PROTAC BET degrader-3

製品番号: HY-114229 純度: 99.11%: Data Sheet SDS COA 取扱説明書
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PROTAC BET Degrader-3 is a PROTAC connected by ligands for von Hippel-Lindau and BET.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

PROTAC BET degrader-3 構造式

CAS 番号 : 3031993-61-7

容量	価格（税別）	在庫状況	数量
1 mg	$220	在庫あり	Estimated Time of Arrival: December 31
5 mg	$550	在庫あり	Estimated Time of Arrival: December 31
10 mg	$850	在庫あり	Estimated Time of Arrival: December 31
25 mg	$1850	在庫あり	Estimated Time of Arrival: December 31
50 mg		お問い合わせ
100 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

顧客検証

•Structure. 2024 Dec 5;32(12):2352-2363.e8. [Abstract]

PROTACs アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

生物活性
純度とドキュメンテーション
カスタマーレビュー

製品説明

PROTAC BET Degrader-3 is a PROTAC connected by ligands for von Hippel-Lindau and BET.

IC₅₀ & Target

BET^[1]

分子量

1045.22

分子式

C₅₃H₆₄N₁₂O₉S

CAS 番号

3031993-61-7

Appearance

Solid

Color

Light yellow to yellow

SMILES

CCN1N=C(C2CC2)C=C1NC3=NC(C(NCCOCCOCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O)=O)=NC7=C3C8=CC(OC)=C(C(C(C)=NO9)=C9C)C=C8N7

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (95.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.9567 mL	4.7837 mL	9.5674 mL
5 mM	0.1913 mL	0.9567 mL	1.9135 mL
10 mM	0.0957 mL	0.4784 mL	0.9567 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 99.11%

Select Batch:

データシート (244 KB) SDS (251 KB)

COA (246 KB) HNMR (332 KB) RP-HPLC (226 KB) MS (70 KB)

取扱説明書 (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.9567 mL	4.7837 mL	9.5674 mL	23.9184 mL
	5 mM	0.1913 mL	0.9567 mL	1.9135 mL	4.7837 mL
	10 mM	0.0957 mL	0.4784 mL	0.9567 mL	2.3918 mL
	15 mM	0.0638 mL	0.3189 mL	0.6378 mL	1.5946 mL
	20 mM	0.0478 mL	0.2392 mL	0.4784 mL	1.1959 mL
	25 mM	0.0383 mL	0.1913 mL	0.3827 mL	0.9567 mL
	30 mM	0.0319 mL	0.1595 mL	0.3189 mL	0.7973 mL
	40 mM	0.0239 mL	0.1196 mL	0.2392 mL	0.5980 mL
	50 mM	0.0191 mL	0.0957 mL	0.1913 mL	0.4784 mL
	60 mM	0.0159 mL	0.0797 mL	0.1595 mL	0.3986 mL
	80 mM	0.0120 mL	0.0598 mL	0.1196 mL	0.2990 mL