2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W008440
    DL-Cycloserine 68-39-3 98%
    DL-Cycloserine is an orally active aminotransferase inhibitor. DL-Cycloserine exhibits completely opposite effects on the activity of monoamine oxidase in different tissues. DL-Cycloserine can be used for the research of pulmonary tuberculosis, psychosomatic diseases, and depressive states.
    DL-Cycloserine
  • HY-W009121
    Cbz-D-Trp-OH 2279-15-4 98.26%
    Cbz-D-Trp-OH is a competitive inhibitor of SCD, with IC50 of 86 μM and Ki of 71 μM.
    Cbz-D-Trp-OH
  • HY-W011214
    FABP4-IN-6 50257-40-4 98%
    FABP4-IN-6 is a FABP4 inhibitor with an IC50 of 16.8 μM. FABP4-IN-6 can be used in the research of diabetes and atherosclerosis.
    FABP4-IN-6
  • HY-W011340
    5-Hydroxy flunixin 75369-61-8 98%
    5-Hydroxy flunixin, the principal metabolite of Flunixin (HY-121046), retains the Flunixin's anti-inflammatory properties and plays a significant role in mitigating pain and inflammation in various veterinary applications. It assists in alleviating conditions such as colic in horses, musculoskeletal disorders, and infectious diseases in cattle, while also supporting the management of mastitis-metritis-agalactia syndrome in sows.
    5-Hydroxy flunixin
  • HY-W013007
    4-Hexen-3-one 2497-21-4 99.61%
    4-Hexen-3-one inhibits the growth of H. pylori strain ATCC 43526 and TDR H. pylori strains. 4-Hexen-3-one inhibits urease activities.
    4-Hexen-3-one
  • HY-W015338
    1-(4-Methoxyphenyl)-1-propanol 5349-60-0 98%
    1-(4-Methoxyphenyl)-1-propanol (Compound 2) is an orally active derivative of anethole. 1-(4-Methoxyphenyl)-1-propanol exhibits significant antioxidant activity. 1-(4-Methoxyphenyl)-1-propanol has anti-inflammatory activity and moderate gastric protective activity in mice. 1-(4-Methoxyphenyl)-1-propanol can be used for the study of gastric ulcers.
    1-(4-Methoxyphenyl)-1-propanol
  • HY-W016181
    Phenylhydroquinone 1079-21-6 99.21%
    Phenylhydroquinone (PHQ) is an orally active thymic atrophy inducer which can up-regulate apoptosis through activation of p53. PHQ can be used for research of thymic atrophy.
    Phenylhydroquinone
  • HY-W026426
    4,5,6,7-Tetrahydro-1,2-benzoxazole-3-carboxylic acid 90005-77-9 98.06%
    4,5,6,7-Tetrahydro-1,2-benzoxazole-3-carboxylic acid (Compound 244) is an indole compound. 4,5,6,7-Tetrahydro-1,2-benzoxazole-3-carboxylic acid does not inhibit COX-2 and shows the inhibition rate <1% against d-amino acid oxidase (DAO) at 10 μM.
    4,5,6,7-Tetrahydro-1,2-benzoxazole-3-carboxylic acid
  • HY-W071581
    Glucocorticoid receptor activator 1 14593-25-0 98%
    Glucocorticoid receptor activator 1 (compound A) is a phenyl aziridine precursor and an activator of the glucocorticoid receptor (GR). Glucocorticoid receptor activator 1 down-modulates TNF-induced pro-inflammatory gene expression by activating GR and can be utilized in inflammation research.
    Glucocorticoid receptor activator 1
  • HY-W073239
    (R)-2-Amino-5,5,5-trifluoropentanoic acid 122565-29-1
    (R)-2-Amino-5,5,5-trifluoropentanoic acid is a leucine antagonist. (R)-2-Amino-5,5,5-trifluoropentanoic acid increases Sestrin2 binding to GATOR2. (R)-2-Amino-5,5,5-trifluoropentanoic acid can be used in research on diabetes, neurodegenerative diseases, immune diseases, and cancer.
    (R)-2-Amino-5,5,5-trifluoropentanoic acid
  • HY-W074888
    N-Lauroyl-L-glutamic acid 3397-65-7 99.43%
    N-Lauroyl-L-glutamic acid is an amino acid derivative with anti-asthmatic activity. N-Lauroyl-L-glutamic acid has been found to improve asthma symptoms in studies. The potential application of N-Lauroyl-L-glutamic acid is mainly focused on the suppression of respiratory diseases. N-Lauroyl-L-glutamic acid may help improve the quality of life of patients.
    N-Lauroyl-L-glutamic acid
  • HY-W094745
    5,10,15,20-Tetrakis(4-chlorophenyl)porphyrin 22112-77-2 98%
    5,10,15,20-Tetrakis(4-chlorophenyl)porphyrin (Compound 5) is a photosensitizer. 5,10,15,20-Tetrakis(4-chlorophenyl)porphyrin shows no significant photodynamic cytotoxicity. 5,10,15,20-Tetrakis(4-chlorophenyl)porphyrin is mainly used for the optimization of photosensitizer structure in photodynamic therapy (PDT) for psoriasis.
    5,10,15,20-Tetrakis(4-chlorophenyl)porphyrin
  • HY-W095499
    Corydaldine 493-49-2 98.20%
    Corydaldine is a alkaloid. Corydaldine inhibits the production of NO in the BV2 cell line when stimulated by LPS.[1]
    Corydaldine
  • HY-W102335
    (Rac)-Threonine 7004-04-8 98%
    (Rac)-Threonine (Compound 19) is an amino acid derivative that can be found in the methanol (MeOH) extract of Rumex roseus L. The MeOH extract containing (Rac)-Threonine exhibits antioxidant and cytotoxic properties.
    (Rac)-Threonine
  • HY-W104752
    5-(Pyridin-4-yl)-1,3,4-oxadiazole-2-thiol 15264-63-8 99.34%
    5-(Pyridin-4-yl)-1,3,4-oxadiazole-2-thiol (Compound 3n) is an antimicrobial and antioxidant agent, that inhibits Escherichia coli and Staphylococcus epidermidis, with MIC of 8 and 4 μg/mL. 5-(Pyridin-4-yl)-1,3,4-oxadiazole-2-thiol exhibits antioxidant activity with IC50 of 17.47 μM using DPPH free radical-scavenging method.
    5-(Pyridin-4-yl)-1,3,4-oxadiazole-2-thiol
  • HY-W109401
    SIRT-IN-6 1431411-18-5 98%
    SIRT-IN-6 (Compound 14) is a pan-inhibitor of SIRT1/2/3 with IC50 values of >50 μM. SIRT-IN-6 is promising for research of metabolic, inflammatory, oncologic and neurodegenerative disorders.
    SIRT-IN-6
  • HY-W110154
    2'-Hydroxy-3,4-dimethoxychalcone 19152-36-4 98.01%
    2'-Hydroxy-3,4-dimethoxychalcone is a chalcone derivative and lipoxygenase inhibitor with an IC50 of 67.5 μM. 2'-Hydroxy-3,4-dimethoxychalcone acts as a radical scavenger that scavenges DPPH stable free radical, superoxide anion radical, and hydroxyl radical. 2'-Hydroxy-3,4-dimethoxychalcone scavenges hydrogen peroxide and inhibits linoleic acid lipid peroxidation. 2'-Hydroxy-3,4-dimethoxychalcone can be used for research on oxidative damage and inflammatory diseases.
    2'-Hydroxy-3,4-dimethoxychalcone
  • HY-W130878
    4-Octylphenol 1806-26-4 98%
    4-Octylphenol is a hormone disruptor that has gender-specific effects on male reproductive cells, significantly reducing the mitotic index and the number of spermatogonia. 4-Octylphenol can cause inflammatory damage to fish gills by activating the complement system through the C3a/C3aR axis and the C5a/C5aR1 axis, this leads to complement activation and causes immune suppression due to the imbalance between Th1/Th2 cells and regulatory T cells (Treg)/Th17 cells, as well as inflammatory damage via the Toll-like receptor 7 (Toll-like Receptor (TLR))/IκBα/NF-κB pathway.
    4-Octylphenol
  • HY-W131311
    m-Chlorohippuric acid 57728-59-3 99.46%
    m-Chlorohippuric acid (3-Chlorohippuric acid) is a substituted hippurate and substrate for peptidylglycine α-hydroxylating monooxygenase (PHM). m-Chlorohippuric acid can be used in research on cancer, rheumatoid arthritis, depression, and pesticides.
    m-Chlorohippuric acid
  • HY-W142456
    (S)-1-Benzyl-5-carboxy-2-pyrrolidinone 7535-59-3 98%
    (S)-1-Benzyl-5-carboxy-2-pyrrolidinone (N-Benzyl-L-pyroglutamic acid) is an orally active H+/K+-ATPase inhibitor. (S)-1-Benzyl-5-carboxy-2-pyrrolidinone reduces free acidity and total acidity in gastric juice. (S)-1-Benzyl-5-carboxy-2-pyrrolidinone decreases ulcer formation in pylorus-ligated rats. (S)-1-Benzyl-5-carboxy-2-pyrrolidinone can be used for the research of peptic ulcers.
    (S)-1-Benzyl-5-carboxy-2-pyrrolidinone
Cat. No. Product Name / Synonyms Application Reactivity