2. Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-174816
    DHODH-IN-28
    DHODH-IN-28 (Compound 11a) is a potent fluorescent inhibitor targeting human dihydroorotate dehydrogenase (hDHODH) with an IC50 value of 170 nM. DHODH-IN-28 exhibits antileukemic and antiviral activities. DHODH-IN-28 is promising for research of cancers and infectious diseases.
    DHODH-IN-28
  • HY-174857
    HBeAg ligand 1 2361022-13-9
    HBeAg ligand 1 (Compound S2) is a HBeAg inhibitor. HBeAg ligand 1 can be used for synthesis of PROTAC HBeAg degrader-1 (HY-174856).
    HBeAg ligand 1
  • HY-174973
    CYP51-IN-26 98%
    CYP51-IN-26 is a CYP51 inhibitor with an IC50 value of approximately 0.40 μM. CYP51-IN-26 eradicates C. auris biofilms. CYP51-IN-26 demonstrates significantly improved intracellular uptake in an accumulation assay. CYP51-IN-26 protects against C. auris infection in both G. mellonella and D. melanogaster models. CYP51-IN-26 can be used for research on fungal infections.
    CYP51-IN-26
  • HY-174980
    KPC-2-IN-3 98%
    KPC-2-IN-3 (Compound 3b) is a KPC-2 inhibitor with IC50 of 0.533  μM and Kiof 0.194  μM. KPC-2-IN-3 has an antimicrobial activity against carbapenem-resistant K. pneumonia K47-25 and reduces bacterial count with a postantibiotic effect in synergy with Meropenem (HY-13678). KPC-2-IN-3 significantly reduces lung bacterial load in a murine pneumonia model.
    KPC-2-IN-3
  • HY-174985
    Anti-MRSA agent 32
    Anti-MRSA agent 32 (Compound 26) is an orally active and selective SaClpP (Staphylococcus aureus ClpP protease) activator with an EC50 value of 0.98 μM. Anti-MRSA agent 32 activates SaClpP to abnormally degrade bacterial proteins, inhibiting the proliferation of Staphylococcus aureus. Anti-MRSA agent 32 promotes wound healing in a murine skin infection model. Anti-MRSA agent 32 is promising for research of infectious diseases such as methicillin-resistant Staphylococcus aureus (MRSA) infections.
    Anti-MRSA agent 32
  • HY-175007
    RIPK1-IN-32 98%
    RIPK1-IN-32 is a RIPK inhibitor with anti-inflammatory activity. RIPK1-IN-32 inhibits nitric oxide (NO) release with an IC50 of 3.26 μM. RIPK1-IN-32 significantly alleviates acute liver injury associated with sepsis through the RIPK1/NF-κB/MAPK pathway, therefore preventing the nuclear translocation of p65 and c-fos, which results in reduced expression of TNF-α and IL-6. RIPK1-IN-32 can be used for the study of acute liver injury and sepsis.
    RIPK1-IN-32
  • HY-17503C
    Metoprolol fumarate 80274-67-5 98%
    Metoprolol fumarate (CGP 2175C) is an orally active, selective β1-adrenoceptor antagonist. Metoprolol fumarate shows anti-inflammation, antitumor and anti-angiogenic properties.
    Metoprolol fumarate
  • HY-175044
    (±)14(15)-EET Ethanolamide 1469713-10-7 98%
    (±)14(15)-EET Ethanolamide ((±)14(15)-Epoxy eicosatrienoyl ethanolamide) is a fatty acid monoepoxide. (±)-14(15)-EET ethanolamide can be used in the research of Pseudomonas aeruginosa infections and respiratory diseases.
    (±)14(15)-EET Ethanolamide
  • HY-175136
    Chloroguanabenz acetate 2242615-97-8
    Chloroguanabenz (acetate) is an antiprion agent and a derivative of the α2-adrenergic receptor agonist guanabenz. Chloroguanabenz (acetate) can inhibit the formation of prion in yeast and mammalian in vitro assays. Chloroguanabenz (acetate) can reduce the levels of truncated Huntingtin derivative Htt48 in HEK293T cells. Chloroguanabenz (acetate) can be studied in research on Huntington’s disease.
    Chloroguanabenz acetate
  • HY-175196
    P2X7 receptor antagonist-6 1114621-31-6
    P2X7 receptor antagonist-6 (Compound 2g) is a negative allosteric P2X7 receptor antagonist with an IC50 of 1.31  μM for hP2X7. P2X7 receptor antagonist-6 can be used for cancer, neurodegenerative, inflammatory, and infectious diseases research.
    P2X7 receptor antagonist-6
  • HY-175237
    Cholesterol oxidase-IN-1
    Cholesterol oxidase-IN-1 (Compound 4) is a Cholesterol oxidase inhibitor. Cholesterol oxidase-IN-1 has a superior binding affinity on cholesterol oxidase. Cholesterol oxidase-IN-1 can be used for infections and inflammatory diseases research.
    Cholesterol oxidase-IN-1
  • HY-175259
    DHODH-IN-29 212375-00-3
    DHODH-IN-29 (Compound 2i) is a covalent inhibitor of Leishmania braziliensis Dihydroorotate Dehydrogenase (LbDHODH) with an IC50 value of 0.5 μM. DHODH-IN-29 is promising for research of antileishmaniasis.
    DHODH-IN-29
  • HY-175304
    DMU371 3052352-34-5
    DMU371 is a Trypanosoma cruzi lysyl-tRNA synthetase 1 (KRS1) inhibitor (IC50=185 nM). DMU371 is promising for research of infectious diseases.
    DMU371
  • HY-175305
    DMU759 3052352-22-1 98%
    DMU759 is a Lysyl-tRNA synthetase 1 (KRS1) inhibitor. DMU759 has potent anti-kinetoplastid activity against Trypanosoma cruzi , Trypanosoma brucei and Leishmania donovani. DMU759 significantly reduces parasitemia in acute Chagas disease mice model. DMU759 can be used for parasitic infection like Chagas disease research.
    DMU759
  • HY-17530R
    Aldicarb sulfone (Standard) 1646-88-4
    Aldicarb sulfone (Standard) is the analytical standard of Aldicarb sulfone (HY-17530). This product is intended for research and analytical applications. Aldicarb sulfone is one of the metabolites of the carbamate pesticide Aldicarb and has insecticidal activity. Aldicarb sulfone is also an inhibitor of cholinesterase.
    Aldicarb sulfone (Standard)
  • HY-17530S
    Aldicarb sulfone-13C2,d3 1261170-76-6 98%
    Aldicarb sulfone-13C2,d3 is the deuterium and 13C labeled Aldicarb sulfone (HY-17530). Aldicarb sulfone is one of the metabolites of the carbamate pesticide Aldicarb and has insecticidal activity. Aldicarb sulfone is also an inhibitor of cholinesterase.
    Aldicarb sulfone-13C2,d3
  • HY-175343
    OICR-41103 98%
    OICR-41103 is an effective, selective, cell-active DCAF1 small molecule chemical probe that targets the DCAF1 WDR domain and replaces the viral Vpr protein. The binding Ki value of OICR-41103 and DCAF1 is less than 2 nM.
    OICR-41103
  • HY-175344
    TMP1 98%
    TMP1 is an orally active bispecific inhibitor of M pro (IC50 = 312.5 nM)/TMPRSS2 (IC50 = 1.28 μM, KD = 10.10 μM). TMP1 exhibits broad protection against different SARS-CoV-2 variants in vitro. TMP1 cross-protects against highly pathogenic coronaviruses (SARS-CoV-1, SARS-CoV-2, and MERS-CoV) in vivo and effectively blocks the transmission of SARS-CoV-2. TMP1 can inhibit infection by SARS-CoV-2 escape mutants that are resistant to Nivolumab (HY-P9903). TMP1 can be used in coronavirus research.
    TMP1
  • HY-175351
    HIV-1-IN-83
    HIV-1-IN-83 (Compound 18E) is a HIV-1 non-nucleoside reverse transcriptase inhibitor with an IC50 of 0.45 μM for wild-type HIV-1 non-nucleoside reverse transcriptase. HIV-1-IN-83 has potent antiviral activity against both HIV-1 wild-type and mutant strains and improves antidrug resistance for Y188L and RES056 mutant strains. HIV-1-IN-83 has no significant toxicity up to 11.088 μM.
    HIV-1-IN-83
  • HY-175363
    HIV-1-IN-84
    HIV-1-IN-84 (Compound 9) is a potent HIV-1 non-nucleoside reverse transcriptase (HIV-1 RT) inhibitor (IC50=33.89 μM, EC50=540 nM). HIV-1-IN-84 is promising for research of HIV infections.
    HIV-1-IN-84
Cat. No. Product Name / Synonyms Application Reactivity