1. MAPK/ERK Pathway
  2. MEK
    Raf

Ro 5126766 (Synonyms: CH5126766)

Cat. No.: HY-18652 Purity: >98.0%
Data Sheet SDS Handling Instructions

Ro 5126766 (CH5126766) is a potent and selective dual RAF/MEK inhibitor. For SK-MEL-28, SK-MEL-2, MIAPaCa-2, and SW480 cell lines, the IC50 is determined by WST-8 assay is 65, 28, 40, and 46 nM, respectively.

For research use only. We do not sell to patients.
Ro 5126766 Chemical Structure

Ro 5126766 Chemical Structure

CAS No. : 946128-88-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO $220 In-stock
5 mg $200 In-stock
10 mg $350 In-stock
50 mg $960 In-stock
100 mg $1200 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

Ro 5126766 (CH5126766) is a potent and selective dual RAF/MEK inhibitor. For SK-MEL-28, SK-MEL-2, MIAPaCa-2, and SW480 cell lines, the IC50 is determined by WST-8 assay is 65, 28, 40, and 46 nM, respectively. IC50 value: 65 nM (SK-MEL-28), 28 nM(SK-MEL-2), 40 nM (MIAPaCa-2), and 46 nM (SW480) Target: RAF/MEK in vitro: Ro 5126766 induced G1 cell cycle arrest in two melanoma cell lines with the BRAF V600E or NRAS mutation. In these cells, the G1 cell cycle arrest was accompanied by up-regulation of the cyclin-dependent kinase inhibitor p27 and down-regulation of cyclinD1. Ro 5126766 was more effective at reducing colony formation than a MEK inhibitor in NRAS- or KRAS-mutated cells. In the RAS-mutated cells, Ro 5126766 suppressed the MEK reactivation caused by a MEK inhibitor. [1] in vivo: Ro 5126766 suppressed the tumor growth without body weight loss more than 10% in mice. In addition, Ro 5126766 suppressed the tumor growth in SK-MEL-2 xenograft model.[1]

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References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.1211 mL 10.6054 mL 21.2107 mL
5 mM 0.4242 mL 2.1211 mL 4.2421 mL
10 mM 0.2121 mL 1.0605 mL 2.1211 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

471.46

Formula

C₂₁H₁₈FN₅O₅S

CAS No.

946128-88-7

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Ro 5126766
Cat. No.:
HY-18652
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