2′,3′-Dideoxy-5-ethyluridine
2′,3′-Dideoxy-5-ethyluridine (ddEtUrd) is an antiretroviral compound with weak anti-HIV activity. The 3'-substituted derivatives of 2′,3′-Dideoxy-5-ethyluridine did not show significant antiviral effects. 2′,3′-Dideoxy-5-ethyluridine was less potent in inhibiting HIV replication in human MT4 lymphocytes. Although phosphorylation induced by 2′,3′-Dideoxy-5-ethyluridine is essential for antiviral activity, there is no strong correlation between its affinity for human dThd kinase or dCyd kinase.
For research use only. We do not sell to patients.
- CAS No.: 108895-49-4
- Formula: C11H16N2O4
- Molecular Weight:240.26
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Huh-7 | CC50 |
>100 μg/mL
Compound: 13
|
Cytotoxicity against human HuH7 cells by [3H]thymidine incorporation assay
Cytotoxicity against human HuH7 cells by [3H]thymidine incorporation assay
|
[PMID: 22178557] |
| Huh-7 | CC50 |
>100 μg/mL
Compound: 13
|
Cytotoxicity against human HuH7 cells by XTT assay
Cytotoxicity against human HuH7 cells by XTT assay
|
[PMID: 22178557] |
Chemical Information
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CAS No. 108895-49-4
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Molecular Weight 240.26
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Formula C11H16N2O4
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SMILES
OC[C@@H]1CC[C@H](N2C=C(CC)C(NC2=O)=O)O1
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Synonyms
ddEtUrd
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)