108895-49-4
Chemical Structure
2′,3′-Dideoxy-5-ethyluridine
Synonym(s): ddEtUrd
- CAS No.: 108895-49-4
- Formula:C11H16N2O4
- Molecular Weight:240.26
IUPAC Name: 5-ethyl-1-((2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
InChIKey: MCKZMXMWYDOXBL-DTWKUNHWSA-N
SMILES: OC[C@@H]1CC[C@H](N2C=C(CC)C(NC2=O)=O)O1
Biological Activity: 2′,3′-Dideoxy-5-ethyluridine (ddEtUrd) is an antiretroviral compound with weak anti-HIV activity. The 3'-substituted derivatives of 2′,3′-Dideoxy-5-ethyluridine did not show significant antiviral effects. 2′,3′-Dideoxy-5-ethyluridine was less potent in inhibiting HIV replication in human MT4 lymphocytes. Although phosphorylation induced by 2′,3′-Dideoxy-5-ethyluridine is essential for antiviral activity, there is no strong correlation between its affinity for human dThd kinase or dCyd kinase[1].
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2′,3′-Dideoxy-5-ethyluridine | 2′,3′-Dideoxy-5-ethyluridine (ddEtUrd) is an antiretroviral compound with weak anti-HIV activity. The 3'-substituted derivatives of 2′,3′-Dideoxy-5-ethyluridine did not show significant antiviral effects. 2′,3′-Dideoxy-5-ethyluridine was less potent in inhibiting HIV replication in human MT4 lymphocytes. Although phosphorylation induced by 2′,3′-Dideoxy-5-ethyluridine is essential for antiviral activity, there is no strong correlation between its affinity for human dThd kinase or dCyd kinase. | |||||||||||||||||||||
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