Infection

Anti-PEDV agent 1 (Compound D39) is a highly effective anti-Porcine epidemic diarrhea virus (PEDV) agent with an EC₅₀ value of 0.09 μM. Anti-PEDV agent 1 blocks the early internalization of PEDV during viral entry by modulating intracellular Ca²⁺ homeostasis. Anti-PEDV agent 1 is promising for research of PEDV infections.

Prenylterphenyllin (Compound 1) is an antibacterial agent. Prenylterphenyllin can be isolated from marine-derived fungus Aspergillus candidus IF10. Prenylterphenyllin has cytotoxic activity against KB3-1 cells with an IC₅₀ of 8.5 mg/mL. Prenylterphenyllin also has antibacterial activities against Xanthomonas oryzae and Erwinia amylovora with MICs of both 20 μg/mL.

ddATP (2',3'-Dideoxyadenosine 5'-triphosphate), an active metabolite of 2',3'-dideoxyinosine, is a chain-elongating inhibitor of DNA polymerase. ddATP can be used for Sanger method for DNA sequencing and research of virus infection.

Benanomicin A is a microbial metabolite and can be isolated from Actinomycetes.Benanomicin has antifungal activitya and inhibits HIV-1 viral infection in MT-4 cells.

Butenafine-¹³C,d₃ (hydrochloride) is the ¹³C- and deuterium labeled. Butenafine Hydrochloride (KP363 Hydrochloride) is a synthetic benzylamine antifungal, works by inhibiting the synthesis of sterols by inhibiting squalene epoxidase.

BIBX 1382 dihydrochloride is an ErbB kinase inhibitor with significant antiviral activity. BIBX 1382 affects the ability of viruses to enter host cells by inhibiting members of the ErbB kinase family. It can be used to study the interaction mechanism between virus and host and the broad spectrum intervention of highly pathogenic viruses.

IQP-0528 (Standard) is the analytical standard of IQP-0528. This product is intended for research and analytical applications. IQP-0528 is a highly potent nonnucleoside reverse transcriptase inhibitor (NNRTI). IQP-0528 shows nanomolar activity against both HIV-1 and HIV-2, with an HIV-1 EC50 of 0.2 nM and an HIV-2 EC50 of 100 nM.

Antifungal agent 26, a Pradimicin A derivative, shows antifungal, antiviral, and antiparasitic activities through binding to d-mannose (Man)-containing glycans of pathogenic species.

Salbostatin is a competitive Trehalase inhibitor, with an IC₅₀ of 8.3 μM against silkworm trehalase and a K_i of 180 nM against porcine trehalase. Salbostatin is isolated from Streptomyces albus. Salbostatin shows no antibacterial activity, and does not inhibit porcine intestinal mucosa sucrase (EC 3.2.1.26) or maltase (EC 3.2.1.20). Salbostatin can be used in studies related to the development of plant protectants.

Phenoxan is an inhibitor of cytochrome b and NADH: ubiquinone oxidoreductase. It exerts anti-HIV, antifungal, and cytotoxic effects by inhibiting the electron transport chain, the activity of HIV-1 Reverse Transcriptase, and viral replication. Phenoxan can be used in studies of HIV-1 infection and fungal infections.

Cinchona ledgeriana extract, derived from the cinchona tree, is rich in alkaloids such as quinine and quinidine, and has antimalarial, anti-inflammatory, analgesic, and antioxidant effects.

Xalnesiran sodium scrambled negative control is the sequence scrambled negative control of Xalnesiran sodium.

SARS-CoV-2-IN-10 is a potent and nontoxic inhibitor of SARS-CoV-2 3CL protease (3CLpro) with an IC₅₀ and EC₅₀ of 0.13 and 1.03 nM, respectively. SARS-CoV-2 3C-like protease (3CLpro), an enzyme essential for viral replication, is an attractive target for intervention. SARS-CoV-2-IN-11 may lead to the emergence of effective SARS-CoV-2-specific antivirals.

Crassicauline A (Crassicaulin A) Standard is the analytical standard of Crassicauline A (HY-N1924). This product is intended for research and analytical applications. Crassicauline A (Crassicaulin A) is a diester-type diterpenoid alkaloid. Crassicauline A exhibits feeding deterrent activity against adult Tribolium castaneum, with a EC₅₀ of 1134.5 ppm. Crassicauline A induces arrhythmia at a dose of 0.10 mg/kg.

Apolactoferrin is an iron-free form of lactoferrin with antiparasitic activity. Apolactoferrin is an iron-binding protein.

LC-1310 is an antiviral agent that targets and inhibits p97, and it suppresses the in vitro replication of human cytomegalovirus (HCMV) with an EC₅₀ value of 0.3 μM. LC-1310 targets the D2 ATP-binding site of p97, downregulates the expression of early viral proteins, thereby blocking the transcription and proliferation of early viral genes. LC-1310 can be used for research on human cytomegalovirus infection.

SARS-CoV-2 nsp13-IN-6 (compound C5) is a potent SARS-CoV-2 non-structural protein 13 (nsp13) inhibitor with IC₅₀ values of 27 and 33 μM for ssDNA⁺ ATPase and ssDNA^- ATPase. SARS-CoV-2 nsp13-IN-6 can be used for researching anti-COVID-19.

cis-2-Butene-1,4-diol serves as a probe for investigating isomerization and hydrogenation/hydrogenolysis reactions. cis-2-Butene-1,4-diol is also a compound used in the synthesis of the antiviral agent Oxetanocin A. cis-2-Butene-1,4-diol undergoes hydrogenation and hydrogenolysis reactions over supported platinum catalysts, with negligible levels of isomerization.

Ertapenem-d₄ (disodium) is deuterium labeled Ertapenem (disodium).

ST-148 is a novel small molecule compound that has potent inhibitory effects against all four dengue virus serotypes. In the nonlethal AG129 mouse dengue virus infection model, ST-148 significantly reduced viremia and viral load in vital organs and tended to reduce plasma cytokine levels. Compound resistance was associated with the dengue virus capsid (C) gene, and the direct interaction of ST-148 with the C protein was presumed to be achieved through the protein's built-in fluorescence change in the presence of the compound. Therefore, ST-148 appears to interact with the dengue virus C protein and inhibit one or more unique steps of the viral replication cycle.