Regorafénib N-oxyde (M2)

製品番号: HY-I0678 純度: 99.32%: Data Sheet SDS COA 取扱説明書
FAQs
Technical Support

Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC₅₀s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Regorafénib N-oxyde (M2) 構造式

CAS 番号 : 835621-11-9

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 121	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 121	在庫あり	Estimated Time of Arrival: December 31
Solid
1 mg	$52	在庫あり	Estimated Time of Arrival: December 31
5 mg	$110	在庫あり	Estimated Time of Arrival: December 31
10 mg	$180	在庫あり	Estimated Time of Arrival: December 31
50 mg		お問い合わせ
100 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 0 publication(s) in Google Scholar

Other Forms of Regorafénib N-oxyde (M2):

Regorafénib N-oxyde-d₃(M2) お問い合わせ
Regorafénib N-oxyde (M2)-¹³C,d₃ お問い合わせ
Regorafénib N-oxyde (M2) (Standard) お問い合わせ

PDGFR アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

PDGFR PDGFRβ PDGFRα

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

分子量

498.81

分子式

C₂₁H₁₅ClF₄N₄O₄

CAS 番号

835621-11-9

Appearance

Solid

Color

White to light yellow

SMILES

FC1=CC(OC2=CC=[N+]([O-])C(C(NC)=O)=C2)=CC=C1NC(NC3=CC(C(F)(F)F)=C(Cl)C=C3)=O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 50 mg/mL (100.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0048 mL	10.0239 mL	20.0477 mL
5 mM	0.4010 mL	2.0048 mL	4.0095 mL
10 mM	0.2005 mL	1.0024 mL	2.0048 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 99.32%

Select Batch:

データシート (267 KB) SDS (393 KB)

COA (246 KB) LCMS (96 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Allard M, et al. Simultaneous analysis of regorafenib and sorafenib and three of their metabolites in human plasma using LC-MS/MS. J Pharm Biomed Anal. 2017 Aug 5;142:42-48. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.0048 mL	10.0239 mL	20.0477 mL	50.1193 mL
	5 mM	0.4010 mL	2.0048 mL	4.0095 mL	10.0239 mL
	10 mM	0.2005 mL	1.0024 mL	2.0048 mL	5.0119 mL
	15 mM	0.1337 mL	0.6683 mL	1.3365 mL	3.3413 mL
	20 mM	0.1002 mL	0.5012 mL	1.0024 mL	2.5060 mL
	25 mM	0.0802 mL	0.4010 mL	0.8019 mL	2.0048 mL
	30 mM	0.0668 mL	0.3341 mL	0.6683 mL	1.6706 mL
	40 mM	0.0501 mL	0.2506 mL	0.5012 mL	1.2530 mL
	50 mM	0.0401 mL	0.2005 mL	0.4010 mL	1.0024 mL
	60 mM	0.0334 mL	0.1671 mL	0.3341 mL	0.8353 mL
	80 mM	0.0251 mL	0.1253 mL	0.2506 mL	0.6265 mL
	100 mM	0.0200 mL	0.1002 mL	0.2005 mL	0.5012 mL