Lecankitug
Based on 1 Customer Validation
Lecankitug is a humanized monoclonal antibody targeting human interleukin 17A (IL-17A) and interleukin 17F (IL-17F). Lecankitug specifically binds to IL-17A and IL-17F, blocking their signal transduction, thus exerting immunosuppressive and anti-inflammatory activities. Lecankitug is promising for research of autoimmune and inflammatory diseases, such as psoriasis and rheumatoid arthritis.
For research use only. We do not sell to patients.
- Purity: 98%
- CAS No.: 2923284-76-6
- Molecular Weight:146.514 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Human IgG1 kappa
Human
|
IL-17A |
IL-17F |
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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IgG1-kappa
ELISA, FACS, Functional assay
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Loaded Lecankitug on ProA biosensor, can bind HY-P70527 IL-17A Protein, Human (HEK293, His) with an affinity constant of 3.464E-10 M as determined in BLI assay. -
Loaded Lecankitug on ProA biosensor, can bind HY-P72586 IL-17F Protein, Human (HEK293) with an affinity constant of 1.853E-09 M as determined in BLI assay.
Chemical Information
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CAS No. 2923284-76-6
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Appearance Liquid
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Molecular Weight 146.514 kDa
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Color Colorless to light yellow
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SMILES
N/A
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Synonyms
LZM-012; XKH004
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (255 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)