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Cat. No.: HY-175304

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DMU371

DMU371 is a Trypanosoma cruzi lysyl-tRNA synthetase 1 (KRS1) inhibitor (IC₅₀=185 nM). DMU371 is promising for research of infectious diseases.

For research use only. We do not sell to patients.

CAS No.: 3052352-34-5
Formula: C₁₄H₁₅F₃N₄
Molecular Weight:296.29

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

DMU371 Chemical Structure

CAS No.: 3052352-34-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

DMU371 is a Trypanosoma cruzi lysyl-tRNA synthetase 1 (KRS1) inhibitor (IC₅₀=185 nM). DMU371 is promising for research of infectious diseases^[1].

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Chemical Information

CAS No. 3052352-34-5
Molecular Weight 296.29
Formula C₁₄H₁₅F₃N₄
SMILES

NC1=C2C(F)=C(F)C(NC3CCCC3)=C(F)C2=NC(C)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Tulloch LB, et al. Antitrypanosomal quinazolines targeting lysyl-tRNA synthetase show partial efficacy in a mouse model of acute Chagas disease. Sci Transl Med. 2025 Jul 9;17(806):eadu4564. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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