Cholinesterase (ChE)
Cholinesterase (ChE) is a family of enzymes present in the central nervous system, particularly in nervous tissue, muscle and red cells, which catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation. It is one of many important enzymes needed for the proper functioning of the nervous systems of humans.
There are two types: acetylcholinesterase (AChE, acetylcholine hydrolase) and butyrylcholinesterase (BChE, acylcholine acylhydrolase), also known as nonspecific cholinesterase or pseudocholinesterase. AChE is primarily found in the blood on red blood cell membranes, in neuromuscular junctions, and in neural synapses, while BChE is produced in the liver and found primarily in plasma. The difference between the two types of cholinesterase is their relative preferences for substrates: AChE hydrolyzes acetylcholine faster while BChE hydrolyzes butyrylcholine faster.
Cholinesterase (ChE) Isoform Specific Products
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Cholinesterase (ChE) Related Products (1058)
Related Products (1058)
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Antibodies (2)
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Cholinesterase (ChE) Isoform Comparison
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Carbaryl-d3
0 ImagesCat. No.: HY-B1315SCAS No.: 1433961-56-8
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Dimethyl sulfoxide-13C2
0 ImagesCat. No.: HY-W782446CAS No.: 136321-15-8Synonyms: DMSO-13C2Dimethyl sulfoxide-13C2 (DMSO-13C2) is the 13C-labeled Dimethyl sulfoxide (HY-Y0320C). Dimethyl sulfoxide (DMSO) is an aprotic solvent that can dissolve water-insoluble therapeutic and toxic agents. Dimethyl sulfoxide (DMSO) has a strong affinity for water and has the ability to rapidly penetrate or enhance the penetration of?other?substances through biological membranes. Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity. Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity.
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PJ17
0 ImagesCat. No.: HY-181811CAS No.: 2248983-31-3PJ17 is a potent dual-target inhibitor of AChE and GSK-3β, with IC50 values of 8.84 μM and 4.19 μM, respectively. PJ17 shows no significant neurotoxic effect in primary cerebellar granule neuron cultures. PJ17 serves as a template for the design of multitarget drugs. PJ17 can be used for the research of Alzheimer's disease.
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AChE-IN-43
0 ImagesCat. No.: HY-156358AChE-IN-43 is a potent and selective inhibitor of AChE with a Ki of 0.41 μM. AChE-IN-43 can be used in study neurological disease.
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BChE-IN-50
0 ImagesCat. No.: HY-184658CAS No.: 3132777-83-1BChE-IN-50 is an orally active human butyrylcholinesterase (hBChE) inhibitor with an IC50 of 0.28 μM and a Ki of 0.78 μM. As a ROS inhibitor, BChE-IN-50 protects nerve cells from toxic damage induced by hydrogen peroxide and Aβ1-42, and alleviates Aβ-induced cognitive impairment in mice. BChE-IN-50 can be used for the research of Alzheimer's disease.
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Magnotriol B
0 ImagesCat. No.: HY-N15710CAS No.: 92829-71-5Magnotriol B is a cholinesterase inhibitor with IC50 values of 12.63 nM and 14.5 nM against AChE and BChE, respectively. Magnotriol B also exhibits significant NO inhibitory activity with an IC50 of 2.02 μM. Magnotriol B can be used in the research of neurodegenerative and inflammatory diseases.
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BChE-IN-33
0 ImagesCat. No.: HY-159143BChE-IN-33 (compound 4r), an arylaminonaphthol derivative, is a potent butyrylcholinesterase (BChE) inhibitor with an IC50 of 14.78 µM. BChE-IN-33 also inhibits CYP2C19, CYP2C9, CYP2D6. BChE-IN-33 shows potent antioxidant activity with IC50 values of 150.48 μM, 2.56 μM and 4.61 μM by DPPH, ABTS, Ferric-phenanthroline assay, respectively. BChE-IN-33 has the potential for Alzheimer research.
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AChE-IN-75
0 ImagesCat. No.: HY-162915AChE-IN-75 (N-(2′-methyl)allylnorgalanthamine) is an AChE inhibitor. AChE-IN-75 can be used in Alzheimer's disease research.
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Uridine 5'-monophosphate disodium salt (Standard)
0 ImagesSynonyms: 5'-Uridylic acid disodium salt (Standard)Uridine 5'-monophosphate (disodium salt) (Standard) is the analytical standard of Uridine 5'-monophosphate (disodium salt). This product is intended for research and analytical applications. Uridine 5'-monophosphate (5'-Uridylic acid) disodium salt is an orally active mitochondrial ATP-dependent potassium channel activator that has a protective effect on the heart. Uridine 5'-monophosphate disodium salt can promote the synthesis of CDP-choline and induce apoptosis in intestinal epithelial cells, which is beneficial for gut development and reduces diarrhea.
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Picfeltarraegenin X
0 ImagesCat. No.: HY-N2219CAS No.: 1391826-61-1Picfeltarraenin X, a triterpenoid isolated, is an AChE inhibitor.
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Picfeltarraenin IA (Standard)
0 ImagesCat. No.: HY-N1474RCAS No.: 97230-47-2Picfeltarraenin IA (Standard) is the analytical standard of Picfeltarraenin IA (HY-N1474). This product is intended for research and analytical applications. Picfeltarraenin IA is an Acetylcholinesterase inhibitor. Picfeltarraenin IA can be extracted from the plant Picria fel-terrae Lour. Picfeltarraenin IA reduces the production of IL-8 and PGE2. Picfeltarraenin IA inhibits COX2 via the NF-κB pathway. Picfeltarraenin IA can be used in the research of respiratory system diseases.
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Imperatorin-d6
0 ImagesCat. No.: HY-N0285SSynonyms: Ammidin-d6Imperatorin-d6 (Ammidin-d6) is the deuterium labeled Imperatorin. Imperatorin is a BChE inhibitor and HIV-1 replication inhibitor. Imperatorin shows mild activity against Gram-negative bacteria.
