CYP51-IN-26
CYP51-IN-26 is a CYP51 inhibitor with an IC50 value of approximately 0.40 μM. CYP51-IN-26 eradicates C. auris biofilms. CYP51-IN-26 demonstrates significantly improved intracellular uptake in an accumulation assay. CYP51-IN-26 protects against C. auris infection in both G. mellonella and D. melanogaster models. CYP51-IN-26 can be used for research on fungal infections.
For research use only. We do not sell to patients.
- Formula: C20H22F3N7O
- Molecular Weight:433.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
CYP51-IN-26 (Compound 7) accumulates to significantly higher levels than Fluconazole (HY-B0101) in C. auris strain TDG1912[1]. CYP51-IN-26 shows antifungal activity to C.albicans NCNCPF3281(0.125 μg/mL), N.glabratus NCPF8018 (0.25 μg/mL), C.tropicalis NCPF8760 (0.25 μg/mL), C.parapsilosis NCPF3209 (0.125 μg/mL), TDG19 12 (0.25 μg/mL), TDG25 12 (0.06 μg/mL), TDG11 02 (4 μg/mL), TDG22 11 (0.5 μg/mL), TDG25 06 (≤ 0.03 μg/mL), NCPF89 84 (≤ 0.03 μg/mL), NCPF8971 (≤ 0.25 μg/mL) and NCPF8977 (≤ 0.03 μg/mL)[1]. CYP51-IN-26 (0.03-64 μg/mL, 24 h) significantly reduces biofilm biomass, exhibiting eradication activity comparable to Voriconazole (HY-76200)[1]. CYP51-IN-26 (0-25 h) demonstrates inhibition of C. auris TDG1912 growth for at least 6 hours of incubation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:G. mellonella larvae were injected with 10 μL of C.auris strain TDG1912 at 1 × 107 CFU/mL into the first left proleg[1]
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Dosage:10, 20, 50 mg/kg
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Administration:Local injected once after infection 30 min
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Result:Demonstrated significant antifungal efficacy at 50 mg/kg and 20 mg/kg doses.
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Animal Model:D.melaogaster adults were injected with 10 nL of C.auris strain TDG1912 at a concentration of 2 × 1011 CFU/mL or 1 × 1012 CFU/mL into the dorsolateral thorax below the right wing hinge[1]
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Dosage:5, 20, 50 mg/kg
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Administration:Local injected once after infection 1 h
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Result:Improved survival at both 50 and 20 mg/kg compared to the untreated group.
Chemical Information
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Molecular Weight 433.43
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Formula C20H22F3N7O
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SMILES
OC(C1=CC=C(C=C1F)F)(CN2CCC(CC2)NC3=NC=C(C=N3)F)CN4N=CN=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CYP51-IN-26 Related Classifications
HY-174973 Related Classifications
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