D-Glutamic acid (Synonyms: (R)-Glutamic acid)

Name: D-Glutamic acid
Brand: MedChemExpress
SKU: HY-100805
Rating: 4.5 (1 reviews)

Cat. No.: HY-100805 Purity: 98.0%: Data Sheet
COA

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Handling Instructions
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D-glutamic acid, an enantiomer of L- glutamic acid, is widely used in pharmaceuticals and foods.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

D-Glutamic acid 화학구조

CAS No. : 6893-26-1

사이즈	재고	수량
1 g	해외재고보유	Estimated Time of Arrival: December 31
5 g	해외재고보유	Estimated Time of Arrival: December 31
10 g	해외재고보유	Estimated Time of Arrival: December 31
25 g	해외재고보유	Estimated Time of Arrival: December 31
50 g	해외재고보유	Estimated Time of Arrival: December 31
100 g	해외재고보유	Estimated Time of Arrival: December 31
> 100 g	견적 받기

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This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 publication(s) in Google Scholar

Other Forms of D-Glutamic acid:

1 Publications Citing Use of MCE D-Glutamic acid

•Molecules. 2023 Apr 11;28(8):3375.

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•Related Screening Libraries:

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View All Endogenous Metabolite Isoform Specific Products:

View All Isoforms

Human Endogenous Metabolite Microbial Metabolite

Biological Activity
Protocol
순도&문서
References
고객리뷰

제품 설명

D-glutamic acid, an enantiomer of L- glutamic acid, is widely used in pharmaceuticals and foods.

IC₅₀ & Target

Microbial Metabolite

Human Endogenous Metabolite

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	> 1000 μM Compound: (R)-glu	Agonistic activity at mGlu1-alpha receptor expressed in CHO cells Agonistic activity at mGlu1-alpha receptor expressed in CHO cells	[PMID: 8759641]
CHO	EC₅₀	> 1000 μM Compound: (R)-glu	Agonistic activity at mGlu2 receptor expressed in CHO cells Agonistic activity at mGlu2 receptor expressed in CHO cells	[PMID: 8759641]
CHO	EC₅₀	> 1000 μM Compound: (R)-glu	Agonistic activity at mGlu6 receptor expressed in CHO cells Agonistic activity at mGlu6 receptor expressed in CHO cells	[PMID: 8759641]
HEK293	EC₅₀	< 100 μM Compound: 1	Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Active Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Active	[PMID: 15801843]
HEK293	EC₅₀	> 1000 μM Compound: D-glu	Inhibition of the Excitatory Amino Acid Transporter 1 (EAAT1, SLC1A3) as assessed by a phenotypic impedance-based assay detecting changes in cell morphology by L-glutamate uptake in HEK-293 JumpIN-SLC1A3 cells (PubChem AID: 1745862) Inhibition of the Excitatory Amino Acid Transporter 1 (EAAT1, SLC1A3) as assessed by a phenotypic impedance-based assay detecting changes in cell morphology by L-glutamate uptake in HEK-293 JumpIN-SLC1A3 cells (PubChem AID: 1745862)	[PMID: 35677430]
THP-1	ED₅₀	> 100000 nM Compound: (R)-glutamic acid	In vitro activity to inhibit MCP-1-induced leukocyte migration of THP-1 cells In vitro activity to inhibit MCP-1-induced leukocyte migration of THP-1 cells	[PMID: 15689171]

In Vitro

Various d-amino acids, such as D-serine, D-aspartic acid (D-Asp), and D-glutamic acid (D-Glu) are widely found in mammals including human beings and they are now thought to be the candidates of novel physiologically active substances and/or biomarkers^[1]. D-[Asp/Glu] (4 mg/mL) inhibits IgE binding (75%) to peanuts while D-Glu, D-Asp has no inhibitory effect. IgE is specific for D-[Asp/Glu] and may have the potential for removing IgE or reducing IgE binding to peanut allergens^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

D-glutamic acid is currently paid attention as a modulator of neuronal transmission and hormonal secretion. It is metabolized only by D-aspartate oxidase in mammals^[1]. After intraperitoneal injection, L-glutamate is catabolized via a-ketoglutarate, whereas D-glutamate is converted to n-pyrrolidone carboxylic acid. Carbon 2 of both D- and L-glutamate is converted in the cecum to the methyl carbon of acetate. Both rat liver and kidney catalyze the conversion of D-glutamic acid to n-pyrrolidone carboxylic acid^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

147.13

화학식

C₅H₉NO₄

CAS No.

6893-26-1

Appearance

Solid

Color

White to off-white

SMILES

N[C@H](CCC(O)=O)C(O)=O

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Microorganisms

Escherichia coli

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

용액&용해도

In Vitro:

1 M NaOH : 50 mg/mL (339.84 mM; Need ultrasonic)

H₂O : 13 mg/mL (88.36 mM; ultrasonic and adjust pH to 3 with NaOH)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.7967 mL	33.9836 mL	67.9671 mL
5 mM	1.3593 mL	6.7967 mL	13.5934 mL
10 mM	0.6797 mL	3.3984 mL	6.7967 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 10 mg/mL (67.97 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

순도&문서

Purity: ≥99.0%

Select Batch:

Data Sheet (273 KB) SDS (393 KB)

COA (305 KB)

Handling Instructions (2659 KB)

References

[1]. Han H, et al. Changes in D-aspartic acid and D-glutamic acid levels in the tissues and physiological fluids of mice with various D-aspartate oxidase activities. J Pharm Biomed Anal. 2015 Dec 10;116:47-52. [Content Brief]

[2]. Chung SY, et al. IgE binding to peanut allergens is inhibited by combined D-aspartic and D-glutamic acids. Food Chem. 2015 Jan 1;166:248-53. [Content Brief]

[3]. Wilson W, et al. The metabolism of D- and L- glutamic acid in the rat. J Biol Chem. 1961 Feb;236:365-9. [Content Brief]

Animal Administration
^[3]

Rats: Male albino rats are given injections of L- or D-glutamic acid-2-C¹⁴, DL-glutamic acid-5-C¹⁴, or D-glutamic acid-5-C¹⁴. Injections by stomach tube or into the cecum are performed while the animals are under ether anesthesia. After the rats are killed, the “carcass” and liver glutamic acids are isolated, degraded, and assayed for radioactivity. “Carcass” refers to the entire animal, except liver, including the ished gastrointestinal tract^[3].

MCE 는 독립적으로 이러한 방법들의 정확성을 확인하지 않았습니다. 참고용으로만 봐주십시오.

References

[1]. Han H, et al. Changes in D-aspartic acid and D-glutamic acid levels in the tissues and physiological fluids of mice with various D-aspartate oxidase activities. J Pharm Biomed Anal. 2015 Dec 10;116:47-52. [Content Brief]

[2]. Chung SY, et al. IgE binding to peanut allergens is inhibited by combined D-aspartic and D-glutamic acids. Food Chem. 2015 Jan 1;166:248-53. [Content Brief]

[3]. Wilson W, et al. The metabolism of D- and L- glutamic acid in the rat. J Biol Chem. 1961 Feb;236:365-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / 1 M NaOH	1 mM	6.7967 mL	33.9836 mL	67.9671 mL	169.9178 mL
	5 mM	1.3593 mL	6.7967 mL	13.5934 mL	33.9836 mL
	10 mM	0.6797 mL	3.3984 mL	6.7967 mL	16.9918 mL
	15 mM	0.4531 mL	2.2656 mL	4.5311 mL	11.3279 mL
	20 mM	0.3398 mL	1.6992 mL	3.3984 mL	8.4959 mL
	25 mM	0.2719 mL	1.3593 mL	2.7187 mL	6.7967 mL
	30 mM	0.2266 mL	1.1328 mL	2.2656 mL	5.6639 mL
	40 mM	0.1699 mL	0.8496 mL	1.6992 mL	4.2479 mL
	50 mM	0.1359 mL	0.6797 mL	1.3593 mL	3.3984 mL
	60 mM	0.1133 mL	0.5664 mL	1.1328 mL	2.8320 mL
	80 mM	0.0850 mL	0.4248 mL	0.8496 mL	2.1240 mL
1 M NaOH	100 mM	0.0680 mL	0.3398 mL	0.6797 mL	1.6992 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

D-Glutamic acid Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

D-Glutamic acid6893-26-1(R)-Glutamic acidEndogenous MetaboliteInhibitorinhibitorinhibit

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D-Glutamic acid (Synonyms: (R)-Glutamic acid)

고객리뷰

Other Forms of D-Glutamic acid:

D-Glutamic acid Related Antibodies

1 Publications Citing Use of MCE D-Glutamic acid

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Endogenous Metabolite Isoform Specific Products:

Biological Activity

Protocol

순도&문서

References

고객리뷰

D-Glutamic acid Related Antibodies

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

D-Glutamic acid Related Classifications

Keywords:

최근 본 상품:

고객리뷰

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SAFETY DATA SHEET (SDS)

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