1. GPCR/G Protein
  2. GHSR
  3. L-692585

L-692585 

Cat. No.: HY-50760
Handling Instructions

L-692585 is a potent and nonpeptidyl growth hormone secretagogue receptor (GHS-R1a) agonist, with a Ki of 0.8 nM. L-692585 acts directly on somatotropes causing GH release.

For research use only. We do not sell to patients.

L-692585 Chemical Structure

L-692585 Chemical Structure

CAS No. : 145455-35-2

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Description

L-692585 is a potent and nonpeptidyl growth hormone secretagogue receptor (GHS-R1a) agonist, with a Ki of 0.8 nM. L-692585 acts directly on somatotropes causing GH release[1][2].

IC50 & Target

Ki: 0.8 nM (GHS-R1a)[1]

In Vitro

L-692585 (10 µM; 2 min) produces a prompt transient increase in [Ca2+]i, following by the sustained decline to a plateau above the basal level in GH cells[2].
L-692585 (0.01-10 µM; 2 min) induces release of growth hormone (GH) in a dose-dependent manner from isolated porcine somatotropes[2].
L-692585 (100 nM) significantly increases the number and size of plaques, and it also causes a significant increase in total secretion index (TSI) [2].

In Vivo

L-692585 (0.01-0.1 mg/kg; i.v. once daily for 2 weeks) increases peak plasma GH levels and total GH release[3].
L-692585 (0.005-0.1 mg/kg; a single i.v.) significantly increases peak GH concentrations 4.3-fold at a dose of 0.005 mg/kg, 7-fold at a dose of 0.02 mg/kg, and 21-fold at a dose of 0.10 mg/kg in vivo[3].

Animal Model: Beagles (1-1.5 years old ; weighting 8.5-16.0 kg)[3]
Dosage: 0.01, 0.1 mg/kg
Administration: I.v. once daily for 2 weeks
Result: Increased the peak plasma GH levels and total GH release on days 1, 8 and 15 in a dose-dependent manner, and no desensitization was evident.
Molecular Weight

567.68

Formula

C₃₂H₃₇N₇O₃

CAS No.

145455-35-2

SMILES

CC(C)(NC[[email protected]](O)C)CC(N[[email protected]]1C(N(CC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2)C5=CC=CC=C5CC1)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

L-692585L692585L 692585GHSRGrowth hormone secretagogue receptorgrowthhormonesecretagogueGHS-R1asomatotropesGHInhibitorinhibitorinhibit

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L-692585
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HY-50760
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