Larazotide acetate

Name: Larazotide acetate
Brand: MedChemExpress
SKU: HY-106268A
Rating: 5.0 (4 reviews)

Art. -Nr.: HY-106268A Reinheit: 99.24%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Larazotide acetate is a peptide which is an orally active zonulin antagonist. Larazotide acetate shows antiviral activity to varicella-zoster virus (VZV) with EC₅₀s of 44.14 and 59.06 μM for strain OKA and 07-1, respectively. Larazotide acetate can be used for the research of celiac disease and infection.

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Kundenspezifische Peptidsynthese

Larazotide acetate Chemische Struktur

CAS. Nr. : 881851-50-9

Größe	Verfügbarkeit	Menge
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	Auf Lager	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	Auf Lager	Estimated Time of Arrival: December 31
Solid
1 mg	Auf Lager	Estimated Time of Arrival: December 31
5 mg	Auf Lager	Estimated Time of Arrival: December 31
10 mg	Auf Lager	Estimated Time of Arrival: December 31
25 mg	Auf Lager	Estimated Time of Arrival: December 31
50 mg	Auf Lager	Estimated Time of Arrival: December 31
100 mg	Auf Lager	Estimated Time of Arrival: December 31
200 mg	Angebot einholen
500 mg	Angebot einholen

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This product is a controlled substance and not for sale in your territory.

Kundenbewertung

Based on 4 publication(s) in Google Scholar

Other Forms of Larazotide acetate:

Larazotide In-stock
Larazotide acetate (Standard) Angebot einholen

4 Publications Citing Use of MCE Larazotide acetate

Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biologische Aktivität
Reinheit & Dokumentation
Verweise
Kundenbewertung

Beschreibung

IC₅₀ & Target

Paracellular permeability^[1]

In Vitro

Larazotide acetate (1-100 μM; 5 d) affects Vero cell growth^[1].
Larazotide acetate (1-100 μM; 3 d) shows antiviral activity to varicella-zoster virus (VZV) with EC₅₀s of 44.14 and 59.06 μM for strain OKA and 07-1, respectively^[1].
Larazotide acetate (1 and 3 mM; 72 h) inhibits cytokine-induced tight junction permeability in Caco-2 cells^[2].
Larazotide acetate (12.5 mM; 1 h) inhibits PTG-induced ZO-1 redistribution and actin cytoskeletal rearrangement in IEC6 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:	Vero cell line
Concentration:	1-100 μM
Incubation Time:	5 days
Result:	Inhibited Vero cell growth with an CC₅₀ value of 82.5 μM.

In Vivo

Larazotide acetate (250 μg; i.p. twice a week for 7 weeks) inhibits intestinal permeability in gluten-sensitive transgenic mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	HLA-HCD4/DQ8 double transgenic mice^[2]
Dosage:	250 μg
Administration:	Intraperitoneal injection; 250 μg twice a week for 7 weeks
Result:	Improved barrier function parameters and reduced macrophage counts in the lamina propria to control levels.

Molekulargewicht

785.89

Formel

C₃₄H₅₉N₉O₁₂

CAS. Nr.

881851-50-9

Appearance

Solid

Color

White to off-white

Sequence

Gly-Gly-Val-Leu-Val-Gln-Pro-Gly

Sequence Shortening

GGVLVQPG

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture)

Lösungsmittel & Löslichkeit

In Vitro:

H₂O : 50 mg/mL (63.62 mM; Need ultrasonic)

DMSO : 2 mg/mL (2.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2724 mL	6.3622 mL	12.7244 mL
5 mM	0.2545 mL	1.2724 mL	2.5449 mL
10 mM	0.1272 mL	0.6362 mL	1.2724 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (127.24 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Reinheit & Dokumentation

Purity: 99.68%

Select Batch:

Data Sheet (277 KB) SDS (396 KB)

COA (251 KB) HNMR (227 KB) LCMS (123 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Di Micco S, et al. Peptide Derivatives of the Zonulin Inhibitor Larazotide (AT1001) as Potential Anti SARS-CoV-2: Molecular Modelling, Synthesis and Bioactivity Evaluation. Int J Mol Sci. 2021 Aug 30;22(17):9427. [Content Brief]

[2]. Gopalakrishnan S, et al. Larazotide acetate regulates epithelial tight junctions in vitro and in vivo. Peptides. 2012 May;35(1):86-94. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	1.2724 mL	6.3622 mL	12.7244 mL	31.8111 mL
H₂O	5 mM	0.2545 mL	1.2724 mL	2.5449 mL	6.3622 mL
	10 mM	0.1272 mL	0.6362 mL	1.2724 mL	3.1811 mL
	15 mM	0.0848 mL	0.4241 mL	0.8483 mL	2.1207 mL
	20 mM	0.0636 mL	0.3181 mL	0.6362 mL	1.5906 mL
	25 mM	0.0509 mL	0.2545 mL	0.5090 mL	1.2724 mL
	30 mM	0.0424 mL	0.2121 mL	0.4241 mL	1.0604 mL
	40 mM	0.0318 mL	0.1591 mL	0.3181 mL	0.7953 mL
	50 mM	0.0254 mL	0.1272 mL	0.2545 mL	0.6362 mL
	60 mM	0.0212 mL	0.1060 mL	0.2121 mL	0.5302 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.