RO5487624
RO5487624, an analogue of RO5464466 (HY-120690), is an orally active hemagglutinin (HA) inhibitor of influenza H1N1 viruses that abolishes influenza virus fusion by blocking HA conformational changes in low pH environments. RO5487624 displays a protective effect on mice that are lethally challenged with influenza H1N1 virus.
For research use only. We do not sell to patients.
- CAS No.: 1399103-28-6
- Formula: C16H25ClN2O3S
- Molecular Weight:360.90
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDCK | CC50 |
71.2 μM
Compound: 40
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Cytotoxicity against MDCK cells after 3 days by MTT assay
Cytotoxicity against MDCK cells after 3 days by MTT assay
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[PMID: 24900355] |
| MDCK | EC50 |
0.086 μM
Compound: 40
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Antiviral activity against Influenza A virus (A/Weiss/1943(H1N1)) infected in MDCK cells assessed as inhibition of virus-induced cytopathic effects after 3 days by MTT assay
Antiviral activity against Influenza A virus (A/Weiss/1943(H1N1)) infected in MDCK cells assessed as inhibition of virus-induced cytopathic effects after 3 days by MTT assay
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[PMID: 24900355] |
Chemical Information
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CAS No. 1399103-28-6
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Molecular Weight 360.90
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Formula C16H25ClN2O3S
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SMILES
O=S(C1=CC(NC[C@]2(C)CC(C)(C)C[C@H](O)C2)=CC=C1Cl)(N)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RO5487624 Related Classifications
HY-116182 Related Classifications
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