1. Metabolic Enzyme/Protease
  2. Phosphatase
  3. L-690488


Cat. No.: HY-101076
Handling Instructions

L-690488 is a prodrug of L-690330 and is a selective inositol monophosphatase (IMPase) inhibitor. L-690488 has more effective cell penetration than L-690330.

For research use only. We do not sell to patients.

L-690488 Chemical Structure

L-690488 Chemical Structure

CAS No. : 142523-14-6

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L-690488 is a prodrug of L-690330 and is a selective inositol monophosphatase (IMPase) inhibitor. L-690488 has more effective cell penetration than L-690330[1][2].

IC50 & Target

Inositol monophosphatase (IMPase)[1][2]

In Vitro

The effects of L-690488 are studied in cholinergically (carbachol)-stimulated rat cortical slices and Chinese hamster ovary cells stably transfected with the human muscarinic m1 receptor (m1 CHO cells). The EC50 values of L-690488 are 3.7 μM and 1.0 μM in rat cortical slices and m1 CHO cells, respectively). The time course and maximum accumulation of [3H] CMP-PA in L-690488-treated m1 CHO cells is similar to lithium but L-690488 is again much more potent (EC50 values of 3.5 μM and 0.52 mM for L-690488 and lithium, respectively)[1].
L-690488 attenuates the carbachol-induced elevation of inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate in m1 CHO cells. That these effects of L-690488 on the phosphatidylinositol (Pl) cycle are indeed due to inositol depletion[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight







Room temperature in continental US; may vary elsewhere.


Please store the product under the recommended conditions in the Certificate of Analysis.

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L-690488L690488L 690488PhosphataseInositolL-690330phosphatidylinositolbisphosphonatetetrapivaloyloxymethylIMPaseCMP-PAcellpenetrationInhibitorinhibitorinhibit

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