1. GPCR/G Protein
    Neuronal Signaling
  2. Opioid Receptor

Deltorphin I (Synonyms: Deltorphin 1; Deltorphin C)

Cat. No.: HY-P1336
Handling Instructions

Deltorphin I is a δ-opioid receptor agonist with high affinity and selectivity. Sequence: Tyr-{d-Ala}-Phe-Asp-Val-Val-Gly-NH2;Y-{d-Ala}-FDVVG-NH2.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Deltorphin I Chemical Structure

Deltorphin I Chemical Structure

CAS No. : 122752-15-2

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Deltorphin I is a δ-opioid receptor agonist with high affinity and selectivity. Sequence: Tyr-{d-Ala}-Phe-Asp-Val-Val-Gly-NH2;Y-{d-Ala}-FDVVG-NH2.

IC50 & Target

δ-opioid receptor[1]

In Vivo

Twice daily administration of Deltorphin I (20μg/mouse) for 4 days produces tolerance to Deltorphin I analgesia, as shown by the decrease in the analgesic response. The peak analgesic response to Deltorphin I (20 μg/mouse) at 10 min after injections is decreased from 8.36±0.28 s (the 1st day) to 4.53±0.14 s (the 4th day) markedly. Concurrent treatment of Melatonin (0.5, 1 and 2.5 mg/kg) and Deltorphin I (20 μg/mouse) twice daily for 4 days can attenuate the tolerance to Deltorphin I analgesia (P<0.05, <0.05 and <0.05), and this effect is dose dependent[1].

Solvent & Solubility
In Vitro: 

10 mM in H2O

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3006 mL 6.5031 mL 13.0063 mL
5 mM 0.2601 mL 1.3006 mL 2.6013 mL
10 mM 0.1301 mL 0.6503 mL 1.3006 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[1]

Mice[1]
Male Kunming mice (20.0±1.0 g) are used. In order to investigate the chronic effect of Melatonin on opioid receptor agonist analgesia, 18, 17, 16 and 21 mice are treated with Melatonin (0, 0.5, 1 and 2.5 mg/kg, respectively) twice daily for 4 days. On the 5th day, 8, 8, 8 and 9 mice are administered with Endomorphin-1 18 μg/mouse (corresponding to 0, 0.5, 1 and 2.5 mg/kg Melatonin, respectively), while 10, 9, 8 and 12 mice are administered with Deltorphin I 20 μg/mouse (corresponding to 0, 0.5, 1 and 2.5 mg/kg Melatonin, respectively). Subsequently tail-flick latency is measured at 10 min interval within 60 min[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

768.86

Formula

C₃₇H₅₂N₈O₁₀

CAS No.

122752-15-2

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Deltorphin I
Cat. No.:
HY-P1336
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Deltorphin I

Cat. No.: HY-P1336