2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W782446
    Dimethyl sulfoxide-13C2 136321-15-8 98%
    Dimethyl sulfoxide-13C2 (DMSO-13C2) is the 13C-labeled Dimethyl sulfoxide (HY-Y0320C). Dimethyl sulfoxide (DMSO) is an aprotic solvent that can dissolve water-insoluble therapeutic and toxic agents. Dimethyl sulfoxide (DMSO) has a strong affinity for water and has the ability to rapidly penetrate or enhance the penetration of?other?substances through biological membranes. Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity. Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity.
    Dimethyl sulfoxide-13C2
  • HY-W782935
    MAPKAPK5-IN-1 1195065-29-2 98%
    MAPKAPK5-IN-1 is a substitutedtriazolopyrazine or imidazopyrazine compound and MAPKAPK5 inhibitor.MAPKAPK5-IN-1 can be used for the research of rheumatoid arthritis.
    MAPKAPK5-IN-1
  • HY-W783478
    Calebin A 336784-82-8 98.00%
    Calebin A is a PI3K/Akt/mTOR, MAPK, and NF-κB inhibitor with oral effectiveness. Calebin A can block the autophagy-repressive, inhibiting apoptosis. Calebin A has anti-tumor activity by epigenetic regulation. Calebin A suppresses adipogenesis, modulates thermogenesis, and enriches gut probiotics. Calebin A can be used in research on osteoarthritis, Alzheimer's disease, type 2 diabetes, malignant peripheral nerve sheath tumors, and colorectal cancer.
    Calebin A
  • HY-W794609
    Pinocarveol 5947-36-4 98.38%
    Pinocarveol is a monoterpene found in Pistacia atlantica subsp. kurdica hulls’ essential oil. Pinocarveol exhibits antioxidant and antibacterial activities.
    Pinocarveol
  • HY-W795993
    TJU103 10245-44-0 98%
    TJU103 is a CD4 inhibitor. TJU103 inhibits autoreactive CD4+ T cells by disrupting the function of the CD4 during activation. TJU103 decreases mononuclear cell infiltration in brain and spinal cord tissue of experimental allergic encephalomyelitis (EAE) mice model. TJU103 downregulates Th1 and Th2 cytokine levels in response to proteolipid protein epitope 139-151 (PLPe) and exhibits inhibitory effects both after the appearance of EAE symptoms and upon rechallenge with Ag. TJU103 can be used for autoimmune diseases like EAE and sclerosis (MS) research.
    TJU103
  • HY-W800535
    Cryptolepine 480-26-2 98%
    Cryptolepine is an orally active multi-potent alkaloid with anti-cancer, anti-bacterial, anti-viral, anti-malarial, anti-inflammatory, anti-hyperglycemic, relieve pain and other properties. Cryptolepine acts as an inhibitor of c-Myc, mTOR, NF-κB, HIF-1, MAPK and an activator of AMPKα1/2. It intercalates into DNA, inhibits topoisomerase II (Top II), disrupts mitochondrial dynamics and induces apoptosis. Cryptolepine also exhibits anti-plasmodial and cholinesterase inhibitory activities. Cryptolepine can be used in research related to tumors (melanoma, hepatocellular carcinoma, mammary adenocarcinoma, etc.), malaria, inflammatory diseases and diabetes, particularly in studies focused on inhibiting tumor growth and anti-plasmodial infection.
    Cryptolepine
  • HY-W838171
    Tiaramide 32527-55-2
    Tiaramide is an anti-inflammatory agent. Tiaramide inhibits the PGE2 release. Tiaramide inhibits the rise in intracellular free Ca2+ induced by PGE2 (HY-101952) as well as Bradykinin (HY-P0206). Tiaramide inhibites Bradykinin-induced contraction.
    Tiaramide
  • HY-W840250
    3,5-Dimethyl-4-phenylisoxazole 4345-46-4 98%
    3,5-Dimethyl-4-phenylisoxazole (3,5-Dimethyl-4-phenyl-1,2-oxazole) is a heterocyclic compound that serves as a molecular structural unit, exhibiting anti-inflammatory, anti-tumor, anti-bacterial, and anti-fungal properties, along with the capacity to modulate the immune system.
    3,5-Dimethyl-4-phenylisoxazole
  • HY-W844558
    Protein kinase inhibitor 11 721964-51-8 98.28%
    Protein kinase inhibitor 11 (Compound I-96) is a protein kinase inhibitor that can inhibit the activity of PIM-1, CDK-2, GSK-3, and SRC. Protein kinase inhibitor 11 holds promise for research in cancer, immune disorders, and neurodegenerative diseases.
    Protein kinase inhibitor 11
  • HY-W845197
    L-Asparagine-15N2 748757-99-5
    L-Asparagine-15N2 ((-)-Asparagine-15N2) is the 15N-labeled L-Asparagine (HY-N0667). L-Asparagine is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia.
    L-Asparagine-15N2
  • HY-W854443
    L-Fucose 87-96-7 98%
    L-Fucose (6-Deoxy-L-galactopyranose) is an orally active dietary sugar. L-Fucose is one of the key metabolites involved in the interaction between humans and the intestinal microbiota. L-Fucose binds to proteins as a post-translational modification through the fucosylation process, thereby regulating the behavior and function of proteins. L-Fucose has shown the ability to inhibit tumor growth and increase the infiltration of immune cells within tumors. L-Fucose can be used in cancer and anti-tumor immune research.
    L-Fucose
  • HY-W879508
    ALT-2074 173026-17-0 98%
    ALT-2074 (BXT-51071) is an orally active catalytic analogue of glutathione peroxidase. ALT-2074 is an inhibitor of human CYP3A, with its IC50 value ranging from 2.0 to 2.6 μM. ALT-2074 shows only a weak inhibitory effect on CYP3A in vivo, suggesting that it may not significantly affect the metabolism of CYP3A substrate drugs. ALT-2074 can be used to study inflammatory diseases characterized by reactive oxygen species, such as acute coronary syndrome.
    ALT-2074
  • HY-W900240
    BMS-978299 1610016-88-0
    BMS-978299 is an IRAK4 inhibitor that can be used for the study of immune disorders.
    BMS-978299
  • HY-W966480
    Oxindanac 68548-99-2
    Oxindanac is a nonsteroidal anti-inflammatory agent. Oxindanac produces inhibition of serum TxB2 production. Oxindanac reduces the volume of swelling. Oxindanac shows analgesic activity.
    Oxindanac
  • HY-W971442
    Moniliphenone 104022-80-2
    Moniliphenone (Compounds 5) is a secondary metabolite. Moniliphenone can be isolated from the endophytic fungus Penicillium chrysogenum. Moniliphenone has an anti-inflammatory activity and significantly inhibits TNF-α-stimulated NF-κB activation.
    Moniliphenone
  • HY-W982613
    SCA-40 142744-39-6 98%
    SCA-40 is a vasodilator for bronchial smooth muscle. SCA-40 produces biphasic relaxation on bronchi with spontaneous tension, and the relaxation effect is not inhibited by various potassium channel blockers. SCA-40 can be used for research on bronchial conditions.
    SCA-40
  • HY-W988549
    Zindotrine 56383-05-2
    Zindotrine (MDL-257) is an orally active bronchodilator. Zindotrine is a cGMP phosphodiesterase (PDE) inhibitor. Zindotrine can counteract bronchospasm caused by histamine. Zindotrine can be used to study reversible airflow obstruction, such as asthma.
    Zindotrine
  • HY-W989139
    Perforin-IN-3 178970-88-2
    Perforin-IN-3 is a specific perforin inhibitor that blocks perforin-mediated lytic pore formation and subsequent cell lysis. Perforin-IN-3 potently inhibits the killing effect of NK cells on target cells such as leukemia cells, without interfering with FasL- or TRAIL-mediated cell death pathways. Perforin-IN-3 has no effect on pneumolysin and can be used to study autoimmune diseases, allograft rejection, graft-versus-host disease, and familial hemophagocytic lymphohistiocytosis.
    Perforin-IN-3
  • HY-W995241
    BPD 213481-12-0 98%
    BPD is a COX-2 and TAK1-NF-κB inhibitor, with an IC50 of 18.5 μM for COX-2. BPD inhibits the expression of iNOS, TNF-α, IL-6 and IL-1β at the transcriptional level. BPD has anti-inflammatory activity. BPD can inhibit Carrageenan-induced paw oedema and LPS-induced septic death.
    BPD
  • HY-Z0548S1
    Methyl 3,4-dihydroxybenzoate-d3-1 2733147-54-9 98%
    Methyl 3,4-dihydroxybenzoate-d3-1 is the deuterium labeled Methyl 3,4-dihydroxybenzoate. Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester; Methyl protocatechuate) is a major metabolite of antioxidant polyphenols found in green tea. Antioxidant and anti-inflammatory effect.
    Methyl 3,4-dihydroxybenzoate-d3-1
Cat. No. Product Name / Synonyms Application Reactivity