Triglycidyl isocyanurate
Based on 1 Customer Validation
Triglycidyl isocyanurate (TGIC; Teroxirone) is a triazene triepoxide with antiangiogenic and antineoplastic activities. Triglycidyl isocyanurate inhibits the growth of non-small-cell-lung cancer cells via?p53 activation. Triglycidyl isocyanurate induces cell apoptosis. Triglycidyl isocyanurate can be used for cancer research.
For research use only. We do not sell to patients.
- Purity: 99.56%
- CAS No.: 2451-62-9
- Formula: C12H15N3O6
- Molecular Weight:297.26
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Triglycidyl isocyanurate?(0-30 μM; 48?hours) reduces the growth of spheroids of human non-small-cell-lung cancer cells in culture, it leads to a gradual reduction in size for tumorspheres of A549, H460 and H1299 cells[1].Triglycidyl isocyanurate (0-30 μM; 48?hours) inhibits expression of akt1/2/3 and phosphorylated Aktser473/474/472?of A549, H460 and H1299 tumorspheres, however, the?cleavage?of PARP and?procaspase-3?plus the emergent active?caspase-3?fragment are only visible in H460 and A549 tumorspheres[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549, H460 and H1299 cells
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Concentration:0 μM; 5 μM; 10 μM; 30 μM
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Incubation Time:48 hours
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Result:Inhibited tumor cells growth in soft agar.
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Cell Line:A549, H460 and H1299 cells
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Concentration:0 μM; 5 μM; 10 μM; 30 μM
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Incubation Time:48 hours
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Result:Inhibited akt1/2/3 expression and p-aktser473/474/472 expression of A549, H460 and H1299 tumorspheres
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female nu/nu mice with Huh7 cells subcutaneously injected into the dorsal area[2]
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Dosage:1.8 mg/kg and 3.6 mg/kg
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Administration:Subcutaneous injection; every 2–3 days for total seven times; 30 days
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Result:Inhibited the growth of xenograft tumors.
Chemical Information
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CAS No. 2451-62-9
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Appearance Solid
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Molecular Weight 297.26
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Formula C12H15N3O6
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Color White to off-white
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SMILES
O=C(N(C1=O)CC2CO2)N(C(N1CC3CO3)=O)CC4CO4
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Synonyms
TGIC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
DMSO : 50 mg/mL (168.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (805 KB)
- English - EN (805 KB)
- Français - FR (805 KB)
- Deutsch - DE (805 KB)
- Norwegian - NO (805 KB)
- Español - ES (805 KB)
- Swedish - SV (805 KB)
- Italian - IT (805 KB)
- Korean - KR (805 KB)
- Portuguese - PT (805 KB)
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Handling Instructions (2659 KB)
References
[1]. Yu-Ling Ni, et al. Teroxirone motivates apoptotic death in tumorspheres of human lung cancer cells. Chem Biol Interact. 2018 Aug 1;291:137-143 [Content Brief]
[2]. Seung-Hun Kim, et al. Teroxirone suppresses growth and motility of human hepatocellular carcinoma cells.Biomed Pharmacother. 2018 Mar;99:997-1008 [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3641 mL | 16.8203 mL | 33.6406 mL | 84.1015 mL |
| 5 mM | 0.6728 mL | 3.3641 mL | 6.7281 mL | 16.8203 mL | |
| 10 mM | 0.3364 mL | 1.6820 mL | 3.3641 mL | 8.4101 mL | |
| 15 mM | 0.2243 mL | 1.1214 mL | 2.2427 mL | 5.6068 mL | |
| 20 mM | 0.1682 mL | 0.8410 mL | 1.6820 mL | 4.2051 mL | |
| 25 mM | 0.1346 mL | 0.6728 mL | 1.3456 mL | 3.3641 mL | |
| 30 mM | 0.1121 mL | 0.5607 mL | 1.1214 mL | 2.8034 mL | |
| 40 mM | 0.0841 mL | 0.4205 mL | 0.8410 mL | 2.1025 mL | |
| 50 mM | 0.0673 mL | 0.3364 mL | 0.6728 mL | 1.6820 mL | |
| 60 mM | 0.0561 mL | 0.2803 mL | 0.5607 mL | 1.4017 mL | |
| 80 mM | 0.0421 mL | 0.2103 mL | 0.4205 mL | 1.0513 mL | |
| 100 mM | 0.0336 mL | 0.1682 mL | 0.3364 mL | 0.8410 mL |
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