2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P991026
    Sonesitatug 2883771-43-3 98.604%
    HY-P991026 is an CLDN18-targeting IgG1κ type humanized antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001).
    Sonesitatug
  • HY-P991146
    Lecankitug 2923284-76-6 98%
    Lecankitug is a humanized monoclonal antibody targeting human interleukin 17A (IL-17A) and interleukin 17F (IL-17F). Lecankitug specifically binds to IL-17A and IL-17F, blocking their signal transduction, thus exerting immunosuppressive and anti-inflammatory activities. Lecankitug is promising for research of autoimmune and inflammatory diseases, such as psoriasis and rheumatoid arthritis.
    Lecankitug
  • HY-P991401
    GSK2862277
    GSK2862277 is a human monoclonal antibody (mAb) targeting TNFRSF1A. GSK2862277 increases neutrophil extracellular trap formation and alveolar macrophage phagocytosis. GSK2862277 can be used in Acute lung injury and Acute Respiratory Distress Syndrome (ARDS) research. Recommended isotype control: VHH-hFc.
    GSK2862277
  • HY-P991454
    Anti-LGR5/GPR49 Antibody (18G7H6A3) 98.64%
    Anti-LGR5/GPR49 Antibody (18G7H6A3) is a human monoclonal antibody (mAb) targeting LGR5/GPR49. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).
    Anti-LGR5/GPR49 Antibody (18G7H6A3)
  • HY-P991455
    PTX-35 98.95%
    PTX-35 is a costimulatory agonist antibody targeting TNFRSF25 as well as an immune activator that selectively regulates activated CD8+ T cells. PTX-35 enhances the expansion, survival and effector functions of T cells, while reducing the inhibitory activity of regulatory T cells and impairing their stability. PTX-35 exhibits anti-tumor activity, effectively delaying tumor progression and prolonging survival. PTX-35 has a synergistic effect with anti-OX40 agonist antibodies. PTX-35 can be widely used in research on related diseases such as colon cancer and melanoma.
    PTX-35
  • HY-P991513
    BI-655064 98.56%
    BI-655064, a humanised anti-CD40 antibody with has fragment crystallisable (Fc) regions with two mutations that prevent Fc-mediated antibody-dependent or complement-mediated cellular cytotoxicity and platelet activation. BI-655064 can be used for the study of autoimmune disease, such as lupus nephritis and rheumatoid arthritis (RA).
    BI-655064
  • HY-P991611
    ART5803 3058434-76-4 98.64%
    ART5803 is a humanized IgG1 monoclonal antibody inhibitor targeting NMDAR. ART5803 binds to the N-terminal domain (NTD) of the NMDAR GluN1 subunit (GluN1-NTD) with a high affinity. ART5803 blocks NMDAR internalization induced by pathogenic autoantibodies and restores cell-surface NMDAR expression and functions. ART5803 reverses behavioral abnormalities and NMDAR expression in marmoset disease models. ABT-147 can be used to study anti-NMDAR encephalitis.
    ART5803
  • HY-P991828
    Anti-Mouse IL-2 Antibody (JES6-5H4) 98.62%
    Anti-Mouse IL-2 Antibody (JES6-5H4) reacts with mouse IL-2 that can neutralize IL-2 in vivo. Recommend Isotype Controls: Rat IgG2b kappa, Isotype Control (HY-P990682).
    Anti-Mouse IL-2 Antibody (JES6-5H4)
  • HY-P9S0056
    Human IgG1 (L234A/L235A) lambda2, Isotype Control
    Human IgG1 (L234A/L235A) lambda2, Isotype Control, is a human monoclonal antibody that serves as an isotype control for human IgG1λ antibody.
    Human IgG1 (L234A/L235A) lambda2, Isotype Control
  • HY-W009304
    Methylarbutin 6032-32-2
    Methylarbutin exhibits anti-inflammatory and urinary antiseptic activity.
    Methylarbutin
  • HY-W009688
    Dibutyl maleate 105-76-0 99.19%
    Dibutyl maleate, the diester of the Maleic Acid, can be used as an intermediate of pharmaceutical synthesis. Dibutyl maleate can enhance contact sensitization to Fluorescein isothiocyanate in mice.
    Dibutyl maleate
  • HY-W011400
    TLR1 566914-00-9 ≥99.0%
    TLR1 (compound 4a) is a low molecular weight, cell-penetrating Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop mimic. TLR1 inhibits IL-1 receptor-mediated responses.
    TLR1
  • HY-W011434
    Triglycidyl isocyanurate 2451-62-9 99.56%
    Triglycidyl isocyanurate (TGIC; Teroxirone) is a triazene triepoxide with antiangiogenic and antineoplastic activities. Triglycidyl isocyanurate inhibits the growth of non-small-cell-lung cancer cells via?p53 activation. Triglycidyl isocyanurate induces cell apoptosis. Triglycidyl isocyanurate can be used for cancer research.
    Triglycidyl isocyanurate
  • HY-W062696
    BC-1382 1013753-99-5 99.36%
    BC-1382 is a potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction (IC50≈ 5 nM).Anti-inflammatory activity.
    BC-1382
  • HY-W088191
    4-Hydroxybenzamide 619-57-8 99.83%
    4-Hydroxybenzamide is an amide and intermediate. 4-Hydroxybenzamide can be isolated from the herb Berberis pruinosa. 4-Hydroxybenzamide derivatives exhibit anti-breast cancer activity. 4-Hydroxybenzamide can be used in atherosclerosis research.
    4-Hydroxybenzamide
  • HY-W127841
    Citric acid-2,4-13C2 121633-50-9 98.00%
    Citric acid-2,4-13C2 is the 13C-labeled Citric acid (HY-N1428). Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries.
    Citric acid-2,4-13C2
  • HY-W129596
    Policresulen 101418-00-2
    Policresulen is a competitive inhibitor for DENV2 NS2B/NS3 protease with an IC50 of 0.48 μg/mL. Policresulen can be used as a local hemostatic and antibacterial agent for research of cervical and vaginal inflammation, skin lesions, oral mucosa and gingival inflammation.
    Policresulen
  • HY-W272217
    Octacosane 630-02-4 ≥98.0%
    Octacosane is an endogenous metabolite with antibacterial activity. Octacosane shows high cytotoxicity against murine melanoma B16F10-Nex2 cells besides inducing protection against a grafted subcutaneous melanoma. Octacosane has the larvicidal activity against mosquito Culex quinquefasciatus with the LC50 concentration of 7.2 mg/l.
    Octacosane
  • HY-W283930
    YHV98-4 132858-26-5 98.26%
    YHV98-4 is a selective, blood-brain barrier permeable Hv1 channel inhibitor. YHV98-4 specifically inhibits Hv1 with a half-maximal inhibitory concentration of 1 µM without inhibiting other ion channels. YHV98-4 reduces the propagation of p-tau. YHV98-4 increases ATP production, and enhances microglial mitophagy. YHV98-4 attenuates inflammatory pain via inhibition of Hv1 and ROS production. YHV98-4 enhances microglia-to-neuron mitochondrial transfer, promoting the delivery of functional mitochondria to rescue neuronal damage and improve cognitive function. YHV98-4 reduces inflammation. YHV98-4 can be used in the research of Alzheimer's disease.
    YHV98-4
  • HY-W322573
    (R)-Ketoprofen 56105-81-8
    (R)-Ketoprofen is an orally active nonsteroidal anti-inflammatory drug (NSAID) with analgesic properties. (R)-Ketoprofen does not significantly amplify the increase of inflammatory cytokines (such as tumor necrosis factor (TNF) and interleukin-1 (IL-1)) induced by LPS, but it can inhibit the anti-inflammatory activity of (S)-Ketoprofen.
    (R)-Ketoprofen
Cat. No. Product Name / Synonyms Application Reactivity