Sclerotiorin

Cat. No.: HY-116866: FAQs
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Sclerotiorin is a reversible and uncompetitive inhibitor against soybean lipoxygenase-1 (LOX-1) (IC₅₀: 4.2 μM). Sclerotiorin also shows antioxidant activity by scavenging free radical (ED₅₀: 0.12 μM), and nonenzymatic lipid peroxidation inhibition activity. Sclerotiorin has antifungal activity, and also inhibits platelet aggregation. Sclerotiorin can be purified from the fermented broth of Penicillium frequentans.

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Sclerotiorin Chemical Structure

CAS No. : 549-23-5

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Description	Sclerotiorin is a reversible and uncompetitive inhibitor against soybean lipoxygenase-1 (LOX-1) (IC₅₀: 4.2 μM). Sclerotiorin also shows antioxidant activity by scavenging free radical (ED₅₀: 0.12 μM), and nonenzymatic lipid peroxidation inhibition activity. Sclerotiorin has antifungal activity, and also inhibits platelet aggregation. Sclerotiorin can be purified from the fermented broth of Penicillium frequentans^[1]^[2].
In Vitro	Sclerotiorin (10 μM) slows Aβ42 fibrillogenesis in vitro, detected with 6E10 antibody^[2]. Sclerotiorin shows narrow spectrum activity against Gram positive bacteria, with MIC range of 128-1028 μg/mL^[3]. Sclerotiorin inhibits cholesteryl ester transfer protein (CETP) activity in vitro (IC₅₀: 19.4 μM)^[4]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Sclerotiorin Related Antibodies
Molecular Weight	390.86
Formula	C₂₁H₂₃ClO₅
CAS No.	549-23-5
SMILES	O=C1[C@](C)(OC(C)=O)C(C2=COC(/C=C/C(C)=C/[C@@H](C)CC)=CC2=C1Cl)=O
Structure Classification	Others
Initial Source	Microorganisms Penicillium multicolor
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (247 KB) Handling Instructions (2659 KB)

Sclerotiorin Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sclerotiorin549-23-5LipoxygenaseFungalLOXantioxidantradicallipid peroxidationantifungalplatelet aggregationInhibitorinhibitorinhibit

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