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Cat. No.: HY-105216

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L 697661

L 697661 is an orally active HIV-1 reverse transcriptase inhibitor.

For research use only. We do not sell to patients.

CAS No.: 135525-78-9
Formula: C₁₆H₁₅Cl₂N₃O₂
Molecular Weight:352.22

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

L 697661 Chemical Structure

CAS No.: 135525-78-9

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

L 697661 is an orally active HIV-1 reverse transcriptase inhibitor^[1].

All HIV Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
C8166	EC₅₀	0.007 μM Compound: 3	Inhibition of p24 antigen formation in infected C8166-cells Inhibition of p24 antigen formation in infected C8166-cells	[PMID: 7504733]
C8166	EC₅₀	0.007 μM Compound: 3	Inhibition of syncytia formation in infected C8166-cells Inhibition of syncytia formation in infected C8166-cells	[PMID: 7504733]
MT2	CC₅₀	>10 μM Compound: L-697661	Cytotoxic concentration against MT-2 cells Cytotoxic concentration against MT-2 cells	[PMID: 7684450]
MT2	ED₅₀	<0.3 μM Compound: L-697661	Inhibition of HIV-1 IIIB replication in MT2 (human lymphocyte) cells. Inhibition of HIV-1 IIIB replication in MT2 (human lymphocyte) cells.	[PMID: 7684450]
MT2	IC₅₀	0.08 μM Compound: L-697661	Inhibitory concentration which prevents the spread of HIV-1 IIIB infection in MT2 T-lymphoid cells Inhibitory concentration which prevents the spread of HIV-1 IIIB infection in MT2 T-lymphoid cells	[PMID: 7689109]
MT4	EC₅₀	>10 μM Compound: 3	Inhibition of HIV-1 (strain A17)-infected MT-4 cells Inhibition of HIV-1 (strain A17)-infected MT-4 cells	[PMID: 7504733]
MT4	EC₅₀	0.007 μM Compound: 3	Inhibition of reverse transcriptase of HIV-1 (strain RF)-infected MT-4 cells in RPMI 1640 growth medium in MTM assay Inhibition of reverse transcriptase of HIV-1 (strain RF)-infected MT-4 cells in RPMI 1640 growth medium in MTM assay	[PMID: 7504733]
MT4	ED₅₀	>11 μM Compound: L-697661	Antiviral activity was determined against HIV-1 (clone 90) in MT-4 cells infected with HIV-1 IIIB using an XTT assay Antiviral activity was determined against HIV-1 (clone 90) in MT-4 cells infected with HIV-1 IIIB using an XTT assay	[PMID: 9873380]
MT4	ED₅₀	>11 μM Compound: L-697661	Inhibition of mutant type (Cys181) HIV-1 (IIIB) replication in MT-4 cells Inhibition of mutant type (Cys181) HIV-1 (IIIB) replication in MT-4 cells	[PMID: 8863804]
MT4	ED₅₀	0.065 μM Compound: L-697661	Antiviral activity was determined against wild type HIV-1 in MT-4 cells infected with HIV-1 IIIB using an XTT assay Antiviral activity was determined against wild type HIV-1 in MT-4 cells infected with HIV-1 IIIB using an XTT assay	[PMID: 9873380]
MT4	ED₅₀	0.065 μM Compound: L-697661	Tested for the inhibition of wild type HIV-1 (IIIB) replication in MT-4 cells Tested for the inhibition of wild type HIV-1 (IIIB) replication in MT-4 cells	[PMID: 8863804]
MT4	ED₅₀	0.85 μM Compound: L-697661	Antiviral activity was determined against HIV-1 (clone 118) in MT-4 cells infected with HIV-1 IIIB using an XTT assay Antiviral activity was determined against HIV-1 (clone 118) in MT-4 cells infected with HIV-1 IIIB using an XTT assay	[PMID: 9873380]
MT4	ED₅₀	0.85 μM Compound: L-697661	Inhibition of mutant type (Ile100) HIV-1 (IIIB) replication in MT-4 cells Inhibition of mutant type (Ile100) HIV-1 (IIIB) replication in MT-4 cells	[PMID: 8863804]
MT4	IC₅₀	0.0017 μg/mL Compound: L-697661	Antiviral activity against HIV-1 (strain RF) infected MT-4 cells Antiviral activity against HIV-1 (strain RF) infected MT-4 cells	[PMID: 7538590]
MT4	IC₅₀	0.0023 μg/mL Compound: L-697661	Antiviral activity against HIV-1 resistant to 2-(2-Benzoyl-4-chloro-phenyl)-N-[4-(3-dimethylamino-propoxy)-2-methyl-phenyl]-acetamide in MT-4 cells Antiviral activity against HIV-1 resistant to 2-(2-Benzoyl-4-chloro-phenyl)-N-[4-(3-dimethylamino-propoxy)-2-methyl-phenyl]-acetamide in MT-4 cells	[PMID: 7538590]
MT4	IC₅₀	100 μg/mL Compound: L-697661	Cytotoxicity against uninfected MT-4 cells Cytotoxicity against uninfected MT-4 cells	[PMID: 7538590]
PBMC	CC₅₀	>10 μM Compound: L-697661	Cytotoxic concentration against PBMC cells Cytotoxic concentration against PBMC cells	[PMID: 7684450]

Chemical Information

CAS No. 135525-78-9
Molecular Weight 352.22
Formula C₁₆H₁₅Cl₂N₃O₂
SMILES

O=C1NC(C)=C(CC)C=C1NCC2=NC3=C(O2)C(Cl)=CC=C3Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Saag MS, et al. A short-term clinical evaluation of L-697,661, a non-nucleoside inhibitor of HIV-1 reverse transcriptase. L-697,661 Working Group. N Engl J Med. 1993 Oct 7;329(15):1065-72. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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L 697661

All HIV Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

L 697661 Related Classifications

HY-105216 Related Classifications