1. Protein Tyrosine Kinase/RTK
    Autophagy
  2. c-Met/HGFR
    Autophagy
  3. PHA-665752

PHA-665752 

Cat. No.: HY-11107 Purity: 96.50%
Handling Instructions

PHA-665752 is a potent, selective and ATP-competitive c-Met inhibitor with an IC50 of 9 nM.

For research use only. We do not sell to patients.

PHA-665752 Chemical Structure

PHA-665752 Chemical Structure

CAS No. : 477575-56-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 108 In-stock
Estimated Time of Arrival: December 31
10 mg USD 98 In-stock
Estimated Time of Arrival: December 31
50 mg USD 396 In-stock
Estimated Time of Arrival: December 31
100 mg USD 696 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Top Publications Citing Use of Products

    PHA-665752 purchased from MCE. Usage Cited in: Oncotarget. 2017 Jun 13;8(24):38717-38730.

    KU812/IR cells are exposed to the indicated concentrations of Imatinib or PHA665752. After incubation for 48 h, the cytoplasmic fractions are extracted and then subjected to SDS-PAGE/immunoblotting with anti-phospho-MET, anti-phospho-ABL1, anti-phospho-ERK1/2, anti-phospho-AKT, anti-phospho-JNK, anti-MET, anti-ABL1, anti-ERK1/2, anti-AKT, and anti-JNK antibodies. Anti-β-ACTIN antibody is used as internal standards.
    • Biological Activity

    • Technical Information

    • Purity & Documentation

    • References

    Description

    PHA-665752 is a potent, selective and ATP-competitive c-Met inhibitor with an IC50 of 9 nM.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 50 mg/mL (77.93 mM; Need ultrasonic)

    H2O : < 0.1 mg/mL (insoluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.5586 mL 7.7929 mL 15.5858 mL
    5 mM 0.3117 mL 1.5586 mL 3.1172 mL
    10 mM 0.1559 mL 0.7793 mL 1.5586 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (3.90 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (3.90 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
    Molecular Weight

    641.61

    Formula

    C₃₂H₃₄Cl₂N₄O₄S

    CAS No.

    477575-56-7

    SMILES

    O=C(C1=C(NC(/C=C2C(NC3=C\2C=C(C=C3)S(=O)(CC4=C(C=CC=C4Cl)Cl)=O)=O)=C1C)C)N5[[email protected]](CCC5)CN6CCCC6

    Shipping

    Room temperature in continental US; may vary elsewhere

    Purity: 96.50%

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product name

     

    Salutation

    Applicant name *

     

    Email address *

    Phone number *

     

    Organization name *

    Country or Region *

     

    Requested quantity *

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    PHA-665752
    Cat. No.:
    HY-11107
    Quantity:

    PHA-665752

    Cat. No.: HY-11107