Infection

Catenarin, an anthraquinone compound, inhibits CCR5- and CXCR4-mediated chemotaxis. Catenarin reduces the phosphorylation of mitogen-activated protein kinases (p38 and JNK) and their upstream kinases (MKK6 and MKK7), and calcium mobilization. Catenarin shows anti-inflammatory effect and suppresses leukocyte migration in the diabetes. Catenarin exhibits significant inhibitory effects against Gram-positive bacteria. Catenarin prevents type 1 diabetes (T1D) in nonobese diabetic mice^[1][2].

Nerelimomab (BAYX1351) is an anti-TNF-α antibody. Nerelimomab can be used for research of sepsis.

Remdesivir maleate (GS-5734 maleate) is a nucleoside analogue with effective antiviral activity. Remdesivir maleate can inhibit the synthesis of viral DNA or RNA. Remdesivir maleate can be used for the research of infection, such as SARS-CoV and MHV infection.

PTD-N5-1 acetate is an IRF5 inhibitory peptide. PTD-N5-1 acetate blocks the activation of IRF5. PTD-N5-1 acetate inhibits β-glucan-induced IL-12 production in bone marrow-derived dendritic cells pre-stimulated with IFN-γ. PTD-N5-1 acetate reduces the levels of IL-12 and IFN-γ in the kidneys of mice with Candida albicans infection. PTD-N5-1 acetate is applicable to the research of Candida albicans infection.

β-defesin 1 (pig) (pBD-1) is an endogenous and constitutively expressed antimicrobial peptide (AMP) from porcine tissues, particularly expresses in pig mucosal epithelial sites. β-defesin 1 (pig) has antimicrobial activities and contributes to mucosal and systemic host defenses in pigs.

NS2B/NS3-IN-7 (compound 26) is a highly potent Zika virus NS2B-NS3 protease inhibitor with a K_i value of 2.33 nM. NS2B/NS3-IN-7 can reduce amounts of ZIKV-infected cells.

Anti-Mouse Notch4 Antibody (HMN4-14) is an anti-mouse Notch4 IgG monoclonal antibody. Anti-Mouse Notch4 Antibody (HMN4-14) reduces inflammation by restoring the expression of bispecific proteins. Anti-Mouse Notch4 Antibody (HMN4-14) can inhibit Th2/Th17 cell differentiation and improve Treg cell function. Anti-Mouse Notch4 Antibody (HMN4-14) can be used for research on inflammation conditions such as viral pneumonia and airway inflammation.

NBTIs-IN-5 (Compound 5r) is a NBTI (Novel Bacterial Topoisomerase Inhibitor) DNA gyrase inhibitor with an IC₅₀ of 1.5 μM against Mycobacterium abscessus (Mabs) DNA gyrase. NBTIs-IN-5 inhibits Mabs bamboo bacterial growth with an MIC₉₀ of 0.4 μM.

SmCB1-IN-1 (Compound 2h) is an inhibitor for S. mansoni cathepsin B1 (SmCB1) with an K_i of 0.05 μM. SmCB1-IN-1 exhibits selectivity toward human off-target cathepsins (29% and 37% inhibition for CatB and CatL at 20 μM). SmCB1-IN-1 inhibits 68% Schistosoma mansoni at 1 μM.

H-Pro-Glu-OH is a protein secreted by pathogenic mycobacteria through the Type VII secretion system. H-Pro-Glu-OH targets LipY lipases to the cell Surface via the ESX-5 Pathway.

Antibacterial agent 70 is an antibacterial agent that interacts with DNA, with a MIC value of 0.5 μg/mL against K. pneumonia and A. baumanii. Antibacterial agent 70 exhibits rapid bactericidal activity, low cytotoxicity to mammalian cells, and low tendency to induce drug resistance. Antibacterial agent 70 intercalates into DNA, disrupts bacterial membrane integrity, increases intracellular ROS production, reduces GSH activity, regulates membrane depolarization, enhances outer membrane permeability, and induces inner membrane damage. Antibacterial agent 70 can be used in studies related to multidrug-resistant bacterial infections and infections caused by drug-resistant Gram-negative pathogens.

Soulattrolide is a non-nucleoside HIV-1 reverse transcriptase (RT) inhibitor with IC₅₀ values of 0.34 µM for HIV-1 RT, 69.5 µM for E. coli RNase H, and >495 µM for human DNA polymerase β, and can be found in Calophyllum teysmannii latex. Soulattrolide can be used for the research of HIV-1 infection, pain, inflammation, and Mycobacterium tuberculosis infection.

(2R,4R)-UCB7362 is the (2R,4R) isomer of UCB7362 (HY-151568). UCB7362 is an inhibitor of plasma proteinase X (PMX) with antimalarial activity.

Cefazolin (sodium) (Standard) is the analytical standard of Cefazolin (sodium). This product is intended for research and analytical applications. Cefazolin sodium is a first-generation cephalosporin antibiotic and can be used in varieties of bacterial infections research. Cefazolin sodium has anti-inflammatory effect and can attenuate post-operative cognitive dysfunction (POCD).

Smilax glabra extract possesses a variety of benefits, including anti-inflammatory, antioxidant, antibacterial, and anticancer properties. It contains numerous active ingredients, such as dihydroflavonol glycosides (e.g., asstebin and neo-asstebin), flavonol glycosides, and steroidal saponins, including smilax saponin.

DPC 684 is a potent and selective HIV-1 protease inhibitor (IC₉₀ = 5.7-40 nM, Ki = 0.021 nM). DPC 684 competitively inhibits HIV-1 protease and blocks viral polyprotein cleavage. DPC 684 has low protein binding and broad-spectrum inhibition against a variety of wild-type and mutant HIV-1 proteases. DPC 684 has low protein binding and broad-spectrum inhibition (IC₉₀ = 1.9-6.3 nM). DPC 684 has research significance for HIV.

Peptide 5f is an antimicrobial peptide derived from wasp venom. Peptide 5f has antimicrobial activity against bacteria and fungi. Peptide 5f has little hemolytic activity on human red blood cells .

Soladulcidine, as an anticancer steroidal alkaloid, possesses antifungal and induction of congenital craniofacial malformation activities.

CBS1194 is a selective group 2 influenza virus inhibitor. CBS1194 binds to the pocket region adjacent to the HA fusion peptide, generates steric hindrance, and blocks the low pH-induced HA conformational rearrangement required for membrane fusion. CBS1194 exerts inhibitory activity in the early stage of viral infection and can inhibit HA-mediated hemolysis. CBS1194 serves as a lead compound for the development of improved influenza virus entry inhibitors. CBS1194 is applicable to studies related to influenza virus infection.

Vanillic acid 4-O-β-D-glucopyranoside is a vanillic acid glycoside with moderate antioxidant activity. Vanillic acid 4-O-β-D-glucopyranoside scavenges DPPH free radicals and superoxide anion radicals, and inhibits AAPH-induced lipid peroxidation in the linoleic acid system. The IC₅₀ value of Vanillic acid 4-O-β-D-glucopyranoside against HIV-1 integrase is >100 μg/mL, indicating that it is not an effective HIV-1 integrase inhibitor. Vanillic acid 4-O-β-D-glucopyranoside is isolable from the ethyl acetate extract of Gardeniae Fructus.