TB staining of the mice tibial plateau from the three groups at 12 weeks were obtained.

    Colistin purchased from MedChemExpress. Usage Cited in: Arthritis Res Ther. 2025 Jul 7;27(1):137.  [Abstract]

    Colistin sulfate (150 mg/L; 12 weeks). IFP-SM IF revealed that the expression of CD86 increased in the colistin and E. coli groups.

    Colistin purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Sep 10;15(1):7914.  [Abstract]

    The relative levels of serum anti-OVA IgA, cecal content anti-OVA IgA, serum total IgA, and cecal content total IgA of control (Ctrl) and T. mu-colonized mice with or without NA+ Colistin sulfate (600μg/mouse) treatments were determined 14 days after intraperitoneal immunization.

    Colistin purchased from MedChemExpress. Usage Cited in: Microorganisms. 2024 Mar 13;12(3):575.

    Percentages of E. coli strains showing antimicrobial resistance to different antimicrobial agents. AMP, Ampicillin; CAZ, Ceftazidime; IPM, Imipenem; MRP, Meropenem; GEN, Gentamicin; OFX, Ofloxacin; SXT, Trimethoprim–sulfamethoxazole; TET, Tetracycline; TGC, Tigecycline; CL, Colistin; FFC, Florfenicol.

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    Description

    Colistin is an orally active polypeptide antibiotic. Colistin has excellent activity against various Gram-negative rod-shaped bacteria, including multidrug-resistant Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae. Colistin is associated with nephrotoxicity. Colistin can be used for the research of infections caused by Gram-negative bacilli[1][2].

    In Vivo

    Colistin (16 mg/kg/day, i.p.) shows the enrichment of cell cycle arrest genes and suggests that injury or cellular stress caused by colistin is acting through p53 to inhibit cell cycle progression[1].
    Colistin (16 mg/kg/day, i.p.) has elevated blood urea nitrogen (BUN), creatinine, and pathologic evidence of acute tubular necrosis and apoptosis[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: C57/BL6 mice[1]
    Dosage: 16 mg/kg/day
    Administration: 16 mg/kg/day, i.p.
    Result: Detected apoptosis, necrosis PCNA staining in mice.
    Clinical Trial
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    [H][C@@]([C@@H](C)O)(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](NC([C@@H](N1)CCN)=O)CC(C)C)=O)CC(C)C)=O)CCN)=O)CCN)=O)C(NCC[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CCC[R])=O)CCN)=O)[C@@H](C)O)=O)CCN)=O)C1=O)=O.[C]C(C)C.[C][C@H](CC)C.[R:].[R:].[Colistin B].[Colistin A]
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    H2O : 100 mg/mL (Need ultrasonic)

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    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 95%

    SDS (393 KB)

    COA (253 KB)

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    Colistin Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Colistin1066-17-7Polymyxin EAntibioticBacterialoralpolypeptide antibioticPseudomonas aeruginosaKlebsiella pneumoniaeAcinetobacter baumanniiGram-negative bacterianephrotoxicityinfectionInhibitorinhibitorinhibit

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