Cyclophilin inhibitor 1

Name: Cyclophilin inhibitor 1
Brand: MedChemExpress
SKU: HY-112712
Rating: 4.5 (0 reviews)

Cat. No.: HY-112712 Pureza: 99.55%: Ficha de datos
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Cyclophilin inhibitor 1 is a potent and orally bioavailable cyclophilin A inhibitor, with a K_d of 5 nM, shows effective anti-HCV activity, with an EC₅₀ of 98 nM for HCV 2a.

Para uso exclusivo en investigación. No vendemos a pacientes.

Cyclophilin inhibitor 1 Estructura química

No. CAS : 1509904-96-4

Tamaño	Stock	Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
1 mg	En stock	Estimated Time of Arrival: December 31
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	Obtener un presupuesto
200 mg	Obtener un presupuesto

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Revisión del cliente

Based on 1 Customer Validation

Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas Cyclophilin:

Ver todas las isoformas

Cyclophilin A Cyclophilin B Cyclophilin C Cyclophilin D Cyclophilin G Cyclophilin E

Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

Cyclophilin inhibitor 1 is a potent and orally bioavailable cyclophilin A inhibitor, with a K_d of 5 nM, shows effective anti-HCV activity, with an EC₅₀ of 98 nM for HCV 2a^[1].

IC₅₀ & Target

Cyclophilin A

Cellular Effect

Cell Line	Type	Value	Description	References
MT4	CC₅₀	> 40000 nM Compound: 3	Cytotoxicity against human MT4 cells assessed as reduction in cell viability after 4 to 5 days by cell-titer glo assay Cytotoxicity against human MT4 cells assessed as reduction in cell viability after 4 to 5 days by cell-titer glo assay	[PMID: 30074795]

In Vitro

Cyclophilin inhibitor 1 (Compound 3) inhibits HCV 2a activity, with an EC₅₀ of 98 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

593.67

Fòrmula

C₃₁H₃₉N₅O₇

No. CAS

1509904-96-4

Appearance

Solid

Color

White to off-white

SMILES

C[C@@H](NC([C@@H]1CCCN(C([C@H](C)NC([C@H](C(C)C)OC2=O)=O)=O)N1)=O)C3=CC=C4C(C=C(/C=C/C52COCOC5)C=C4)=N3

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvente y solubilidad

In Vitro:

DMSO : ≥ 100 mg/mL (168.44 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6844 mL	8.4222 mL	16.8444 mL
5 mM	0.3369 mL	1.6844 mL	3.3689 mL
10 mM	0.1684 mL	0.8422 mL	1.6844 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Pureza y Documentación

Purity: 99.55%

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Ficha de datos (278 KB) SDS (252 KB)

COA (260 KB) HNMR (408 KB) RP-HPLC (266 KB) LCMS (92 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Mackman RL, et al. Discovery of a Potent and Orally Bioavailable Cyclophilin Inhibitor Derived from the Sanglifehrin Macrocycle. J Med Chem. 2018 Nov 8;61(21):9473-9499. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.6844 mL	8.4222 mL	16.8444 mL	42.1109 mL
	5 mM	0.3369 mL	1.6844 mL	3.3689 mL	8.4222 mL
	10 mM	0.1684 mL	0.8422 mL	1.6844 mL	4.2111 mL
	15 mM	0.1123 mL	0.5615 mL	1.1230 mL	2.8074 mL
	20 mM	0.0842 mL	0.4211 mL	0.8422 mL	2.1055 mL
	25 mM	0.0674 mL	0.3369 mL	0.6738 mL	1.6844 mL
	30 mM	0.0561 mL	0.2807 mL	0.5615 mL	1.4037 mL
	40 mM	0.0421 mL	0.2106 mL	0.4211 mL	1.0528 mL
	50 mM	0.0337 mL	0.1684 mL	0.3369 mL	0.8422 mL
	60 mM	0.0281 mL	0.1404 mL	0.2807 mL	0.7018 mL
	80 mM	0.0211 mL	0.1053 mL	0.2106 mL	0.5264 mL
	100 mM	0.0168 mL	0.0842 mL	0.1684 mL	0.4211 mL