1. Alkaloid
  2. Senecionine

Senecionine (Synonyms: Senecionan-11,16-dione, 12-hydroxy-; Aureine; Senecionin)

Cat. No.: HY-N2560
Handling Instructions

Senecionine is a pyrrolizidine alkaloid isolated from Senecio vulgaris. Senecionine is toxic to animals and humans.

For research use only. We do not sell to patients.

Senecionine Chemical Structure

Senecionine Chemical Structure

CAS No. : 130-01-8

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Description

Senecionine is a pyrrolizidine alkaloid isolated from Senecio vulgaris. Senecionine is toxic to animals and humans.

In Vitro

Pyrrolizidine alkaloids (PAs) are considered to be one of the most hepatotoxic groups of compounds of plant origin and are present in about 3% of the world's flowering plants. Most PAs represent a considerable health hazard to both livestock and humans through the consumption of plants and PA-contaminated products such as milk, honey, herbal teas, and medicines[1].

In Vivo

Upon intravenous administration and oral administration of Senecionine and Adonifoline, significant differences in pharmacokinetics were observed, with the Senecionine and Adonifoline being absorbed fast with lower bioavailability and being quickly metabolized to PA N-oxides and hydroxylation products of PAs or their N-oxides[1]. Senecionine fails to stimulate epoxide hydrase, it diminishs the activity of glutathione-s-transferase, aminopyrine demethylase and AHH[2]. Twice-weekly injections of a third constituent, senecionine, beginning on Day 12 or later, results in premature deliveries in three of seven rats, and the pups from all litters are stillborn or die shortly after birth[3].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Animal Administration
[1]

Rats[1]

Swiss albino rats weighing 155-175 g are incubated for 3 consecutive days with seneciphylline and senecionine at a daily dose of 40 or 80 mg/kg body wt. Control animals received normal saline only. The animals are killed 24 h after the last dose. The livers are removed, weighed and then homogenized in 1.15% KCI, 0.02 HEPES (pH 7.4)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

335.39

Formula

C₁₈H₂₅NO₅

CAS No.

130-01-8

SMILES

O=C1O[[email protected]@]2([H])[[email protected]]3([H])N(CC=C3COC([[email protected]](C)(O)[[email protected]](C)C/C1=C/C)=O)CC2

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Senecionine
Cat. No.:
HY-N2560
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Senecionine

Cat. No.: HY-N2560