2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. Deltorphin I

Deltorphin I  (Synonyms: Deltorphin 1; Deltorphin C; [D-Ala2] Deltorphin I)

Cat. No.: HY-P1336 Pureza: 96.69%
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Deltorphin I is a δ-opioid receptor agonist with high affinity and selectivity.

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Deltorphin I

Deltorphin I Estructura química

No. CAS : 122752-15-2

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5 mg En stock
10 mg En stock
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100 mg   Obtener un presupuesto  

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Other Forms of Deltorphin I:

Deltorphin I Related Antibodies

Top Publications Citing Use of Products

Ver todos los productos específicos de isoformas Opioid Receptor:

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μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

  • Actividad biológica

  • Protocolo

  • Pureza y Documentación

  • Referencias

  • Revisión del cliente

Descripciòn

Deltorphin I is a δ-opioid receptor agonist with high affinity and selectivity.

IC50 & Target

δ Opioid Receptor/DOR

 

Cellular Effect
Cell Line Type Value Description References
CHO EC50
<0.01 1
Compound: Deltorphin-2
Activity at delta opioid receptor assessed as increase in calcium level in CHO cells by aequorin luminescence based calcium assay
Activity at delta opioid receptor assessed as increase in calcium level in CHO cells by aequorin luminescence based calcium assay
[PMID: 17266203]
CHO EC50
< 0.01 1
Compound: deltorphin-II
Antagonist activity at delta opioid receptor expressed in CHO cells assessed as release of intracellular calcium ions by aequorin luminescence-based calcium assay
Antagonist activity at delta opioid receptor expressed in CHO cells assessed as release of intracellular calcium ions by aequorin luminescence-based calcium assay
[PMID: 18207400]
CHO EC50
< 0.01 1
Compound: Deltorphin-2
Activity at delta opioid receptor assessed as increase in calcium level in CHO cells by aequorin luminescence based calcium assay
Activity at delta opioid receptor assessed as increase in calcium level in CHO cells by aequorin luminescence based calcium assay
[PMID: 17266203]
CHO EC50
<0.01 1
Compound: deltorphin-II
Antagonist activity at delta opioid receptor expressed in CHO cells assessed as release of intracellular calcium ions by aequorin luminescence-based calcium assay
Antagonist activity at delta opioid receptor expressed in CHO cells assessed as release of intracellular calcium ions by aequorin luminescence-based calcium assay
[PMID: 18207400]
CHO EC50
< 0.01 1
Compound: Deltorphin-2
Activity at delta opioid receptor assessed as increase in calcium level in CHO cells by aequorin luminescence based calcium assay
Activity at delta opioid receptor assessed as increase in calcium level in CHO cells by aequorin luminescence based calcium assay
[PMID: 17266203]
CHO EC50
< 0.01 1
Compound: deltorphin-II
Antagonist activity at delta opioid receptor expressed in CHO cells assessed as release of intracellular calcium ions by aequorin luminescence-based calcium assay
Antagonist activity at delta opioid receptor expressed in CHO cells assessed as release of intracellular calcium ions by aequorin luminescence-based calcium assay
[PMID: 18207400]
In Vivo

Twice daily administration of Deltorphin I (20μg/mouse) for 4 days produces tolerance to Deltorphin I analgesia, as shown by the decrease in the analgesic response. The peak analgesic response to Deltorphin I (20 μg/mouse) at 10 min after injections is decreased from 8.36±0.28 s (the 1st day) to 4.53±0.14 s (the 4th day) markedly. Concurrent treatment of Melatonin (0.5, 1 and 2.5 mg/kg) and Deltorphin I (20 μg/mouse) twice daily for 4 days can attenuate the tolerance to Deltorphin I analgesia (P<0.05, <0.05 and <0.05), and this effect is dose dependent[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Peso molecular

768.86

Fòrmula

C37H52N8O10
No. CAS
Appearance

Solid

Color

White to off-white

Sequence

Tyr-{d-Ala}-Phe-Asp-Val-Val-Gly-NH2
Sequence Shortening

Y-{d-Ala}-FDVVG-NH2
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvente y solubilidad
In Vitro: 

DMSO : 25 mg/mL (32.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3006 mL 6.5031 mL 13.0063 mL
5 mM 0.2601 mL 1.3006 mL 2.6013 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación
Referencias
Administraciòn de animales
[1]

Mice[1]
Male Kunming mice (20.0±1.0 g) are used. In order to investigate the chronic effect of Melatonin on opioid receptor agonist analgesia, 18, 17, 16 and 21 mice are treated with Melatonin (0, 0.5, 1 and 2.5 mg/kg, respectively) twice daily for 4 days. On the 5th day, 8, 8, 8 and 9 mice are administered with Endomorphin-1 18 μg/mouse (corresponding to 0, 0.5, 1 and 2.5 mg/kg Melatonin, respectively), while 10, 9, 8 and 12 mice are administered with Deltorphin I 20 μg/mouse (corresponding to 0, 0.5, 1 and 2.5 mg/kg Melatonin, respectively). Subsequently tail-flick latency is measured at 10 min interval within 60 min[1].

MCE no ha confirmado la precisión de estos métodos independientemente. Son solo para referencia.
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3006 mL 6.5031 mL 13.0063 mL 32.5157 mL
5 mM 0.2601 mL 1.3006 mL 2.6013 mL 6.5031 mL
10 mM 0.1301 mL 0.6503 mL 1.3006 mL 3.2516 mL
15 mM 0.0867 mL 0.4335 mL 0.8671 mL 2.1677 mL
20 mM 0.0650 mL 0.3252 mL 0.6503 mL 1.6258 mL
25 mM 0.0520 mL 0.2601 mL 0.5203 mL 1.3006 mL
30 mM 0.0434 mL 0.2168 mL 0.4335 mL 1.0839 mL
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Deltorphin I Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Deltorphin I122752-15-2Deltorphin 1 Deltorphin C [D-Ala2] Deltorphin IDeltorphin1Deltorphin-1Opioid ReceptorInhibitorinhibitorinhibit

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Nombre del producto:
Deltorphin I
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HY-P1336
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