2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. Deltorphin I TFA

Deltorphin I TFA  (Synonyms: Deltorphin 1 TFA; Deltorphin C TFA; [D-Ala2] Deltorphin I TFA)

Cat. No.: HY-P1336A
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Deltorphin I TFA (Deltorphin 1 TFA; Deltorphin C TFA; [D-Ala2] Deltorphin I TFA) is a high-affinity, selective δ-opioid receptor agonist that targets the δ1 and δ2 opioid receptor subtypes. Deltorphin I TFA produces analgesic effects in the rat spinal cord. Deltorphin I TFA increases the pain threshold in rats. Deltorphin I TFA can be used in studies related to nociception (acute pain).

For research use only. We do not sell to patients.

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Deltorphin I TFA

Deltorphin I TFA Chemical Structure

CAS No. : 2952824-50-7

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Deltorphin I TFA Related Antibodies

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Description

Deltorphin I TFA (Deltorphin 1 TFA; Deltorphin C TFA; [D-Ala2] Deltorphin I TFA) is a high-affinity, selective δ-opioid receptor agonist that targets the δ1 and δ2 opioid receptor subtypes. Deltorphin I TFA produces analgesic effects in the rat spinal cord. Deltorphin I TFA increases the pain threshold in rats. Deltorphin I TFA can be used in studies related to nociception (acute pain)[1].

IC50 & Target[1]

δ Opioid Receptor/DOR

 

In Vivo

Deltorphin I (0.15-15 μg; intrathecal injection; single administration) TFA exerts dose-dependent analgesic effects in acute nociception tests in rats by activating δ1 and δ2 opioid receptors[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats (male, 260-350 g, intrathecal lumbar enlargement catheter implantation)[1]
Dosage: 0.15 μg; 1.5 μg; 15 μg
Administration: i.th.; single injection
Result: Significantly increased tail-flick latency in a dose-dependent manner, with effects starting at 15 minutes post-injection and lasting for 120 minutes.
Reached maximum effect at 15 minutes for all doses, with duration of effect increasing with higher doses.
Significantly increased paw pressure threshold at 1.5 μg and 15 μg doses starting at 15 minutes post-injection; showed no effect at 0.15 μg dose.
Had its antinociceptive effect significantly antagonized by coadministration of 30 μg NTI, 3 μg NTB, or 1 μg BNTX in both tail-flick and paw pressure tests.
Had its effect completely blocked by NTI in the paw pressure test.
Molecular Weight

882.88

Formula

C39H53F3N8O12
CAS No.
Sequence

Tyr-Ala-Phe-Asp-Val-Val-Gly
Sequence Shortening

YAFDVVG
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Deltorphin I TFA Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Deltorphin I2952824-50-7Deltorphin 1Deltorphin C[D-Ala2] Deltorphin IDeltorphin1Deltorphin-1Opioid Receptornociceptive thresholdrat spinal cordrat paw pressure testδ opioid receptorantinociceptive effectsnociceptionacute painδ2 opioid receptorrat tail-flick testδ1 opioid receptorInhibitorinhibitorinhibit

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