2. Search Result
Search Result
Results for "

L69

" in MedChemExpress (MCE) Product Catalog:

24

Inhibitors & Agonists

1

Click Chemistry

Cat. No. 상품명 Target 연구분야 Chemical Structure
  • HY-75957
    DMP 777
    5 Publications Verification

    L-694458

    		 Elastase Inflammation/Immunology
    DMP 777 is a potent, selective, and orally active human leukocyte elastase (HLE) inhibitor.
    DMP 777
  • HY-101075
    L-690330
    1 Publications Verification

    		 Phosphatase Others
    L-690330 is a competitive inhibitor of inositol monophosphatase (IMPase) with Kis of 0.27 and 0.19 μM for recombinant human and bovine IMPase, 0.30 and 0.42 μM for human and bovine frontal cortex IMPase, respectively. L-690330 exhibits 10-fold more sensitive than mouse and rat IMPase .
    L-690330
  • HY-50760
    L-692585

    		GHSR Endocrinology
    L-692585 is a potent and nonpeptidyl growth hormone secretagogue receptor (GHS-R1a) agonist, with a Ki of 0.8 nM. L-692585 acts directly on somatotropes causing GH release .
    L-692585
  • HY-10957
    L-692429

    MK-0751

    		 GHSR Metabolic Disease
    L-692429 (MK-0751) is a benzolactam derivative and a nonpeptidyl growth hormone secretagogue (GHS) agonist. L-692429 binds to G protein-coupled receptor with a Ki of 63 nM .
    L-692429
  • HY-101208
    L-694247

    		5-HT Receptor Neurological Disease Inflammation/Immunology
    L-694247 is a selective 5-HT1D agonist with the pIC50 values of 10.03, 8.64, 6.42, and 5.66 for 5-HT1D, 5-HT1A, 5-HT1C, and 5-HT1E receptors , respectively .
    L-694247
  • HY-101208A
    L-694247 TFA

    		5-HT Receptor Neurological Disease Inflammation/Immunology
    L694247 (TFA) is a selective 5-HT1D agonist with pIC50 values of 10.03, 8.64, 6.42, and 5.66 for 5-HT1D, 5-HT1A, 5-HT1C, and 5-HT1E receptors, respectively .
    L-694247 TFA
  • HY-118979
    L-691678

    		Leukotriene Receptor Inflammation/Immunology
    L-691678 can bind to FLAP by recognizing the amino acid residues of 5-lipoxygenase-activating protein (FLAP), thereby inhibiting leukotriene biosynthesis. L-691678 can be used in the study of leukotriene-related diseases such as allergies, asthma, and inflammation .
    L-691678
  • HY-19213
    L-693612

    		Carbonic Anhydrase Inflammation/Immunology
    L-693612 (Compd 1) is an orally active and topical carbonic anhydrase inhibitor .
    L-693612
  • HY-19141
    L-691121

    		Potassium Channel Cardiovascular Disease
    L-691121 exhibits antiarrhythmic efficacy through block of potassium channel and a followed prolonged cardiac potential. L-691121 exhibits embryotoxicity with fetal mortality at the dose of 0.8 mg/kg/day (p.o.). L-691121 is orally active .
    L-691121
  • HY-129716
    L-693989

    		Bacterial Parasite Infection Inflammation/Immunology
    L-693989 is an orally active water-soluble lipopeptide with anticandidal and antipneumocystis activity. L-693989 is effective in preventing the development of both P. carinii cysts. L-693989 is promising for research of P. carinii pneumonia .
    L-693989
  • HY-101076
    L-690488

    		Phosphatase Metabolic Disease
    L-690488 is a proagent of L-690330 and is a selective inositol monophosphatase (IMPase) inhibitor. L-690488 has more effective cell penetration than L-690330 .
    L-690488
  • HY-19143
    L-697639

    		HIV Infection
    L-697639 is an inhibitor for HIV-1 reverse transcriptase (HIV-1 RT) with IC50 of 20-400 nM (in a template-primer-dependent manner). L-697639 exhibits antiviral activity, that inhibits 95% HIV-1 infection at concentrations of 12-200 nM in human T lymphocyte cultures .
    L-697639
  • HY-105426
    L-695499

    		Leukotriene Receptor Inflammation/Immunology
    L-695499 is a potent and orally active leukotriene D4 receptor antagonist. L-695499 can be used for the researches of inflammation and immunology .
    L-695499
  • HY-120760
    L-691831

    		Lipoxygenase Others
    L-691831 is a ligand for 5-lipoxygenase activating protein binding assays that has utility as a tool for studying 5-lipoxygenase activating protein (FLAP) related activities. L-691831 can be used to measure the affinity of FLAP on the leukocyte membrane for leukotriene synthesis inhibitors, with binding being correlated with inhibition of leukotriene synthesis.
    L-691831
  • HY-118156
    L-699333

    		Others Others
    L-699333 is a 5-lipoxygenase (5-LO) inhibitor belonging to the thieno[2,3,4-cd]indole class. This compound has a 2-ethoxybutyric acid side chain and is a potent inhibitor of the biosynthesis of 5-HPETE and LTB4 produced from human 5-LO, with ICm values of 22 nM, 7 nM, and 3.8 pM for human neutrophils and whole blood, respectively. L-699333 has shown anti-inflammatory and antiasthmatic effects in a variety of animal models, including rat pleurisy models, antigen-induced wheezing models, and awake macaque and sheep asthma models. Its inhibition of 5-LO is highly selective, with higher ICm values or stronger competitive inhibition in FLAP binding assays compared to inhibition of human 15-LO, porcine 12-LO, and ram epididymal cyclooxygenase. The racemic enantiomer 14g of L-699333 is the most potent enantiomer to date, with inhibitory effects similar to those of the known MK-0591, which has been shown in clinical trials to inhibit the biochemical effects of LTB4 biosynthesis in vitro and LTE4 excretion in urine.
    L-699333
  • HY-101075A
    L-690330 hydrate
    1 Publications Verification

    		 Phosphatase Others
    L-690330 hydrate is a competitive inhibitor of inositol monophosphatase (IMPase) with Kis of 0.27 and 0.19 μM for recombinant human and bovine IMPase, 0.30 and 0.42 μM for human and bovine frontal cortex IMPase, respectively. L-690330 hydrate exhibits 10-fold more sensitive than mouse and rat IMPase .
    L-690330 hydrate
  • HY-19213A
    L-693612 hydrochloride

    		Carbonic Anhydrase Inflammation/Immunology
    L-693612 hydrochloride (Compd 1) is an orally active and topical carbonic anhydrase inhibitor .
    L-693612 hydrochloride
  • HY-100930
    L-693403 maleate

    		Sigma Receptor Neurological Disease
    L-693403 maleate is a high affinity and selective σ ligand. L-693403 maleate has the potential for physiological disease research .
    L-693403 maleate
  • HY-10957A
    L-692429 hydrochloride

    MK-0751 hydrochloride

    		 GHSR Metabolic Disease
    L-692429 (MK-0751) hydrochloride is a benzolactam derivative and a nonpeptidyl growth hormone secretagogue (GHS) agonist. L-692429 hydrochloride binds to G protein-coupled receptor with a Ki of 63 nM .
    L-692429 hydrochloride
  • HY-105207
    L 696229

    		HIV Infection
    L 696229 is a specific inhibitor ofhuman immunodeficiency virus type 1 (HIV-1)reverse transcriptase (RT) activity that possesses antiviral activity .
    L 696229
  • HY-120390
    L 694746

    		HIV Protease HIV Infection
    L 694746 is the metabolite of L-689502 (HY-U00261). L 694746 is an inhibitor for HIV-1 protease with an IC50 of 1 nM and a Ki of 0.34 nM .
    L 694746
  • HY-105216
    L 697661

    		Reverse Transcriptase HIV Infection
    L 697661 is an orally active HIV-1 reverse transcriptase inhibitor .
    L 697661
  • HY-117973
    L 691816

    		Lipoxygenase Inflammation/Immunology
    L 691816 is a potent, selective and orally active inhibitors of 5-lipoxygenase. L 691816 can be used for the research of allergies and asthma .
    L 691816
  • HY-180335
    L 691121 free base

    		Drug Metabolite Cardiovascular Disease
    L 691121 (free base) is the major metabolite of L 691121 in plasma. L 691121 (free base) is a class IIIantiarrhythmic agent that blocks potassium currents .
    L 691121 free base

온라인 문의

Your information is safe with us. * Required Fields.

호칭

  

Country or Region *

고객명 *

 

회사명 *

Department *

     

메일주소 *

 

상품명 *

Cat. No.

  

Requested quantity *

전화번호 *

     

비고

온라인 문의

Inquiry Information

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent: