1. Anti-infection
  2. Fungal
  3. Voriconazole

Voriconazole (Synonyms: UK-109496)

Cat. No.: HY-76200 Purity: 99.97%
Handling Instructions

Voriconazole (UK-109496) is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes.

For research use only. We do not sell to patients.

Voriconazole Chemical Structure

Voriconazole Chemical Structure

CAS No. : 137234-62-9

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10 mM * 1 mL in DMSO USD 117 In-stock
Estimated Time of Arrival: December 31
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100 mg USD 138 In-stock
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Based on 4 publication(s) in Google Scholar

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Description

Voriconazole (UK-109496) is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes[1][2].

In Vitro

Voriconazole has great activity against S. apiospermum and C. neoformans with the MICs of 0.5 μg/mL and 0.125–0.25 μg/mL, respectively[1].
Voriconazole inhibits the cytochrome P450 (CYP)-dependent enzyme 14-alpha-sterol demethylase, thereby disrupting the cell membrane and halting fungal growth[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Voriconazole (5-20 mg/kg; p.o. for 21 days) prolongs survival in a dose-dependent fashion. Voriconazole (40 mg/kg/day) decreases the fungal burden in the lungs[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male specific-pathogen-free BALB/cByJ mice[3]
Dosage: 1, 5, 20 mg/kg/day
Administration: P.o. once daily for 21 days
Result: Improved survival in a dose-response fashion, with median survival times (MSTs) of 21, 28, and 35 days with doses of 1, 5, and 20 mg/kg, respectively.
Clinical Trial
Molecular Weight

349.31

Formula

C16H14F3N5O

CAS No.
SMILES

O[[email protected]@]([[email protected]@H](C)C1=NC=NC=C1F)(CN2N=CN=C2)C(C(F)=C3)=CC=C3F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (143.14 mM)

H2O : 0.17 mg/mL (0.49 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8628 mL 14.3139 mL 28.6279 mL
5 mM 0.5726 mL 2.8628 mL 5.7256 mL
10 mM 0.2863 mL 1.4314 mL 2.8628 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.16 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.16 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.16 mM); Clear solution

*All of the co-solvents are available by MCE.
References

Purity: 99.97%

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Product Name:
Voriconazole
Cat. No.:
HY-76200
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