2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-116154
    Metacavir 120503-45-9 98%
    Metacavir is an orally active, potent and specific nucleoside reverse transcriptase inhibitor against hepatitis B virus (HBV) with antiviral activity.
    Metacavir
  • HY-116158
    Oosponol 146-04-3 98%
    Oosponol is a dopamine beta-hydroxylase inhibitor exhibiting hypotensive effects.Oospongol has strong antifungal activity against many antagonistic fungi.
    Oosponol
  • HY-116182
    RO5487624 1399103-28-6 98%
    RO5487624, an analogue of RO5464466 (HY-120690), is an orally active hemagglutinin (HA) inhibitor of influenza H1N1 viruses that abolishes influenza virus fusion by blocking HA conformational changes in low pH environments. RO5487624 displays a protective effect on mice that are lethally challenged with influenza H1N1 virus.
    RO5487624
  • HY-116183
    ITX 4520 1392116-37-8 98%
    ITX 4520 is an orally active and potent hepatitis C virus inhibitor exhibiting an excellent PK profile in both rats and dogs.
    ITX 4520
  • HY-116240
    2′,3′-Dideoxy-5-ethyluridine 108895-49-4 98%
    2′,3′-Dideoxy-5-ethyluridine (ddEtUrd) is an antiretroviral compound with weak anti-HIV activity. The 3'-substituted derivatives of 2′,3′-Dideoxy-5-ethyluridine did not show significant antiviral effects. 2′,3′-Dideoxy-5-ethyluridine was less potent in inhibiting HIV replication in human MT4 lymphocytes. Although phosphorylation induced by 2′,3′-Dideoxy-5-ethyluridine is essential for antiviral activity, there is no strong correlation between its affinity for human dThd kinase or dCyd kinase.
    2′,3′-Dideoxy-5-ethyluridine
  • HY-116433
    Nequinate 13997-19-8 98%
    Nequinate, a quinoline compound, is an anticoccidial agent against cecal coccidiosis (Eimeria tenella) infections. Nequinate inhibits xanthine oxidoreductase (XOD) activity.
    Nequinate
  • HY-116454
    GSK5750 1312345-89-3 98%
    GSK5750 is a specific and potent HIV-1 reverse transcriptase ribonuclease H inhibitor with an IC50 value of 0.33 μM. GSK5750 is bound at the RNase H active site through a metalion chelation mechanism.
    GSK5750
  • HY-116511
    Benzoximate 29104-30-1 98%
    Benzoximate is an acaricide that inhibits fruit tree red spider mite Panonychys ulmi (Koch).
    Benzoximate
  • HY-116528
    GCA-186 149950-61-8 98%
    GCA-186 is a potent anti-HIV-1 agent. GCA-186 is highly active against both wild type and mutated HIV-1 strains with EC50s of 1, 180, 1, and 40 nM for IIIB, IIIB-R(Y181C), NL4-3 and NL4-3K103N of HIV-1 strains, respectively.
    GCA-186
  • HY-116537
    A76889 134805-77-9 98%
    A76889 is an HIV-1 protease inhibitor.
    A76889
  • HY-116620
    Benzomalvin C 157047-98-8 98%
    Benzomalvin C is a weak antagonist of the neurokinin-1 (NK1) receptor inhibiting binding of substance P by 46% when used at 100 μg/mL in vitro. It is also a weak inhibitor of indolamine 2,3-dioxygenase (IDO) with an IC50 value of 130 μM for recombinant IDO. It is isolated from Penicillium and contains an epoxide group at C-19 and C-20, which is not present in benzomalvins A, B, or E.
    Benzomalvin C
  • HY-116633
    BCM-599 1820763-99-2 98%
    BCM-599 is a HBV (hepatitis B virus) capsid assembly inhibitor with the activity of inhibiting HBV capsid assembly. BCM-599 showed an IC50 value of 0.88μM and a CC50 value of 144μM in HepG2.2.15 cells. When used in combination with lamivudine, BCM-599 showed a synergistic inhibitory effect on viral concentration. BCM-599 can be used as an effective combined inhibition option for HBV infection.
    BCM-599
  • HY-116639
    Javanicin 476-45-9 98%
    Javanicin is an antibacterial agent with certain antibacterial activity against pathogenic bacteria such as Bacillus megaterium, Staphylococcus aureus, Salmonella typhi, and Escherichia coli. Javanicin has weak cytotoxicity against the human lung cancer cell line.
    Javanicin
  • HY-116681
    Aflavarin 144429-67-4 98%
    Aflavarin is produced from cluster 39 expressed mainly in sclerotia. Aflavarin exhibits anti-insectan activity .
    Aflavarin
  • HY-116694
    Digallic acid 536-08-3 98%
    Digallic acid is an antioxidant, antimutagenic, antigenotoxic, and anti-hyperuricemic compound. Digallic acid is a reverse transcriptase and XOD, URAT1 (IC50: 5.34 μM) inhibitor. Digallic acid scavenges DPPH· and O2·− radicals. Digallic acid induces apoptosis. Digallic acid can be isolated from the fruits of Pistascia lentiscus.
    Digallic acid
  • HY-116696
    GSK3-IN-11 681432-07-5 98%
    GSK3-IN-11 is a Glycogen Synthase Kinase-3 (GSK-3) inhibitor with an IC50 of 5010 nM.
    GSK3-IN-11
  • HY-116700
    Hinnuliquinone 78860-37-4 98%
    Hinnuliquinone is a C2-symmetric dimeric non-peptide fungal metabolite inhibitor of HIV-1 protease. Hinnuliquinone is a bis-indolyl-2,5-dihydroxybenzoquinone pigment, that can be isolated from Nodulisphorium hinnuleum.
    Hinnuliquinone
  • HY-116713
    PfDHODH-IN-3 92872-51-0 99.74%
    PfDHODH-IN-3 (compound 2) is an orally active PfDHODH inhibitor with strong antimalarial activity (IC50=47 nM). PfDHODH-IN-3 can inhibit the growth of Plasmodium in animals.
    PfDHODH-IN-3
  • HY-116758
    16,16-Dimethyl prostaglandin A1 41692-24-4 98%
    16,16-Dimethyl prostaglandin A1 (di-Me-PGA1) is a prostaglandin analog that can inhibit DNA synthesis in Lewis lung carcinoma and B 16 amelanotic melanoma cells. 16,16-Dimethyl prostaglandin A1 also inhibits viral replication in both HSV and HIV-1 infection systems.
    16,16-Dimethyl prostaglandin A1
  • HY-116866
    Sclerotiorin 549-23-5 98%
    Sclerotiorin is a reversible and uncompetitive inhibitor against soybean lipoxygenase-1 (LOX-1) (IC50: 4.2 μM). Sclerotiorin also shows antioxidant activity by scavenging free radical (ED50: 0.12 μM), and nonenzymatic lipid peroxidation inhibition activity. Sclerotiorin has antifungal activity, and also inhibits platelet aggregation. Sclerotiorin can be purified from the fermented broth of Penicillium frequentans.
    Sclerotiorin
Cat. No. Product Name / Synonyms Application Reactivity