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Art. -Nr.: HY-175343

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OICR-41103

OICR-41103 is a selective DCAF1 WDR domain binder with K_d <2 nM. OICR-41103 has no effect on the p53/MDM2 protein-protein interaction. OICR-41103 can be used for HIV research.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₂₈H₂₆Cl₂F₂N₄O₃
Molecular Weight:575.43

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

OICR-41103 Chemical Structure

Größe

Preis

Verfügbarkeit

Menge

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

OICR-41103 is a selective DCAF1 WDR domain binder with K_d <2 nM. OICR-41103 has no effect on the p53/MDM2 protein-protein interaction. OICR-41103 can be used for HIV research^[1]^[2].

IC₅₀ & Target

^[2]

DCAF1

<2 nM (Kd)

Alle Ligands for E3 Ligase Isoform-spezifische Produkte anzeigen :

Alle HIV Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
NCI-H460	EC50	165 nM	Thermal stabilization of Flag-HiBiT-tagged DCAF1 WDR domain in NCI-H460 cells after 3 hrs incubation measured by cellular thermal shift assay with luminescence readout. Thermal stabilization of Flag-HiBiT-tagged DCAF1 WDR domain in NCI-H460 cells after 3 hrs incubation measured by cellular thermal shift assay with luminescence readout.	40683980
HEK-293T	EC50	128 nM	Displacement of DCAF1 tracer in HEK293T cells expressing NanoLuc-tagged DCAF1 WDR domain after 1 hr incubation measured by NanoBRET. Displacement of DCAF1 tracer in HEK293T cells expressing NanoLuc-tagged DCAF1 WDR domain after 1 hr incubation measured by NanoBRET.	40683980

In Vitro

Anti-cancerOthers

Anti-cancer

OICR-41103 (7 days) does not inhibit the growth of NCI-H1703, NCI-H1915, or NCI-H2170 NSCLC cells within 7 days^[2].
OICR-41103 (up to 3 µM; 5 days) does not affect the confluence of HEK293T, MCF7, U2OS, or HCT116 cells at up to 3 µM within 5 days^[2].

Others

OICR-41103 (up to 15.625 µM) binds the DCAF1 WDR domain with a K_D below 2 nM^[2].
OICR-41103 (20 µM) has a thermal stabilizing effect on the DCAF1 WDR domain, with a maximum ΔTm of 23.0 °C at 20 µM^[2].
OICR-41103 (up to 20 µM) shows no significant binding to WDR61, WDR92, WDR5, DDB1, FBXW7, or PAFAH1B1 at concentrations up to 20 µM^[2].
OICR-41103 (3 h) exerts a thermal stabilizing effect on the DCAF1 WDR domain in NCI-H460 cells, with an EC₅₀ of 165 nM^[2].
OICR-41103 (1 h) displaces the DCAF1 tracer with an EC₅₀ of 128 nM in HEK293T cells^[2].
OICR-41103 (3 h) disrupts the DCAF1 WDR-Vpr interaction in HEK293EMT cells with an EC₅₀ of 1 µM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[2]

Cell Line:

HEK293T, MCF7, U2OS, and HCT116 cells
Concentration:

Up to 3 µM
Incubation Time:

5 days (topped up after 3 days)
Result:

Cell confluency was not affected in HEK293T, MCF7, U2OS, or HCT116 cells up to 3 µM over 5 days.

Related Protocols :

Chemical Information

Molecular Weight 575.43
Formel C₂₈H₂₆Cl₂F₂N₄O₃
SMILES

NC(C[C@@H](C1=CC=C(C(Cl)=C1)F)NC(C2=CNC(/C=C/C(N3CCCCC3)=O)=C2C4=C(C=C(C=C4)Cl)F)=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Reber V. Decoding non-catalytic mechanisms of small molecule-protein interactions[D]. ETH Zurich, 2026.

[2]. Kimani SW, et al. OICR-41103 as a chemical probe for the DCAF1 WD40 domain. Communications biology. 2025 Jul 19;8(1):1076. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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OICR-41103

Alle Ligands for E3 Ligase Isoform-spezifische Produkte anzeigen

Alle HIV Isoform-spezifische Produkte anzeigen