L-690330
Based on 1 publication(s) in Google Scholar
L-690330 is a competitive inhibitor of inositol monophosphatase (IMPase) with Kis of 0.27 and 0.19 μM for recombinant human and bovine IMPase, 0.30 and 0.42 μM for human and bovine frontal cortex IMPase, respectively. L-690330 exhibits 10-fold more sensitive than mouse and rat IMPase.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.70%
- CAS 番号: 142523-38-4
- 分子式: C8H12O8P2
- 分子量:298.12
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Anti-Infection Compound Library
HY-L002
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Metabolism/Protease Compound Library
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Phosphatase Inhibitor Library
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HY-L146
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MedChemExpress（MCE）の使用を引用している文献 L-690330
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生物活性
Ki: 0.27 μM (Recombinant human IMPase), 0.19 μM (Recombinant bovine IMPase), 0.30 μM (Human frontal cortex IMPase), 0.42 μM (Bovine frontal cortex IMPase)[1]
L-690330 (50 μM; 1 hour) induces P-AMPK and autophagy and increases LC3-I/II and p-AMPK expression in HEK293 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HEK293 cells
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Concentration:50 μM
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Incubation Time:1 hour
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Result:Improved LC3-I/II and p-AMPK protein level.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Eight-week-old male ICR mice[3]
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Dosage:0.1 μmol
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Administration:Intracerebroventricular injection
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Result:Did not effect mice well-being by i.c.v injection.
化学情報
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CAS 番号 142523-38-4
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性状 Solid
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分子量 298.12
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分子式 C8H12O8P2
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Color White to off-white
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SMILES
OC1=CC=C(OC(P(O)(O)=O)(P(O)(O)=O)C)C=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Sci Rep
2025 Dec 29;15(1):44762. PMID: 41461699
溶剤 & 溶解度
H2O : 66.67 mg/mL (223.63 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Atack JR, et al. In vitro and in vivo inhibition of inositol monophosphatase by the bisphosphonate L-690,330. J Neurochem. 1993 Feb;60(2):652-8. [Content Brief]
[2]. Cárdenas C, et al. Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria.Cell. 2010 Jul 23;142(2):270-83. [Content Brief]
[3]. Shtein L, et al. The inositol monophosphatase inhibitor L-690,330 affects pilocarpine-behavior and the forced swim test.Psychopharmacology (Berl). 2013 Jun;227(3):503-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.3544 mL | 16.7718 mL | 33.5435 mL | 83.8589 mL |
| 5 mM | 0.6709 mL | 3.3544 mL | 6.7087 mL | 16.7718 mL | |
| 10 mM | 0.3354 mL | 1.6772 mL | 3.3544 mL | 8.3859 mL | |
| 15 mM | 0.2236 mL | 1.1181 mL | 2.2362 mL | 5.5906 mL | |
| 20 mM | 0.1677 mL | 0.8386 mL | 1.6772 mL | 4.1929 mL | |
| 25 mM | 0.1342 mL | 0.6709 mL | 1.3417 mL | 3.3544 mL | |
| 30 mM | 0.1118 mL | 0.5591 mL | 1.1181 mL | 2.7953 mL | |
| 40 mM | 0.0839 mL | 0.4193 mL | 0.8386 mL | 2.0965 mL | |
| 50 mM | 0.0671 mL | 0.3354 mL | 0.6709 mL | 1.6772 mL | |
| 60 mM | 0.0559 mL | 0.2795 mL | 0.5591 mL | 1.3976 mL | |
| 80 mM | 0.0419 mL | 0.2096 mL | 0.4193 mL | 1.0482 mL | |
| 100 mM | 0.0335 mL | 0.1677 mL | 0.3354 mL | 0.8386 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
L-690330 関連分類
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