2. Apoptosis
  3. MDM-2/p53 Apoptosis
  4. Triglycidyl isocyanurate

Triglycidyl isocyanurate  (Synonyms: TGIC; Teroxirone)

Cat. No.: HY-W011434 Purity: ≥98.0%
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Triglycidyl isocyanurate (TGIC; Teroxirone) is a triazene triepoxide with antiangiogenic and antineoplastic activities. Triglycidyl isocyanurate inhibits the growth of non-small-cell-lung cancer cells via p53 activation. Triglycidyl isocyanurate induces cell apoptosis. Triglycidyl isocyanurate can be used for cancer research.

For research use only. We do not sell to patients.

Triglycidyl isocyanurate Chemical Structure

Triglycidyl isocyanurate Chemical Structure

CAS No. : 2451-62-9

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10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

Triglycidyl isocyanurate Related Antibodies

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Description

Triglycidyl isocyanurate (TGIC; Teroxirone) is a triazene triepoxide with antiangiogenic and antineoplastic activities. Triglycidyl isocyanurate inhibits the growth of non-small-cell-lung cancer cells via p53 activation. Triglycidyl isocyanurate induces cell apoptosis. Triglycidyl isocyanurate can be used for cancer research[1][2].

In Vitro

Triglycidyl isocyanurate (0-30 μM; 48 hours) reduces the growth of spheroids of human non-small-cell-lung cancer cells in culture, it leads to a gradual reduction in size for tumorspheres of A549, H460 and H1299 cells[1].
Triglycidyl isocyanurate (0-30 μM; 48 hours) inhibits expression of akt1/2/3 and phosphorylated Aktser473/474/472 of A549, H460 and H1299 tumorspheres, however, the cleavage of PARP and procaspase-3 plus the emergent active caspase-3 fragment are only visible in H460 and A549 tumorspheres[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Triglycidyl isocyanurate Related Antibodies

Cell Viability Assay[1]

Cell Line: A549, H460 and H1299 cells
Concentration: 0 μM; 5 μM; 10 μM; 30 μM
Incubation Time: 48 hours
Result: Inhibited tumor cells growth in soft agar.

Western Blot Analysis[1]

Cell Line: A549, H460 and H1299 cells
Concentration: 0 μM; 5 μM; 10 μM; 30 μM
Incubation Time: 48 hours
Result: Inhibited akt1/2/3 expression and p-aktser473/474/472 expression of A549, H460 and H1299 tumorspheres
In Vivo

Triglycidyl isocyanurate (subcutaneous injection; 1.8 and 3.6 mg/kg; every 2–3 days for total seven times; 30 days) suppresses the growth of xenograft tumors and has no effects on weight in nude mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female nu/nu mice with Huh7 cells subcutaneously injected into the dorsal area[2]
Dosage: 1.8 mg/kg and 3.6 mg/kg
Administration: Subcutaneous injection; every 2–3 days for total seven times; 30 days
Result: Inhibited the growth of xenograft tumors.
Molecular Weight

297.26

Formula

C12H15N3O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N(C1=O)CC2CO2)N(C(N1CC3CO3)=O)CC4CO4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (168.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3641 mL 16.8203 mL 33.6406 mL
5 mM 0.6728 mL 3.3641 mL 6.7281 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3641 mL 16.8203 mL 33.6406 mL 84.1015 mL
5 mM 0.6728 mL 3.3641 mL 6.7281 mL 16.8203 mL
10 mM 0.3364 mL 1.6820 mL 3.3641 mL 8.4101 mL
15 mM 0.2243 mL 1.1214 mL 2.2427 mL 5.6068 mL
20 mM 0.1682 mL 0.8410 mL 1.6820 mL 4.2051 mL
25 mM 0.1346 mL 0.6728 mL 1.3456 mL 3.3641 mL
30 mM 0.1121 mL 0.5607 mL 1.1214 mL 2.8034 mL
40 mM 0.0841 mL 0.4205 mL 0.8410 mL 2.1025 mL
50 mM 0.0673 mL 0.3364 mL 0.6728 mL 1.6820 mL
60 mM 0.0561 mL 0.2803 mL 0.5607 mL 1.4017 mL
80 mM 0.0421 mL 0.2103 mL 0.4205 mL 1.0513 mL
100 mM 0.0336 mL 0.1682 mL 0.3364 mL 0.8410 mL
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Triglycidyl isocyanurate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Triglycidyl isocyanurate2451-62-9TGIC TeroxironeMDM-2/p53Apoptosisanticancer agentNSCLChepatocellularcarcinomaHCCtumorHepG2Hep3Bliver cancerInhibitorinhibitorinhibit

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