Miglustat hydrochloride (Synonyms: N-Butyldeoxynojirimycin hydrochloride; NB-DNJ hydrochloride; OGT 918 hydrochloride)

Name: Miglustat hydrochloride
Brand: MedChemExpress
SKU: HY-17020A
Rating: 5.0 (6 reviews)

Art. -Nr.: HY-17020A Reinheit: 99.97%: Data Sheet
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SDS
Handling Instructions
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Technical Support

Miglustat (N-Butyldeoxynojirimycin) hydrochloride is an orally active and reversible ceramide glucosyltransferase inhibitor, with blood-brain barrier permeability. Miglustat hydrochloride can be used for the research of type I gaucher disease.

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CAS. Nr. : 210110-90-0

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Kostenlose Probe (0.1 - 0.2 mg)	Jetzt bewerben
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	Auf Lager	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	Auf Lager	Estimated Time of Arrival: December 31
Solid
5 mg	Auf Lager	Estimated Time of Arrival: December 31
10 mg	Auf Lager	Estimated Time of Arrival: December 31
25 mg	Auf Lager	Estimated Time of Arrival: December 31
50 mg	Auf Lager	Estimated Time of Arrival: December 31
100 mg	Auf Lager	Estimated Time of Arrival: December 31
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This product is a controlled substance and not for sale in your territory.

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Based on 6 publication(s) in Google Scholar

Other Forms of Miglustat hydrochloride:

Miglustat-d₉ hydrochloride In-stock
Miglustat In-stock
Miglustat hydrochloride (Standard) Angebot einholen

6 Publications Citing Use of MCE Miglustat hydrochloride

In Vivo Imaging

Cell Proliferation/Viability Assay

RT-PCR

Cell Imaging/Staining

: Miglustat hydrochloride purchased from MedChemExpress. Usage Cited in: J Virol. 2025 Mar 18;99(3):e0001825. [Abstract]; Miglustat (5, 10 μM; 24 h) showed no cytotoxicity for Vero cells.

: Miglustat hydrochloride purchased from MedChemExpress. Usage Cited in: J Virol. 2025 Mar 18;99(3):e0001825. [Abstract]; Miglustat (5, 10 μM) decreased the PEDV N mRNA levels in a dose-dependent manner in Vero cells.

: Miglustat hydrochloride purchased from MedChemExpress. Usage Cited in: J Virol. 2025 Mar 18;99(3):e0001825. [Abstract]; Miglustat (5, 10 μM) decreased the PEDV N prodein levels in a dose-dependent manner in Vero cells.

: Miglustat hydrochloride purchased from MedChemExpress. Usage Cited in: J Virol. 2025 Mar 18;99(3):e0001825. [Abstract]; Immunofluorescence assay (IFA) images of Vero cells infected with PEDV and treated with indicated Miglustat (5, 10 μM). Viral N-protein is shown in green, and the nuclei are blue.

: Miglustat hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Aug 14;15(1):6970. [Abstract]; Miglustat combined with anti-PD-1 promotes tumour inhibition. MC38-OVA cells (1 × 105 328 ) were subcutaneously injected into C57BL/6 mice treated with PBS, Miglustat alone (10 mg/kg), anti-PD-1 antibody alone (200 mg/kg per mouse) or Miglustat plus anti-PD-1 as indicated and tumour formation was observed. Tumour sizes were measured every 3 days. The average and individual tumour curves are shown.

: Miglustat hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Rep. 2022 Jul 5;40(1):111049. [Abstract]; Ccin-EGFP-KI male mice were fed by 15 mg/kg Miglustat (NB-DNJ) per day for 5 weeks. NB-DNJ is a drug to disrupt the fusion of the small proacrosomal vesicles into a single acrosome. PNA-FITC-labeled acrosome and EGFP signals were almost lost after NB-DNJ treatment.

: Miglustat hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Rep. 2022 Jul 5;40(1):111049. [Abstract]; Ccin-EGFP-KI male mice were fed by 15 mg/kg Miglustat (NB-DNJ) per day for 5 weeks, the shape of sperm from Ccin-eGFP-KI mice was obviously changed and the acrosome was absent.

: Miglustat hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Rep. 2022 Jul 5;40(1):111049. [Abstract]; Ccin-EGFP-KI male mice were fed by 15 mg/kg Miglustat (NB-DNJ) per day for 5 weeks, The protein levels of Zpbp1 (an acrosomal marker) and eGFP-tagged calicin were significantly reduced.

Spezialitätsempfehlungen

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•Related Small Molecules:

•Related Proteins:

Biologische Aktivität
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Beschreibung

In Vitro

Miglustat (200 μM; 2, 4 and 24 h) hydrochloride restores F508del-CFTR (cystic fibrosis transmembrane conductance regulator) function in cystic fibrosis (CF) bronchial epithelial IB3-1 and CuFi-1 cells. Miglustat hydrochloride reduces the inflammatory response to P. aeruginosa in both CF and non-CF bronchial cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Miglustat (0.2?mg/kg; oral administration; once) hydrochloride is able to rescue synaptic plasticity deficits, to restore ERKs activation and to counteract hyperexcitability^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	NPC1−/− mice^[1]
Dosage:	0.2 mg/kg
Administration:	Oral administration; once
Result:	Was able to rescue synaptic plasticity deficits, to restore ERKs activation and to counteract hyperexcitability.

Molekulargewicht

255.74

Formel

C₁₀H₂₂ClNO₄

CAS. Nr.

210110-90-0

Appearance

Solid

Color

White to light brown

SMILES

O[C@H]1[C@H](O)[C@@H](CO)N(CCCC)C[C@@H]1O.[H]Cl

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 65 mg/mL (254.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : ≥ 34 mg/mL (132.95 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.9102 mL	19.5511 mL	39.1022 mL
5 mM	0.7820 mL	3.9102 mL	7.8204 mL
10 mM	0.3910 mL	1.9551 mL	3.9102 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 3.25 mg/mL (12.71 mM); Clear solution

This protocol yields a clear solution of ≥ 3.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (32.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 3.25 mg/mL (12.71 mM); Clear solution

This protocol yields a clear solution of ≥ 3.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (32.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 3.25 mg/mL (12.71 mM); Clear solution

This protocol yields a clear solution of ≥ 3.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (32.5 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (391.02 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Reinheit & Dokumentation

Purity: 99.97%

Select Batch:

Data Sheet (295 KB) SDS (393 KB)

COA (251 KB) HNMR (273 KB) RP-HPLC (200 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Maria Cristina Dechecchi, et al. Anti-inflammatory effect of miglustat in bronchial epithelial cells. J Cyst Fibros. 2008 Nov;7(6):555-65. [Content Brief]

[2]. G D'Arcangelo, et al. Miglustat Reverts the Impairment of Synaptic Plasticity in a Mouse Model of NPC Disease. Neural Plast. 2016:2016:3830424. [Content Brief]

[3]. Patterson MC, et al. Miglustat for treatment of Niemann-Pick C disease: a randomised controlled study. Lancet Neurol. 2007 Sep;6(9):765-72. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	3.9102 mL	19.5511 mL	39.1022 mL	97.7555 mL
	5 mM	0.7820 mL	3.9102 mL	7.8204 mL	19.5511 mL
	10 mM	0.3910 mL	1.9551 mL	3.9102 mL	9.7756 mL
	15 mM	0.2607 mL	1.3034 mL	2.6068 mL	6.5170 mL
	20 mM	0.1955 mL	0.9776 mL	1.9551 mL	4.8878 mL
	25 mM	0.1564 mL	0.7820 mL	1.5641 mL	3.9102 mL
	30 mM	0.1303 mL	0.6517 mL	1.3034 mL	3.2585 mL
	40 mM	0.0978 mL	0.4888 mL	0.9776 mL	2.4439 mL
	50 mM	0.0782 mL	0.3910 mL	0.7820 mL	1.9551 mL
	60 mM	0.0652 mL	0.3259 mL	0.6517 mL	1.6293 mL
	80 mM	0.0489 mL	0.2444 mL	0.4888 mL	1.2219 mL
	100 mM	0.0391 mL	0.1955 mL	0.3910 mL	0.9776 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Miglustat hydrochloride Related Classifications

Neurological Disease Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Miglustat210110-90-0N-ButyldeoxynojirimycinNB-DNJOGT 918OGT918OGT-918Glucosylceramide Synthase (GCS)oralceramide glucosyltransferasetype I gaucher diseaseInhibitorinhibitorinhibit

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Miglustat hydrochloride (Synonyms: N-Butyldeoxynojirimycin hydrochloride; NB-DNJ hydrochloride; OGT 918 hydrochloride)

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Other Forms of Miglustat hydrochloride:

Miglustat hydrochloride Related Antibodies

6 Publications Citing Use of MCE Miglustat hydrochloride

Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biologische Aktivität

Reinheit & Dokumentation

Verweise

Kundenbewertung

Miglustat hydrochloride Related Antibodies

Molaritätsrechner

Verdünnungsrechner

Complete Stock Solution Preparation Table

Miglustat hydrochloride Related Classifications

Keywords:

Ihre kürzlich angesehenen Produkte:

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