Lecankitug
Based on 1 Customer Validation
Lecankitug (LZM-012) is a humanized IgG1κ monoclonal antibody targeting IL-17A/F. Lecankitug exerts immunosuppressive and anti-inflammatory activities. Lecankitug can be used in the research of autoimmune and inflammatory diseases, such as psoriasis, ankylosing spondylitis, and rheumatoid arthritis.
For research use only. We do not sell to patients.
- Purity: 98%
- CAS No.: 2923284-76-6
- Molecular Weight:146.514 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Human IgG1 kappa
Human
|
IL-17A |
IL-17F |
IL-17A/F are proinflammatory cytokines involved in the pathological processes of autoimmune diseases such as psoriasis and ankylosing spondylitis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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IgG1-kappa
ELISA, FACS, Functional assay
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Loaded Lecankitug on ProA biosensor, can bind HY-P70527 IL-17A Protein, Human (HEK293, His) with an affinity constant of 3.464E-10 M as determined in BLI assay. -
Loaded Lecankitug on ProA biosensor, can bind HY-P72586 IL-17F Protein, Human (HEK293) with an affinity constant of 1.853E-09 M as determined in BLI assay.
Chemical Information
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CAS No. 2923284-76-6
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Appearance Liquid
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Molecular Weight 146.514 kDa
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Color Colorless to light yellow
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SMILES
N/A
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Synonyms
LZM-012; XKH004
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (256 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)