2. Metabolic Enzyme/Protease Apoptosis
  3. Endogenous Metabolite Apoptosis
  4. L-Cystathionine

L-Cystathionine  (Synonyms: L-シスタチオニン)

製品番号: HY-W009749 純度: 99.0%
COA 取扱説明書 Technical Support

L-Cystathionine is a nonprotein thioether and is a key amino acid associated with the metabolic state of sulfur-containing amino acids. L-Cystathionine protects against Homocysteine-induced mitochondria-dependent apoptosis of vascular endothelial cells (HUVECs). L-Cystathionine plays an important role in cardiovascular protection.

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L-Cystathionine

L-Cystathionine 構造式

CAS 番号 : 56-88-2

容量 価格（税別） 在庫状況 数量
1 mg $50 在庫あり
5 mg $125 在庫あり
10 mg $200 在庫あり
25 mg $400 在庫あり
50 mg $640 在庫あり
100 mg $1025 在庫あり
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500 mg   お問い合わせ  

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Based on 1 publication(s) in Google Scholar

Other Forms of L-Cystathionine:

L-Cystathionine 関連抗体

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製品説明

L-Cystathionine is a nonprotein thioether and is a key amino acid associated with the metabolic state of sulfur-containing amino acids. L-Cystathionine protects against Homocysteine-induced mitochondria-dependent apoptosis of vascular endothelial cells (HUVECs). L-Cystathionine plays an important role in cardiovascular protection[1][2].

IC50 & Target[1]

Human Endogenous Metabolite

 

体外実験

Homocysteine obviously induces the apoptosis of HUVECs, and this effect is significantly attenuated by the pretreatment with L-cystathionine. Furthermore, L-cystathionine decreases the production of mitochondrial superoxide anion and the expression of Bax and restrained its translocation to mitochondria, increases mitochondrial membrane potential, inhibits mitochondrial permeability transition pore (MPTP) opening, suppresses the leakage of cytochrome c from mitochondria into the cytoplasm, and downregulated activities of caspase-9 and caspase-3[1].
L-Cystathionine is an important metabolic intermediate in the L-cysteine transsulfuration pathway from L-methionine via L-homocysteine in mammalian tissues[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

L-Cystathionine 関連抗体
分子量

222.26

分子式

C7H14N2O4S
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

N[C@@H](CCSC[C@H](N)C(O)=O)C(O)=O
Structure Classification
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
溶剤 & 溶解度
体外: 

1M HCl : 50 mg/mL (224.96 mM; ultrasonic and adjust pH to 1 with HCl)

H2O : 40 mg/mL (179.97 mM; adjust pH to 2 with 1 M HCl)

H2O : 25 mg/mL (112.48 mM; ultrasonic and adjust pH to 10 with NaOH)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4992 mL 22.4962 mL 44.9924 mL
5 mM 0.8998 mL 4.4992 mL 8.9985 mL
10 mM 0.4499 mL 2.2496 mL 4.4992 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 3.33 mg/mL (14.98 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.0%

COA (244 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / H2O / 1M HCl 1 mM 4.4992 mL 22.4962 mL 44.9924 mL 112.4809 mL
5 mM 0.8998 mL 4.4992 mL 8.9985 mL 22.4962 mL
10 mM 0.4499 mL 2.2496 mL 4.4992 mL 11.2481 mL
15 mM 0.2999 mL 1.4997 mL 2.9995 mL 7.4987 mL
20 mM 0.2250 mL 1.1248 mL 2.2496 mL 5.6240 mL
25 mM 0.1800 mL 0.8998 mL 1.7997 mL 4.4992 mL
30 mM 0.1500 mL 0.7499 mL 1.4997 mL 3.7494 mL
40 mM 0.1125 mL 0.5624 mL 1.1248 mL 2.8120 mL
50 mM 0.0900 mL 0.4499 mL 0.8998 mL 2.2496 mL
60 mM 0.0750 mL 0.3749 mL 0.7499 mL 1.8747 mL
80 mM 0.0562 mL 0.2812 mL 0.5624 mL 1.4060 mL
100 mM 0.0450 mL 0.2250 mL 0.4499 mL 1.1248 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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L-Cystathionine Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Cystathionine56-88-2Endogenous MetaboliteApoptosisaminoacidsulfur-containingHomocysteineapoptosisvascularendothelialcellscardiovascularHUVECsInhibitorinhibitorinhibit

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製品名:
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製品番号:
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