2. Metabolic Enzyme/Protease
  3. Phosphatase
  4. L-690330

L-690330 

Cat. No.: HY-101075 Purity: ≥98.0%
COA Handling Instructions

L-690330 is a competitive inhibitor of inositol monophosphatase (IMPase) with Kis of 0.27 and 0.19 μM for recombinant human and bovine IMPase, 0.30 and 0.42 μM for human and bovine frontal cortex IMPase, respectively. L-690330 exhibits 10-fold more sensitive than mouse and rat IMPase.

For research use only. We do not sell to patients.

L-690330 Chemical Structure

L-690330 Chemical Structure

CAS No. : 142523-38-4

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 176 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 176 In-stock
Solid
5 mg USD 160 In-stock
10 mg USD 260 In-stock
25 mg USD 520 In-stock
50 mg USD 830 In-stock
100 mg USD 1350 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of L-690330:

L-690330 Related Antibodies

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  • Biological Activity

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Description

L-690330 is a competitive inhibitor of inositol monophosphatase (IMPase) with Kis of 0.27 and 0.19 μM for recombinant human and bovine IMPase, 0.30 and 0.42 μM for human and bovine frontal cortex IMPase, respectively. L-690330 exhibits 10-fold more sensitive than mouse and rat IMPase[1].

IC50 & Target

Ki: 0.27 μM (Recombinant human IMPase), 0.19 μM (Recombinant bovine IMPase), 0.30 μM (Human frontal cortex IMPase), 0.42 μM (Bovine frontal cortex IMPase)[1]
In Vitro

L-690330 (50 μM; 1 hour) induces P-AMPK and autophagy and increases LC3-I/II and p-AMPK expression in HEK293 cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

L-690330 Related Antibodies

Western Blot Analysis[2]

Cell Line: HEK293 cells
Concentration: 50 μM
Incubation Time: 1 hour
Result: Improved LC3-I/II and p-AMPK protein level.
In Vivo

L-690330 (intracerebroventricular injection; 0.1 μmol) has no effects on their motor activity and coordination in the beam walking, except a reduction in time spent in light in the dark/light test[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eight-week-old male ICR mice[3]
Dosage: 0.1 μmol
Administration: Intracerebroventricular injection
Result: Did not effect mice well-being by i.c.v injection.
Molecular Weight

298.12

Appearance

Solid

Formula

C8H12O8P2
CAS No.
SMILES

OC1=CC=C(OC(P(O)(O)=O)(P(O)(O)=O)C)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 33.33 mg/mL (111.80 mM; Need ultrasonic)

DMSO : 25 mg/mL (83.86 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3544 mL 16.7718 mL 33.5435 mL
5 mM 0.6709 mL 3.3544 mL 6.7087 mL
10 mM 0.3354 mL 1.6772 mL 3.3544 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (335.44 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.39 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (8.39 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.39 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: ≥98.0%

COA (250 KB)

Handling Instructions (2659 KB)
References
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L-690330 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

L-690330142523-38-4L690330L 690330PhosphataseLSDsensitivityimmobilitybehaviorInhibitorinhibitorinhibit

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