Sclerotiorin
Sclerotiorin is a reversible and uncompetitive inhibitor against soybean lipoxygenase-1 (LOX-1) (IC50: 4.2 μM). Sclerotiorin also shows antioxidant activity by scavenging free radical (ED50: 0.12 μM), and nonenzymatic lipid peroxidation inhibition activity. Sclerotiorin has antifungal activity, and also inhibits platelet aggregation. Sclerotiorin can be purified from the fermented broth of Penicillium frequentans.
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- CAS No.: 549-23-5
- Formule: C21H23ClO5
- Masse moléculaire:390.86
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Help & FAQs
Activité biologique
Sclerotiorin (10 μM) slows Aβ42 fibrillogenesis in vitro, detected with 6E10 antibody[2].
Sclerotiorin shows narrow spectrum activity against Gram positive bacteria, with MIC range of 128-1028 μg/mL[3].
Sclerotiorin inhibits cholesteryl ester transfer protein (CETP) activity in vitro (IC50: 19.4 μM)[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 549-23-5
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Masse moléculaire 390.86
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Formule C21H23ClO5
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SMILES
O=C1[C@](C)(OC(C)=O)C(C2=COC(/C=C/C(C)=C/[C@@H](C)CC)=CC2=C1Cl)=O
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Structure Classification
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Initial Source
Penicillium multicolor
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sclerotiorin Related Classifications
HY-116866 Related Classifications
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