Pyrithioxin  (Synonyms: Pyritinol; Pyridoxine disulfide; Vitamin B6 disulfide)

Pyrithioxin (Pyritinol) is an orally active neurodynamic compound. Pyrithioxin can promote the metabolism of glucose and amino acids, increase carotid blood flow and improve cerebral blood flow. Pyrithioxin exhibits anti-inflammation, anti-tumor and neuroprotective effect. Pyrithioxin can be used for the researches of cancer, inflammation, immunology, metabolic and neurological disease such as cerebral infarct, epilepsy, fibrosarcomas and rheumatoid polyarthritis^{[1][2][3][4][5][6][7]}.

Pyrithioxin (dihydrochloride) (0.5-3 μg/mL) increases D-arabitol production from Candida parapsilosis by regulating glucose-6-phosphate dehydrogenase^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pyrithioxin (20 mg/kg, i.g., five times a week) prolongs survival time and induces tumor remission in WISTAR rats with 3-MC-induced subcutaneous fibrosarcomas^[2].
Pyrithioxin (200 and 600 mg/kg diet, added to the feed for free consumption, 6 weeks) elevates acetylcholine levels and enhances memory behavior in rats^[4].
Pyrithioxin (50-200 mg/kg, p.o.) reduces flinching behavior in Streptozocin (HY-13753)-induced diabetic rats^[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

368.47

C₁₆H₂₀N₂O₄S₂

1098-97-1

Solid

Off-white to light yellow

OCC1=C(CSSCC2=C(CO)C(O)=C(C)N=C2)C=NC(C)=C1O

Room temperature in continental US; may vary elsewhere.

• [1]. Stoica E, et al. Facilitation through hyperventilation of therapeutic effect of pyrithioxin in cerebral infarct patients. Eur Neurol. 1975;13(4):285-303.  [Content Brief]

  [2]. von Metzler A. et al. [Antineoplastic activity of drugs affecting the central nervous system against chemically induced tumors in the rat (author's transl)]. J Cancer Res Clin Oncol. 1979 Sep;95(1):11-8. German.  [Content Brief]

  [3]. Crouzet J, et al. Pyrithioxine et polyarthrite rhumatoïde [Pyrithioxin and rheumatoid polyarthritis]. Rev Rhum Mal Osteoartic. 1986 Jan;53(1):45-8.  [Content Brief]

  [4]. Marston HM, et al. Effects of the chronic administration of pyrithioxin on behaviour and cholinergic function in young and aged rats. J Psychopharmacol. 1987 Jan;1(4):237-43.  [Content Brief]

  [5]. Zheng S, et al. Combined mutagenesis and metabolic regulation to enhance D-arabitol production from Candida parapsilosis. J Ind Microbiol Biotechnol. 2020 May;47(4-5):425-435.  [Content Brief]

  [6]. Martínez-Lage JM, et al. Asociación de piritioxina y difenilhidantoina, en el tratamiento de los síndromes epilépticos orgánicos [Association of pyrithioxin and diphenylhydantoin in the treatment of organic epileptic syndromes]. Med Clin (Barc). 1965 Sep;45(3):204-5.  [Content Brief]

  [7]. Jiménez-Andrade GY, et al. Pyritinol reduces nociception and oxidative stress in diabetic rats. Eur J Pharmacol. 2008 Aug 20;590(1-3):170-6.  [Content Brief]