2. Immunology/Inflammation
  3. Transmembrane Glycoprotein
  4. TJU103

TJU103 is a CD4 inhibitor. TJU103 inhibits autoreactive CD4+ T cells by disrupting the function of the CD4 during activation. TJU103 decreases mononuclear cell infiltration in brain and spinal cord tissue of experimental allergic encephalomyelitis (EAE) mice model. TJU103 downregulates Th1 and Th2 cytokine levels in response to proteolipid protein epitope 139-151 (PLPe) and exhibits inhibitory effects both after the appearance of EAE symptoms and upon rechallenge with Ag. TJU103 can be used for autoimmune diseases like EAE and sclerosis (MS) research.

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TJU103

TJU103 Chemical Structure

CAS No. : 10245-44-0

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TJU103 Related Antibodies

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Description

TJU103 is a CD4 inhibitor. TJU103 inhibits autoreactive CD4+ T cells by disrupting the function of the CD4 during activation. TJU103 decreases mononuclear cell infiltration in brain and spinal cord tissue of experimental allergic encephalomyelitis (EAE) mice model. TJU103 downregulates Th1 and Th2 cytokine levels in response to proteolipid protein epitope 139-151 (PLPe) and exhibits inhibitory effects both after the appearance of EAE symptoms and upon rechallenge with Ag. TJU103 can be used for autoimmune diseases like EAE and sclerosis (MS) research[1].

Cellular Effect
Cell Line Type Value Description References
HEL EC50
> 100 μg/mL
Compound: 8
Antiviral activity against Human herpesvirus 1 strain KOS infected in human HEL cells assessed as inhibition of virus-induced cytopathicity
Antiviral activity against Human herpesvirus 1 strain KOS infected in human HEL cells assessed as inhibition of virus-induced cytopathicity
10.1007/s00044-011-9662-9
HEL EC50
> 100 μg/mL
Compound: 8
Antiviral activity against Human herpesvirus 2 strain G infected human HEL cells assessed as inhibition of virus-induced cytopathicity
Antiviral activity against Human herpesvirus 2 strain G infected human HEL cells assessed as inhibition of virus-induced cytopathicity
10.1007/s00044-011-9662-9
HEL EC50
> 100 μg/mL
Compound: 8
Antiviral activity against TK(-) aciclovir-resistant Human herpesvirus 1 strain KOS infected in human HEL cells assessed as inhibition of virus-induced cytopathicity
Antiviral activity against TK(-) aciclovir-resistant Human herpesvirus 1 strain KOS infected in human HEL cells assessed as inhibition of virus-induced cytopathicity
10.1007/s00044-011-9662-9
HEL EC50
> 100 μg/mL
Compound: 8
Antiviral activity against Vaccinia virus infected human HEL cells assessed as inhibition of virus-induced cytopathicity
Antiviral activity against Vaccinia virus infected human HEL cells assessed as inhibition of virus-induced cytopathicity
10.1007/s00044-011-9662-9
HeLa EC50
> 100 μg/mL
Compound: 8
Antiviral activity against Human coxsackievirus B4 infected human HeLa cells assessed as inhibition of virus-induced cytopathicity
Antiviral activity against Human coxsackievirus B4 infected human HeLa cells assessed as inhibition of virus-induced cytopathicity
10.1007/s00044-011-9662-9
HeLa EC50
> 100 μg/mL
Compound: 8
Antiviral activity against Respiratory syncytial virus infected human HeLa cells assessed as inhibition of virus-induced cytopathicity
Antiviral activity against Respiratory syncytial virus infected human HeLa cells assessed as inhibition of virus-induced cytopathicity
10.1007/s00044-011-9662-9
HeLa EC50
> 100 μg/mL
Compound: 8
Antiviral activity against Vesicular stomatitis virus infected human HeLa cells assessed as inhibition of virus-induced cytopathicity
Antiviral activity against Vesicular stomatitis virus infected human HeLa cells assessed as inhibition of virus-induced cytopathicity
10.1007/s00044-011-9662-9
MT4 CC50
95 μg/mL
Compound: 8
Cytotoxicity against Homo sapiens (human) MT4 cells
Cytotoxicity against Homo sapiens (human) MT4 cells
10.1007/s00044-011-9662-9
MT4 EC50
> 95 μg/mL
Compound: 8
Antiviral activity against Human immunodeficiency virus 1 IIIB infected human MT4 cells assessed as inhibition of virus-induced cytopathicity
Antiviral activity against Human immunodeficiency virus 1 IIIB infected human MT4 cells assessed as inhibition of virus-induced cytopathicity
10.1007/s00044-011-9662-9
MT4 EC50
> 95 μg/mL
Compound: 8
Antiviral activity against Human immunodeficiency virus type 2 (ISOLATE ROD) infected human MT4 cells assessed as inhibition of virus-induced cytopathicity
Antiviral activity against Human immunodeficiency virus type 2 (ISOLATE ROD) infected human MT4 cells assessed as inhibition of virus-induced cytopathicity
10.1007/s00044-011-9662-9
Vero EC50
2.4 μg/mL
Compound: 8
Antiviral activity against Mammalian orthoreovirus 1 infected Vero cells assessed as inhibition of virus-induced cytopathicity
Antiviral activity against Mammalian orthoreovirus 1 infected Vero cells assessed as inhibition of virus-induced cytopathicity
10.1007/s00044-011-9662-9
Vero EC50
45 μg/mL
Compound: 8
Antiviral activity against Human coxsackievirus B4 infected Vero cells assessed as inhibition of virus-induced cytopathicity
Antiviral activity against Human coxsackievirus B4 infected Vero cells assessed as inhibition of virus-induced cytopathicity
10.1007/s00044-011-9662-9
Vero EC50
> 100 μg/mL
Compound: 8
Antiviral activity against Human parainfluenza virus 3 infected Vero cells assessed as inhibition of virus-induced cytopathicity
Antiviral activity against Human parainfluenza virus 3 infected Vero cells assessed as inhibition of virus-induced cytopathicity
10.1007/s00044-011-9662-9
Vero EC50
> 100 μg/mL
Compound: 8
Antiviral activity against Punta Toro virus infected Vero cells assessed as inhibition of virus-induced cytopathicity
Antiviral activity against Punta Toro virus infected Vero cells assessed as inhibition of virus-induced cytopathicity
10.1007/s00044-011-9662-9
Vero EC50
> 100 μg/mL
Compound: 8
Antiviral activity against Sindbis virus infected Vero cells assessed as inhibition of virus-induced cytopathicity
Antiviral activity against Sindbis virus infected Vero cells assessed as inhibition of virus-induced cytopathicity
10.1007/s00044-011-9662-9
Molecular Weight

264.28

Formula

C15H12N4O
CAS No.
SMILES

O=C(C1=CC=NC=C1)N/N=C/C2=CNC3=C2C=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TJU103 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TJU10310245-44-0TJU 103TJU-103Transmembrane GlycoproteinInhibitorCD4T cellsExperimental allergic encephalomyelitisEAE mice modelPLPeSclerosisMSinhibitorinhibit

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