Voriconazole (Synonyms: UK-109496)

Name: Voriconazole
Brand: MedChemExpress
SKU: HY-76200
Rating: 5.0 (11 reviews)

Cat. No.: HY-76200 Purity: 99.45%: Data Sheet
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Voriconazole (UK-109496) is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes. Voriconazole can penetrate the blood brain barrier (BBB).

For research use only. We do not sell to patients.

CAS No. : 137234-62-9

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
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Customer Review

Based on 11 publication(s) in Google Scholar

Other Forms of Voriconazole:

11 Publications Citing Use of MCE Voriconazole

Others

In Vivo Efficacy Study

Microbiological Assay

Cell Imaging/Staining

: Voriconazole purchased from MedChemExpress. Usage Cited in: BMC Microbiol. 2025 Nov 5;25(1):715. [Abstract]; Interaction profile of REV combined with ITR, Voriconazole and POS against Aspergillus spp.

: Voriconazole purchased from MedChemExpress. Usage Cited in: Microbiol Spectr. 2025 Mar 31:e0318524. [Abstract]; MIC values of antifungal drugs (Voriconazole) against CT27.

: Voriconazole purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Oct 14:2025.10.13.682145.; Experimental design for HSPC mobilization. Wild-type C57BL/6J or Townes SCD mice were treated with Voriconazole (50 mg/kg/day, iv) or vehicle intravenously daily for four days, followed by AMD3100 or vehicle one hour before peripheral blood collection for CFU assays.

: Voriconazole purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Oct 14:2025.10.13.682145.; Experimental design for HSPC mobilization. Wild-type C57BL/6J or Townes SCD mice were treated with Voriconazole (50 mg/kg/day, iv) or vehicle intravenously daily for four days, followed by AMD3100 or vehicle one hour before peripheral blood collection for CFU assays. Numbers of CFU-C in peripheral blood of C57BL/6J mice after the indicated treatments.

: Voriconazole purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Oct 14:2025.10.13.682145.; Experimental design for HSPC mobilization. Wild-type C57BL/6J or Townes SCD mice were treated withVvoriconazole (50 mg/kg/day, iv) or vehicle intravenously daily for four days, followed by AMD3100 or vehicle one hour before peripheral blood collection for CFU assays. Numbers of CFU-gmEM (C) in peripheral blood of C57BL/6J mice after the indicated treatments.

: Voriconazole purchased from MedChemExpress. Usage Cited in: Front Cell Infect Microbiol. 2020 Jun 26;10:320. [Abstract]; Kaplan-Meier survival plots of C. elegans infected by KU80Δ in the presence of antifungal drugs. The glp-4(bn2); sek-1(km4) worms were pre-infected with KU80Δ for 8 h then transferred into liquid killing media containing different concentrations of Voriconazole (0-1.5 μg/mL).

: Voriconazole purchased from MedChemExpress. Usage Cited in: Front Cell Infect Microbiol. 2020 Jun 26;10:320. [Abstract]; Effect of antifungal treatment on Af293-dsRed infection to glp-4(bn2); sek-1(km4) worms. Images were taken under DIC and TRITC channels from DMSO treatment by 24 h, 1.5 μg/ml AmB treatment by 48 h, 2 μg/ml ItrZ treatment by 72 h and 0.5 μg/ml Voriconazole treatment by 72 h. Scale bar is 200 μm.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	> 30 μM Compound: VOR	Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay	[PMID: 34388384]
CHO	IC₅₀	414.2 μM Compound: voriconazole	Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunits Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunits	[PMID: 23812503]
CHO	IC₅₀	> 40 μM Compound: 3	Inhibition of human ERG expressed in CHO cells by whole-cell patch clamp assay Inhibition of human ERG expressed in CHO cells by whole-cell patch clamp assay	[PMID: 24564525]
Hepatocyte	IC₅₀	13 μM Compound: Voriconazole	Inhibition of CYP3A4 in human hepatocytes using testosterone as substrate by HPLC/MS/MS method Inhibition of CYP3A4 in human hepatocytes using testosterone as substrate by HPLC/MS/MS method	[PMID: 24948565]
MCF7	IC₅₀	> 30 μM Compound: VOR	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay	[PMID: 34388384]
MRC5	IC₅₀	40 μg/mL Compound: VOR	Cytotoxicity against human MRC5 cells after 48 hrs by MTT assay Cytotoxicity against human MRC5 cells after 48 hrs by MTT assay	[PMID: 26867487]
MRC5	IC₅₀	40 μg/mL Compound: Voriconazole	Cytotoxicity against human MRC5 cells after 48 hrs by MTT assay Cytotoxicity against human MRC5 cells after 48 hrs by MTT assay	[PMID: 26586600]
THLE-2	IC₅₀	> 30 μM Compound: VOR	Cytotoxicity against human THLE-2 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay Cytotoxicity against human THLE-2 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay	[PMID: 34388384]

In Vitro

Voriconazole has great activity against S. apiospermum and C. neoformans with the MICs of 0.5 μg/mL and 0.125-0.25 μg/mL, respectively^[1].
Voriconazole inhibits the cytochrome P450 (CYP)-dependent enzyme 14-alpha-sterol demethylase, thereby disrupting the cell membrane and halting fungal growth^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Voriconazole (5-20 mg/kg; p.o. for 21 days) prolongs survival in a dose-dependent fashion. Voriconazole (40 mg/kg/day) decreases the fungal burden in the lungs^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male specific-pathogen-free BALB/cByJ mice^[3]
Dosage:	1, 5, 20 mg/kg/day
Administration:	P.o. once daily for 21 days
Result:	Improved survival in a dose-response fashion, with median survival times (MSTs) of 21, 28, and 35 days with doses of 1, 5, and 20 mg/kg, respectively.

Molecular Weight

349.31

Formula

C₁₆H₁₄F₃N₅O

CAS No.

137234-62-9

Appearance

Solid

Color

White to off-white

SMILES

O[C@@](CN1N=CN=C1)(C2=CC=C(F)C=C2F)[C@H](C3=NC=NC=C3F)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	1 year
	-20°C	6 months

Solvent & Solubility

In Vitro:

DMSO : ≥ 50 mg/mL (143.14 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 0.17 mg/mL (0.49 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8628 mL	14.3139 mL	28.6279 mL
5 mM	0.5726 mL	2.8628 mL	5.7256 mL
10 mM	0.2863 mL	1.4314 mL	2.8628 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.16 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (7.16 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (7.16 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.89%

Select Batch:

Data Sheet (278 KB) SDS (393 KB)

COA (256 KB) LCMS (264 KB)

Handling Instructions (2659 KB)

References

[1]. Nickie D Greer, et al. Voriconazole: the newest triazole antifungal agent.Proc (Bayl Univ Med Cent). 2003 Apr;16(2):241-8. [Content Brief]

[2]. Michael E Henry, et al. Quantification of brain voriconazole levels in healthy adults using fluorine magnetic resonance spectroscopy. Antimicrob Agents Chemother. 2013 Nov;57(11):5271-6. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.8628 mL	14.3139 mL	28.6279 mL	71.5697 mL
	5 mM	0.5726 mL	2.8628 mL	5.7256 mL	14.3139 mL
	10 mM	0.2863 mL	1.4314 mL	2.8628 mL	7.1570 mL
	15 mM	0.1909 mL	0.9543 mL	1.9085 mL	4.7713 mL
	20 mM	0.1431 mL	0.7157 mL	1.4314 mL	3.5785 mL
	25 mM	0.1145 mL	0.5726 mL	1.1451 mL	2.8628 mL
	30 mM	0.0954 mL	0.4771 mL	0.9543 mL	2.3857 mL
	40 mM	0.0716 mL	0.3578 mL	0.7157 mL	1.7892 mL
	50 mM	0.0573 mL	0.2863 mL	0.5726 mL	1.4314 mL
	60 mM	0.0477 mL	0.2386 mL	0.4771 mL	1.1928 mL
	80 mM	0.0358 mL	0.1789 mL	0.3578 mL	0.8946 mL
	100 mM	0.0286 mL	0.1431 mL	0.2863 mL	0.7157 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Voriconazole Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Voriconazole137234-62-9UK-109496UK109496UK 109496FungalBacterialbroad-spectrumtriazoleantifungalmurinepulmonaryblastomycosisInhibitorinhibitorinhibit

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Voriconazole (Synonyms: UK-109496)

Customer Review

Other Forms of Voriconazole:

Voriconazole Related Antibodies

11 Publications Citing Use of MCE Voriconazole

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•Related Small Molecules:

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Biological Activity

Purity & Documentation

References

Customer Review

Voriconazole Related Antibodies

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Complete Stock Solution Preparation Table

Voriconazole Related Classifications

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